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anti-IFNAR2 antibody :: Rabbit anti-Human interferon (alpha, beta and omega) receptor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716960 anti-IFNAR2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

interferon (alpha, beta and omega) receptor 2 (IFNAR2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human interferon (alpha, beta and omega) receptor 2 polyclonal Antibody

 Product Synonym Names    interferon (alpha; beta and omega) receptor 2; IFNAR2; IFN-R; IFN-alpha-REC; IFNABR; IFNARB
 Product Gene Name   

anti-IFNAR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610424
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human IFNAR2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-83256 / sc-83257 / sc-83258 / sc-704 / sc-30014
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IFNAR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IFNAR2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for IFNAR2. It may not necessarily be applicable to this product.
 NCBI GI #    119630251
 NCBI GeneID    3455
 NCBI Accession #    EAX09846.1 [Other Products]
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 UniProt Secondary Accession #    Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9 [Other Products]
 UniProt Related Accession #    P48551 [Other Products]
 Molecular Weight    27,384 Da [Similar Products]
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 NCBI Official Full Name    interferon (alpha, beta and omega) receptor 2, isoform CRA_b
 NCBI Official Synonym Full Names    interferon (alpha, beta and omega) receptor 2
 NCBI Official Symbol    IFNAR2 [Similar Products]
 NCBI Official Synonym Symbols   
IFN-R; IFNABR; IFNARB; IFN-alpha-REC
[Similar Products]
 NCBI Protein Information    interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain
 UniProt Protein Name    Interferon alpha/beta receptor 2
 UniProt Synonym Protein Names   
Interferon alpha binding protein; Type I interferon receptor 2
 Protein Family    Interferon alpha/beta receptor
 UniProt Gene Name    IFNAR2 [Similar Products]
 UniProt Synonym Gene Names    IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2 [Similar Products]
 UniProt Entry Name    INAR2_HUMAN
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 NCBI Summary for IFNAR2    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. Multiple transcript variants encoding at least two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNAR2    IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; extracellular region; plasma membrane

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To
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 Research Articles on IFNAR2    1. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNAR2 antibodyPathways associated with anti-IFNAR2 antibody
 Reference Product  PubMed Publications
 IFNA2 antibody  >195 publications with IFNAR2 and IFNA2
 IFNAR1 antibody  >149 publications with IFNAR2 and IFNAR1
 STAT1 antibody  >35 publications with IFNAR2 and STAT1
 STAT2 antibody  >26 publications with IFNAR2 and STAT2
 JAK1 antibody  >25 publications with IFNAR2 and JAK1
 TYK2 antibody  >23 publications with IFNAR2 and TYK2
 GNB2L1 antibody  >2 publications with IFNAR2 and GNB2L1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
Diseases associated with anti-IFNAR2 antibodyOrgans/Tissues associated with anti-IFNAR2 antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >30 publications with IFNAR2 and Liver Diseases
 Carcinoma Antibodies  >25 publications with IFNAR2 and Carcinoma
 Nervous System Diseases Antibodies  >17 publications with IFNAR2 and Nervous System Diseases
 Adenocarcinoma Antibodies  >15 publications with IFNAR2 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >14 publications with IFNAR2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >11 publications with IFNAR2 and Inflammation
 Necrosis Antibodies  >9 publications with IFNAR2 and Necrosis
 Liver Neoplasms Antibodies  >8 publications with IFNAR2 and Liver Neoplasms
 Hepatitis B Antibodies  >8 publications with IFNAR2 and Hepatitis B
 Cardiovascular Diseases Antibodies  >6 publications with IFNAR2 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >51 publications with IFNAR2 and Blood
 Liver Antibodies  >32 publications with IFNAR2 and Liver
 Lung Antibodies  >9 publications with IFNAR2 and Lung
 Bone Marrow Antibodies  >7 publications with IFNAR2 and Bone Marrow
 Brain Antibodies  >6 publications with IFNAR2 and Brain
 Kidney Antibodies  >6 publications with IFNAR2 and Kidney
 Uterus Antibodies  >6 publications with IFNAR2 and Uterus
 Spleen Antibodies  >5 publications with IFNAR2 and Spleen
 Lymph Node Antibodies  >2 publications with IFNAR2 and Lymph Node
 Intestine Antibodies  >2 publications with IFNAR2 and Intestine
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