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anti-INPP5D antibody :: Rabbit inositol polyphosphate-5-phosphatase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714285 anti-INPP5D antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

inositol polyphosphate-5-phosphatase (INPP5D), Polyclonal Antibody

 Also Known As   

Rabbit anti-human inositol polyphosphate-5-phosphatase, 72 kDa polyclonal Antibody

 Product Synonym Names    inositol polyphosphate-5-phosphatase; 72 kDa; INPP5E; MGC117201; PPI5PIV
 Product Gene Name   

anti-INPP5D antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601582
 3D Structure    ModBase 3D Structure for Q92835
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human INPP5E
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161086
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-INPP5D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-INPP5D antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for INPP5D. It may not necessarily be applicable to this product.
 NCBI GI #    1495456
 NCBI GeneID    3635
 NCBI Accession #    CAA67071.1 [Other Products]
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 UniProt Primary Accession #    Q92835 [Other Products]
 UniProt Secondary Accession #    O00145; Q13544; Q13545; Q6P5A4; Q92656; Q9UE80 [Other Products]
 UniProt Related Accession #    Q92835 [Other Products]
 Molecular Weight    109,294 Da [Similar Products]
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 NCBI Official Full Name    inositol polyphosphate 5- phosphatase
 NCBI Official Synonym Full Names    inositol polyphosphate-5-phosphatase, 145kDa
 NCBI Official Symbol    INPP5D [Similar Products]
 NCBI Official Synonym Symbols   
SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship
[Similar Products]
 NCBI Protein Information    phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; inositol polyphosphate-5-phosphatase, 145kD; SH2 domain-containing inositol 5'-phosphatase 1; signaling inositol polyphosphate phosphatase SHIP II; signaling inositol polyphosphate 5 phosphatase SIP-145
 UniProt Protein Name    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1
 UniProt Synonym Protein Names   
Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1; p150Ship; hp51CN
 Protein Family    Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase
 UniProt Gene Name    INPP5D [Similar Products]
 UniProt Synonym Gene Names    SHIP; SHIP1; SIP-145; SH2 domain-containing inositol phosphatase 1; SHIP-1; hp51CN [Similar Products]
 UniProt Entry Name    SHIP1_HUMAN
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 NCBI Summary for INPP5D    This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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 UniProt Comments for INPP5D    SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.

Protein type: EC 3.1.3.86; Phosphatase, lipid; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q37.1

Cellular Component: membrane; cytosol

Molecular Function: protein binding; inositol-polyphosphate 5-phosphatase activity; SH3 domain binding

Biological Process: inositol phosphate metabolic process; apoptosis; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; blood coagulation; signal transduction; T cell receptor signaling pathway; leukocyte migration; phosphate metabolic process
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 Research Articles on INPP5D    1. Tks5 is needed for breast carcinoma cell invadopodium precursor stabilization, where the phox homology (PX) domain of Tks5 interacts with PI(3,4)P2. SHIP2 arrival at the invadopodium precursor coincides with the onset of PI(3,4)P2 accumulation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INPP5D antibodyPathways associated with anti-INPP5D antibody
 Reference Product  PubMed Publications
 PTPN11 antibody  >1 publications with INPP5D and PTPN11
 GRB2 antibody  >1 publications with INPP5D and GRB2
 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
Diseases associated with anti-INPP5D antibodyOrgans/Tissues associated with anti-INPP5D antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with INPP5D and Nervous System Diseases
 Inflammation Antibodies  >3 publications with INPP5D and Inflammation
 Carcinoma Antibodies  >2 publications with INPP5D and Carcinoma
 Cardiovascular Diseases Antibodies  >2 publications with INPP5D and Cardiovascular Diseases
 Death Antibodies  >2 publications with INPP5D and Death
 Fibrosis Antibodies  >1 publications with INPP5D and Fibrosis
 Liver Cirrhosis Antibodies  >1 publications with INPP5D and Liver Cirrhosis
 Liver Diseases Antibodies  >1 publications with INPP5D and Liver Diseases
 Hypertension Antibodies  >1 publications with INPP5D and Hypertension
 Brain Diseases Antibodies  >1 publications with INPP5D and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >7 publications with INPP5D and Blood
 Bone Antibodies  >2 publications with INPP5D and Bone
 Spleen Antibodies  >2 publications with INPP5D and Spleen
 Heart Antibodies  >2 publications with INPP5D and Heart
 Lymph Antibodies  >1 publications with INPP5D and Lymph
 Bone Marrow Antibodies  >1 publications with INPP5D and Bone Marrow
 Lung Antibodies  >1 publications with INPP5D and Lung
 Brain Antibodies  >1 publications with INPP5D and Brain
 Lymph Node Antibodies  >1 publications with INPP5D and Lymph Node
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