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anti-NOS2 antibody :: Rabbit iNOS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175511
Testing Data
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

iNOS (NOS2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-iNOS antibody

 Product Synonym Names    Nitric oxide synthase, inducible; nitric oxide synthase 2, inducible; HEP NOS antibody; HEP-NOS antibody; Hepatocyte NOS antibody; HEPNOS antibody; inducible antibody; Inducible nitric oxide synthase antibody; Inducible NO synthase antibody; Inducible NOS antibody; INOS antibody; Inosl antibody; MAC NOS antibody; Macrophage NOS antibody; Nitric oxide synthase 2 inducible antibody; Nitric oxide synthase 2 inducible macrophage antibody; Nitric oxide synthase 2A(inducible hepatocytes) antibody; Nitric oxide synthase antibody; Nitric oxide synthase inducible antibody; NOS 2 antibody; NOS 2A antibody; NOS antibody; Nos II antibody; NOS type II antibody; Nos2 antibody; NOS2_HUMAN antibody; NOS2A antibody; Peptidyl-cysteine S-nitrosylase NOS2 antibody
 Product Gene Name   

anti-NOS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 611162
 3D Structure    ModBase 3D Structure for P35228
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the C-terminus of human iNOS (1110-1124aa VEDYFFQLKSQKRYH), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NOS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NOS2 antibody

   Description: Rabbit IgG polyclonal antibody for Nitric oxide synthase, inducible(NOS2) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: Nitric oxide synthase, inducible is an enzyme that in humans is encoded by the NOS2 gene. Nitric oxide(NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter; it is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. Three different NOS isoforms have been identified which fall into two distinct types, constitutive and inducible. The inducible NOS(iNOS) isoform is expressed in a variety of cell types and tissues in response to inflammatory agents and cytokines. The human iNOS(NOS2) gene is approximately 37 kb in length and consists of 26 exons and 25 introns. Diefenbach et al.(1999) studied the relationship of IL12 and nitric oxide synthase-2(NOS2) to innate immunity to the parasite Leishmania in mice. And conclude that NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity. From studies in Tanzania and Kenya, Hobbs et al.(2002) identified a novel single-nucleotide polymorphism, -1173C-T(163730.0001), in the NOS2 promoter that was significantly associated with protection from symptomatic malaria and severe malarial anemia.
 Applications Tested/Suitable for anti-NOS2 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Testing Data of anti-NOS2 antibody    anti-NOS2 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for NOS2. It may not necessarily be applicable to this product.
 NCBI GI #    1352513
 NCBI GeneID    4843
 NCBI Accession #    P35228.2 [Other Products]
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 UniProt Primary Accession #    P35228 [Other Products]
 UniProt Secondary Accession #    O60757; O94994; Q16263; Q16692; Q4TTS5; Q9UD42; A1L3U5; B7ZLY2 [Other Products]
 UniProt Related Accession #    P35228 [Other Products]
 Molecular Weight    126,749 Da
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 NCBI Official Full Name    Nitric oxide synthase, inducible
 NCBI Official Synonym Full Names    nitric oxide synthase 2, inducible
 NCBI Official Symbol    NOS2 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; INOS; NOS2A; HEP-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, inducible; NOS type II; NOS, type II; inducible NOS; hepatocyte NOS; inducible NO synthase; nitric oxide synthase, macrophage; peptidyl-cysteine S-nitrosylase NOS2; nitric oxide synthase 2A (inducible, hepatocytes)
 UniProt Protein Name    Nitric oxide synthase, inducible
 UniProt Synonym Protein Names   
Hepatocyte NOS; HEP-NOS; Inducible NO synthase; Inducible NOS; iNOS; NOS type II; Peptidyl-cysteine S-nitrosylase NOS2
 Protein Family    Inositol 3-kinase
 UniProt Gene Name    NOS2 [Similar Products]
 UniProt Synonym Gene Names    NOS2A; HEP-NOS; Inducible NOS; iNOS [Similar Products]
 UniProt Entry Name    NOS2_HUMAN
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 NCBI Summary for NOS2    Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
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 UniProt Comments for NOS2    iNOS: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2. Homodimer. Binds SLC9A3R1. By endotoxins and cytokines. Induced by IFNG/IFN-gamma acting synergistically with bacterial lipopolysaccharides (LPS), TNF or IL1B/interleukin-1 beta. Expressed in the liver, retina, bone cells and airway epithelial cells of the lung. Not expressed in the platelets. Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity. Belongs to the NOS family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.13.39; Oxidoreductase; Amino Acid Metabolism - arginine and proline

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cortical cytoskeleton; perinuclear region of cytoplasm; cytoplasm; peroxisome; intracellular; cytosol; nucleus

Molecular Function: calmodulin binding; protein binding; protein homodimerization activity; FAD binding; FMN binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; iron ion binding; heme binding; NADP binding; receptor binding

Biological Process: circadian rhythm; interaction with host; superoxide metabolic process; positive regulation of guanylate cyclase activity; positive regulation of killing of cells of another organism; positive regulation of vasodilation; defense response to Gram-negative bacterium; regulation of cell proliferation; regulation of cellular respiration; positive regulation of leukocyte mediated cytotoxicity; innate immune response in mucosa; response to bacterium; defense response to bacterium; response to hypoxia; peptidyl-cysteine S-nitrosylation; arginine catabolic process; negative regulation of blood pressure; nitric oxide biosynthetic process; blood coagulation; negative regulation of protein catabolic process; inflammatory response; nitric oxide mediated signal transduction; regulation of insulin secretion

Disease: Hypertension, Essential; Malaria, Susceptibility To
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 Research Articles on NOS2    1. Our findings suggest that a significant combined effect of NQO1 C/T and T/T genotypes and the 12-repeat allele of iNOS (CCTTT)n polymorphism on bladder cancer exists, especially in those with the habit of cigarette smoking.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-NOS2 antibodyDiseases associated with anti-NOS2 antibody
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2483 publications with NOS2 and Inflammation
 Necrosis Antibodies  >2030 publications with NOS2 and Necrosis
 Sepsis Antibodies  >571 publications with NOS2 and Sepsis
 Intestinal Diseases Antibodies  >412 publications with NOS2 and Intestinal Diseases
 Liver Diseases Antibodies  >379 publications with NOS2 and Liver Diseases
 Reperfusion Injury Antibodies  >378 publications with NOS2 and Reperfusion Injury
 Hypertension Antibodies  >299 publications with NOS2 and Hypertension
 Endotoxemia Antibodies  >259 publications with NOS2 and Endotoxemia
 Shock, Septic Antibodies  >249 publications with NOS2 and Shock, Septic
 Kidney Diseases Antibodies  >225 publications with NOS2 and Kidney Diseases
Organs/Tissues associated with anti-NOS2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2687 publications with NOS2 and Blood
 Brain Antibodies  >1121 publications with NOS2 and Brain
 Lung Antibodies  >862 publications with NOS2 and Lung
 Intestine Antibodies  >500 publications with NOS2 and Intestine
 Pancreas Antibodies  >223 publications with NOS2 and Pancreas
 Stomach Antibodies  >217 publications with NOS2 and Stomach
 Connective Tissue Antibodies  >98 publications with NOS2 and Connective Tissue
 Embryonic Tissue Antibodies  >90 publications with NOS2 and Embryonic Tissue
 Mixed Antibodies  >73 publications with NOS2 and Mixed
 Ovary Antibodies  >48 publications with NOS2 and Ovary
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