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anti-hsp60 antibody :: Rabbit anti-Human hsp60 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS852215
Unit / Price
0.1 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

hsp60, Polyclonal Antibody

★Popular Item★
 Also Known As   

hsp60 Antibody

 Product Gene Name   

anti-hsp60 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612233
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Form/Format    Lyophilized anti-hsp60 antibody purified by peptide affinity column containing 2% BSA and 0.02% NaN3
 Concentration    100ug/200ul (lot specific)
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 Source Note    Rabbit polyclonal hsp60 (1) antibody was raised against a peptide near the intermediate residues of human hsp60 protein.
 Reactivity Note    Not yet tested in other species.
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 Preparation and Storage    Already reconstituted in 200ul sterile H2O. The antibody is stable for at least one year when stored at -20 degree C after reconstitution. Avoid repeated freeze/defrost cycles.
 Other Notes    Small volumes of anti-hsp60 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-hsp60 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-hsp60 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-hsp60 antibody    Peptide ELISA titer: 1:40,000-1:80,000
Western blot analysis: 1:200-1,000
Immunohistochemistry: 1:50-200
Optimal dilutions/concentrations should be determined by the end user.
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 Testing Data of anti-hsp60 antibody    anti-hsp60 antibody Testing Data image
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 Testing Data #2 of anti-hsp60 antibody    anti-hsp60 antibody Testing Data #2 image
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NCBI/Uniprot data below describe general gene information for hsp60. It may not necessarily be applicable to this product.
 NCBI GI #    41399283
 NCBI GeneID    3329
 NCBI Accession #    NP_002147.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002156 [Other Products]
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 UniProt Secondary Accession #    Q38L19; Q9UCR6; B2R5M6; B7Z712 [Other Products]
 UniProt Related Accession #    P10809 [Other Products]
 Molecular Weight    17,100 Da
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 NCBI Official Full Name    Homo sapiens heat shock 60kDa protein 1 (chaperonin) (HSPD1), transcript variant 1, mRNA
 NCBI Official Synonym Full Names    heat shock 60kDa protein 1 (chaperonin)
 NCBI Official Symbol    HSPD1 [Similar Products]
 NCBI Official Synonym Symbols   
HLD4; CPN60; GROEL; HSP60; HSP65; SPG13; HSP-60; HuCHA60
[Similar Products]
 NCBI Protein Information    60 kDa heat shock protein, mitochondrial; chaperonin 60; 60 kDa chaperonin; heat shock protein 65; P60 lymphocyte protein; mitochondrial matrix protein P1; short heat shock protein 60 Hsp60s1
 UniProt Protein Name    60 kDa heat shock protein, mitochondrial
 UniProt Synonym Protein Names   
60 kDa chaperonin; Chaperonin 60; CPN60; Heat shock protein 60; HSP-60; Hsp60; HuCHA60; Mitochondrial matrix protein P1; P60 lymphocyte protein
 Protein Family    Hydrogenosomal chaperonin
 UniProt Gene Name    HSPD1 [Similar Products]
 UniProt Synonym Gene Names    HSP60; CPN60; HSP-60; Hsp60 [Similar Products]
 UniProt Entry Name    CH60_HUMAN
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 NCBI Summary for hsp60    This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13. [provided by RefSeq, Jun 2010]
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 UniProt Comments for hsp60    HSP60: Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. Interacts with HRAS. Interacts with HBV protein X and HTLV-1 protein p40tax. Belongs to the chaperonin (HSP60) family.

Protein type: Mitochondrial; Chaperone

Chromosomal Location of Human Ortholog: 2q33.1

Cellular Component: extracellular space; protein complex; cell surface; mitochondrion; early endosome; coated pit; cytosol; secretory granule; membrane; mitochondrial matrix; mitochondrial inner membrane; cytoplasm; plasma membrane; lipopolysaccharide receptor complex; cyclin-dependent protein kinase activating kinase holoenzyme complex

Molecular Function: protein binding; p53 binding; lipopolysaccharide binding; chaperone binding; ubiquitin protein ligase binding; double-stranded RNA binding; ATPase activity; unfolded protein binding; DNA replication origin binding; ATP binding; single-stranded DNA binding

Biological Process: B cell proliferation; caspase activation; viral reproduction; T cell activation; protein stabilization; B cell activation; positive regulation of apoptosis; positive regulation of interleukin-12 production; protein maturation; isotype switching to IgG isotypes; positive regulation of interleukin-6 production; B cell cytokine production; response to unfolded protein; positive regulation of interleukin-10 production; MyD88-dependent toll-like receptor signaling pathway; positive regulation of interferon-gamma production; 'de novo' protein folding; protein refolding; positive regulation of T cell activation; positive regulation of T cell mediated immune response to tumor cell; chaperone-mediated protein complex assembly; positive regulation of interferon-alpha production; negative regulation of apoptosis; positive regulation of macrophage activation

Disease: Spastic Paraplegia 13, Autosomal Dominant; Leukodystrophy, Hypomyelinating, 4
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 Research Articles on hsp60    1. Data suggest that up-regulation of HSP60/HSPD1 binding/reactivity leads to increased cytokine synthesis/secretion and other proinflammatory responses in adipocytes, especially in mature visceral adipocytes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-hsp60 antibodyPathways associated with anti-hsp60 antibody
 Reference Product  PubMed Publications
 HSPE1 antibody  >8 publications with hsp60 and HSPE1
 TLR4 antibody  >4 publications with hsp60 and TLR4
 CASP3 antibody  >4 publications with hsp60 and CASP3
 TLR2 antibody  >3 publications with hsp60 and TLR2
 Products by Pathway  Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Mitochondrial Protein Import Pathway antibodies  Mitochondrial Protein Import Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 RNA Degradation Pathway antibodies  RNA Degradation Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Type I Diabetes Mellitus Pathway antibodies  Type I Diabetes Mellitus Pathway Diagram
Diseases associated with anti-hsp60 antibodyOrgans/Tissues associated with anti-hsp60 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >17 publications with hsp60 and Cardiovascular Diseases
 Inflammation Antibodies  >13 publications with hsp60 and Inflammation
 Disease Models, Animal Antibodies  >12 publications with hsp60 and Disease Models, Animal
 Carcinoma Antibodies  >11 publications with hsp60 and Carcinoma
 Brain Diseases Antibodies  >11 publications with hsp60 and Brain Diseases
 Heart Diseases Antibodies  >8 publications with hsp60 and Heart Diseases
 Atherosclerosis Antibodies  >7 publications with hsp60 and Atherosclerosis
 Necrosis Antibodies  >6 publications with hsp60 and Necrosis
 Hyperplasia Antibodies  >5 publications with hsp60 and Hyperplasia
 Lung Diseases Antibodies  >5 publications with hsp60 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >26 publications with hsp60 and Blood
 Brain Antibodies  >12 publications with hsp60 and Brain
 Muscle Antibodies  >10 publications with hsp60 and Muscle
 Heart Antibodies  >8 publications with hsp60 and Heart
 Liver Antibodies  >7 publications with hsp60 and Liver
 Kidney Antibodies  >6 publications with hsp60 and Kidney
 Vascular Antibodies  >5 publications with hsp60 and Vascular
 Lung Antibodies  >4 publications with hsp60 and Lung
 Bone Antibodies  >4 publications with hsp60 and Bone
 Intestine Antibodies  >4 publications with hsp60 and Intestine
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