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anti-INTS3 antibody :: Rabbit integrator complex subunit 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710662 anti-INTS3 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

integrator complex subunit 3 (INTS3), Polyclonal Antibody

 Also Known As   

Rabbit anti-human integrator complex subunit 3 polyclonal Antibody

 Product Synonym Names    integrator complex subunit 3; INTS3; C1orf193; C1orf60; DKFZp686E1950; DKFZp686O20115; DKFZp781I1253; FLJ21919; FLJ44849; INT3
 Product Gene Name   

anti-INTS3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    611347
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human INTS3
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-138355
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-INTS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-INTS3 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for INTS3. It may not necessarily be applicable to this product.
 NCBI GI #    39995084
 NCBI GeneID    65123
 NCBI Accession #    NP_075391.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_023015.3 [Other Products]
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 UniProt Secondary Accession #    Q4G0E5; Q5VUQ5; Q5VUQ6; Q5VUR0; Q5VUR1; Q68DJ1; Q69YR5; A8K1W0; B4DQC8; B4E3U9; D3DV57 [Other Products]
 UniProt Related Accession #    Q68E01 [Other Products]
 Molecular Weight    63,586 Da [Similar Products]
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 NCBI Official Full Name    integrator complex subunit 3
 NCBI Official Synonym Full Names    integrator complex subunit 3
 NCBI Official Symbol    INTS3 [Similar Products]
 NCBI Official Synonym Symbols   
INT3; SOSSA; SOSS-A; C1orf60; C1orf193
[Similar Products]
 NCBI Protein Information    integrator complex subunit 3; sensor of ssDNA A; SOSS complex subunit A; sensor of ssDNA subunit A; sensor of single-strand DNA complex subunit A
 UniProt Protein Name    Integrator complex subunit 3
 UniProt Synonym Protein Names   
SOSS complex subunit A; Sensor of single-strand DNA complex subunit A; SOSS-A; Sensor of ssDNA subunit A
 Protein Family    Integrator complex
 UniProt Gene Name    INTS3 [Similar Products]
 UniProt Synonym Gene Names    C1orf193; C1orf60; Int3; SOSS-A; Sensor of ssDNA subunit A [Similar Products]
 UniProt Entry Name    INT3_HUMAN
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 NCBI Summary for INTS3    INTS3 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]). INTS3 is also a subunit of single-stranded DNA (ssDNA)-binding complexes involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]
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 UniProt Comments for INTS3    INTS3: Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Belongs to the Integrator subunit 3 family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: nucleus; integrator complex

Molecular Function: protein binding

Biological Process: mitotic cell cycle checkpoint; snRNA processing; response to ionizing radiation; DNA repair; response to DNA damage stimulus
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 Research Articles on INTS3    1. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-INTS3 antibodyOrgans/Tissues associated with anti-INTS3 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >1 publications with INTS3 and Breast Neoplasms
 Liver Diseases Antibodies  >1 publications with INTS3 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >1 publications with INTS3 and Kidney
 Liver Antibodies  >1 publications with INTS3 and Liver
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