Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow ITPR1 rightarrow Polyclonal ITPR1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Poly ADP Ribose Polymerase (PARP) ELISA Kit
 • RANK:Fc Recombinant Protein
 • SIRT3 Antibody
 • Large envelope protein (S) Recombinant Protein
 • PREALBUMIN (TTR) Antibody
 • OAS1 Recombinant Protein
 • Semaphorin 5B (SEMA5B) Antibody
 • PLCG2 Antibody
 • Hyaluronidase-2 (HYAL2) Antibody
 • Adiponectin (ADIPOQ) Antibody
 • MEF2C Antibody
 • Laminin Alpha 1 (LAMa1) Recombinant Protein
 • Erythropoietin-alpha (EPO) Recombinant Protein
 • albumin Native Protein
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-ITPR1 antibody :: Rabbit inositol 1, 4, 5-triphosphate receptor, type 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716770 anti-ITPR1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

inositol 1, 4, 5-triphosphate receptor, type 1 (ITPR1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human inositol 1, 4, 5-triphosphate receptor, type 1 polyclonal Antibody

 Product Synonym Names    inositol 1; 4; 5-triphosphate receptor; type 1; ITPR1; INSP3R1; IP3R; IP3R1; SCA15; SCA16
 Product Gene Name   

anti-ITPR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    gene 606658
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen Affinity Purified
Section Bar
 Immunogen    Human ITPR1-specific
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-26382 / sc-26381 / sc-6093 / sc-28614
Section Bar
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ITPR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-ITPR1 antibody   

ELISA (EIA), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for ITPR1. It may not necessarily be applicable to this product.
 NCBI GI #    269954694
 NCBI GeneID    3708
 NCBI Accession #    NP_001161744.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001168272.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    Q14660; Q99897; E7EPX7; E9PDE9 [Other Products]
 UniProt Related Accession #    Q14643 [Other Products]
 Molecular Weight    309,338 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    inositol 1,4,5-trisphosphate receptor type 1 isoform 3
 NCBI Official Synonym Full Names    inositol 1,4,5-trisphosphate receptor, type 1
 NCBI Official Symbol    ITPR1 [Similar Products]
 NCBI Official Synonym Symbols   
ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94
[Similar Products]
 NCBI Protein Information    inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; IP3 receptor; type 1 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 1; protein phosphatase 1, regulatory subunit 94; type 1 inositol 1,4,5-trisphosphate receptor
 UniProt Protein Name    Inositol 1,4,5-trisphosphate receptor type 1
 UniProt Synonym Protein Names   
IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
 Protein Family    Inositol 1,4,5-trisphosphate receptor
 UniProt Gene Name    ITPR1 [Similar Products]
 UniProt Synonym Gene Names    INSP3R1; IP3R 1; InsP3R1; Type 1 InsP3 receptor [Similar Products]
 UniProt Entry Name    ITPR1_HUMAN
Section Bar
 NCBI Summary for ITPR1    This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Section Bar
 UniProt Comments for ITPR1    IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.

Protein type: Channel, ligand-gated; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: endoplasmic reticulum membrane; membrane; sarcoplasmic reticulum; endoplasmic reticulum; postsynaptic density; nucleolus; integral to membrane; nuclear inner membrane; platelet dense granule membrane; calcineurin complex

Molecular Function: protein binding; calcium ion transmembrane transporter activity; calcium channel inhibitor activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of calcium-mediated signaling; platelet activation; inositol phosphate-mediated signaling; voluntary musculoskeletal movement; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; post-embryonic development; endoplasmic reticulum calcium ion homeostasis; phospholipase C activation; calcium ion transport; release of sequestered calcium ion into cytosol; energy reserve metabolic process; response to hypoxia; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion
Table BarTOPTable Bar
 Research Articles on ITPR1    1. These data indicate that imiquimod triggers IP3 receptor-dependent Ca(2+) signaling independently of TLR7.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-ITPR1 antibodyPathways associated with anti-ITPR1 antibody
 Reference Product  PubMed Publications
 TRPC3 antibody  >23 publications with ITPR1 and TRPC3
 FYN antibody  >5 publications with ITPR1 and FYN
 TRPC1 antibody  >5 publications with ITPR1 and TRPC1
 CABP1 antibody  >3 publications with ITPR1 and CABP1
 MRVI1 antibody  >3 publications with ITPR1 and MRVI1
 CALM1 antibody  >1 publications with ITPR1 and CALM1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-ITPR1 antibodyOrgans/Tissues associated with anti-ITPR1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >66 publications with ITPR1 and Nervous System Diseases
 Brain Diseases Antibodies  >58 publications with ITPR1 and Brain Diseases
 Heart Diseases Antibodies  >14 publications with ITPR1 and Heart Diseases
 Atrophy Antibodies  >12 publications with ITPR1 and Atrophy
 Necrosis Antibodies  >11 publications with ITPR1 and Necrosis
 Movement Disorders Antibodies  >9 publications with ITPR1 and Movement Disorders
 Disease Models, Animal Antibodies  >7 publications with ITPR1 and Disease Models, Animal
 Inflammation Antibodies  >5 publications with ITPR1 and Inflammation
 Liver Diseases Antibodies  >5 publications with ITPR1 and Liver Diseases
 Nerve Degeneration Antibodies  >4 publications with ITPR1 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >130 publications with ITPR1 and Brain
 Blood Antibodies  >95 publications with ITPR1 and Blood
 Muscle Antibodies  >84 publications with ITPR1 and Muscle
 Vascular Antibodies  >39 publications with ITPR1 and Vascular
 Nerve Antibodies  >37 publications with ITPR1 and Nerve
 Kidney Antibodies  >23 publications with ITPR1 and Kidney
 Liver Antibodies  >14 publications with ITPR1 and Liver
 Lung Antibodies  >11 publications with ITPR1 and Lung
 Pancreas Antibodies  >11 publications with ITPR1 and Pancreas
 Embryonic Tissue Antibodies  >10 publications with ITPR1 and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions