Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow IDUA rightarrow Polyclonal IDUA  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Arachidonic Acid (AA) ELISA Kit
 • S100 Calcium Binding Protein A9 (S100A9) ELISA Kit
 • C-type lectin domain family 7 member A (Clec7a) Recombinant Protein
 • MRE11 meiotic recombination 11 homolog A (S. cerevisiae) (M... ELISA Kit
 • Complement Factor P (CFP) ELISA Kit
 • CX26 ELISA Kit
 • Interleukin 21 (IL21) ELISA Kit
 • Terminal Complement Complex C5b-9 (TCC C5b-9) ELISA Kit
 • ZNF19 Antibody
 • Gamma Aminobutyric Acid (GABA) ELISA Kit
 • Tryptophan Hydroxylase (TPH1) Antibody
 • Heat Shock Protein 70 (HSP70) ELISA Kit
 • T-box 3 (TBX3) Antibody
 • CD71 Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-IDUA antibody :: Rabbit iduronidase, alpha-L- Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710652 anti-IDUA antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

iduronidase, alpha-L- (IDUA), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human iduronidase, alpha-L- polyclonal Antibody

 Product Synonym Names    iduronidase; alpha-L-; IDUA; IDA; MPS1
 Product Gene Name   

anti-IDUA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 MBS710652 Technical Datasheet    Technical Datasheet PDF
 OMIM    607016
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Immunogen    Human IDUA
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-241187 / sc-241189
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IDUA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-IDUA antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for IDUA. It may not necessarily be applicable to this product.
 NCBI GI #    119603033
 NCBI GeneID    3425
 NCBI Accession #    EAW82627.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    B3KWK6 [Other Products]
 UniProt Related Accession #    P35475 [Other Products]
 Molecular Weight    73,455 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    iduronidase, alpha-L-, isoform CRA_j
 NCBI Official Synonym Full Names    iduronidase, alpha-L-
 NCBI Official Symbol    IDUA [Similar Products]
 NCBI Official Synonym Symbols   
IDA; MPS1
[Similar Products]
 NCBI Protein Information    alpha-L-iduronidase
 UniProt Protein Name    Alpha-L-iduronidase
 Protein Family    Alpha-L-iduronidase
 UniProt Gene Name    IDUA [Similar Products]
 UniProt Entry Name    IDUA_HUMAN
Section Bar
 NCBI Summary for IDUA    This gene encodes an enzyme that hydrolyzes the terminal alpha-L-iduronic acid residues of two glycosaminoglycans, dermatan sulfate and heparan sulfate. This hydrolysis is required for the lysosomal degradation of these glycosaminoglycans. Mutations in this gene that result in enzymatic deficiency lead to the autosomal recessive disease mucopolysaccharidosis type I (MPS I). [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for IDUA    IDUA: Defects in IDUA are the cause of mucopolysaccharidosis type 1H (MPS1H); also known as Hurler syndrome. MPS1H is a severe form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1H usually present, within the first year of life, a combination of hepatosplenomegaly, skeletal deformities, corneal clouding and severe mental retardation. Obstructive airways disease, respiratory infection and cardiac complications usually result in death before 10 years of age. Defects in IDUA are the cause of mucopolysaccharidosis type 1H/S (MPS1H/S); also known as Hurler-Scheie syndrome. MPS1H/S is a form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. MPS1H/S represents an intermediate phenotype of the MPS1 clinical spectrum. It is characterized by relatively little neurological involvement, but most of the somatic symptoms described for severe MPS1 develop in the early to mid-teens, causing considerable loss of mobility. Defects in IDUA are the cause of mucopolysaccharidosis type 1S (MPS1S); also known as Scheie syndrome. MPS1S is a mild form of mucopolysaccharidosis type 1, a rare lysosomal storage disease characterized by progressive physical deterioration with urinary excretion of dermatan sulfate and heparan sulfate. Patients with MPS1S may have little or no neurological involvement, normal stature and life span, but present development of joints stiffness, mild hepatosplenomegaly, aortic valve disease and corneal clouding. Belongs to the glycosyl hydrolase 39 family.

Protein type: Glycan Metabolism - glycosaminoglycan degradation; EC 3.2.1.76; Hydrolase

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: lysosomal lumen

Molecular Function: L-iduronidase activity; receptor binding

Biological Process: glycosaminoglycan metabolic process; disaccharide metabolic process; dermatan sulfate catabolic process; cell morphogenesis; pathogenesis; limb morphogenesis; chemical homeostasis; chondroitin sulfate metabolic process; glycosaminoglycan catabolic process; lysosome organization and biogenesis; skeletal morphogenesis; chondroitin sulfate catabolic process; carbohydrate metabolic process

Disease: Hurler-scheie Syndrome; Scheie Syndrome; Hurler Syndrome
Table BarTOPTable Bar
 Research Articles on IDUA    1. Amino acid substitutions in alpha-L-iduronidase determine the severity of mucopolysaccharidosis type I.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-IDUA antibodyPathways associated with anti-IDUA antibody
 Reference Product  PubMed Publications
 IDS antibody  >6 publications with IDUA and IDS
 SGSH antibody  >3 publications with IDUA and SGSH
 ARSB antibody  >3 publications with IDUA and ARSB
 Products by Pathway  Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Dermatan Sulfate Degradation Pathway antibodies  Dermatan Sulfate Degradation Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycogen Storage Diseases Pathway antibodies  Glycogen Storage Diseases Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Degradation Pathway antibodies  Glycosaminoglycan Degradation Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 HS-GAG Degradation Pathway antibodies  HS-GAG Degradation Pathway Diagram
Diseases associated with anti-IDUA antibodyOrgans/Tissues associated with anti-IDUA antibody
 Disease Name  Pubmed Publications
 Mucopolysaccharidosis I Antibodies  >136 publications with IDUA and Mucopolysaccharidosis I
 Nervous System Diseases Antibodies  >19 publications with IDUA and Nervous System Diseases
 Brain Diseases Antibodies  >17 publications with IDUA and Brain Diseases
 Heart Diseases Antibodies  >10 publications with IDUA and Heart Diseases
 Movement Disorders Antibodies  >6 publications with IDUA and Movement Disorders
 Aortic Diseases Antibodies  >5 publications with IDUA and Aortic Diseases
 Inflammation Antibodies  >4 publications with IDUA and Inflammation
 Musculoskeletal Diseases Antibodies  >4 publications with IDUA and Musculoskeletal Diseases
 IMMUNE SUPPRESSION Antibodies  >4 publications with IDUA and IMMUNE SUPPRESSION
 Lung Diseases Antibodies  >3 publications with IDUA and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >57 publications with IDUA and Blood
 Brain Antibodies  >45 publications with IDUA and Brain
 Bone Antibodies  >31 publications with IDUA and Bone
 Heart Antibodies  >22 publications with IDUA and Heart
 Kidney Antibodies  >11 publications with IDUA and Kidney
 Skin Antibodies  >9 publications with IDUA and Skin
 Lung Antibodies  >9 publications with IDUA and Lung
 Ovary Antibodies  >7 publications with IDUA and Ovary
 Eye Antibodies  >6 publications with IDUA and Eye
 Uterus Antibodies  >4 publications with IDUA and Uterus
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions