AAH08185.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Hydroxysteroid (17-beta) dehydrogenase 8
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 8
NCBI Official Synonym Symbols
KE6; FABG; HKE6; FABGL; RING2; H2-KE6; SDR30C1; D6S2245E; dJ1033B10.9 [Similar Products]
NCBI Protein Information
estradiol 17-beta-dehydrogenase 8; ke-6; protein Ke6; 17-beta-HSD 8; estrogen 17-oxidoreductase; testosterone 17-beta-dehydrogenase 8; really interesting new gene 2 protein; 17-beta-hydroxysteroid dehydrogenase 8; 3-oxoacyl-[acyl-carrier-protein] reductase; short chain dehydrogenase/reductase family 30C, member 1
UniProt Protein Name
Estradiol 17-beta-dehydrogenase 8
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 8; 17-beta-HSD 8; 3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-); Protein Ke6; Ke-6; Really interesting new gene 2 protein; Testosterone 17-beta-dehydrogenase 8 (EC:1.1.1.239)
UniProt Synonym Gene Names
UniProt Entry Name
DHB8_HUMAN
NCBI Summary for HSD17B8
In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. The protein encoded by this gene is similar to Ke6 and is a member of the short-chain dehydrogenase superfamily. An alternatively spliced transcript of this gene has been detected, but the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
UniProt Comments for HSD17B8
HSD17B8: NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heteroteramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Mitochondrial; EC 1.1.1.62; EC 1.1.1.239; Lipid Metabolism - androgen and estrogen; Oxidoreductase
Chromosomal Location of Human Ortholog: 6p21.3
Cellular Component: mitochondrial envelope; mitochondrial matrix; plasma membrane
Molecular Function: estradiol 17-beta-dehydrogenase activity; protein binding; 3-hydroxyacyl-CoA dehydrogenase activity; 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
Biological Process: androgen metabolic process; estrogen biosynthetic process; fatty acid biosynthetic process
Research Articles on HSD17B8
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Pathways associated with anti-HSD17B8 antibody
Diseases associated with anti-HSD17B8 antibody
Organs/Tissues associated with anti-HSD17B8 antibody
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