EAW89041.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
NCBI Official Synonym Full Names
karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
NCBI Protein Information
importin subunit alpha-1; pendulin; SRP1-alpha; RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; RAG cohort protein 1; importin subunit alpha-2; karyopherin subunit alpha-2
UniProt Protein Name
Importin subunit alpha-1
UniProt Synonym Protein Names
Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha
UniProt Synonym Gene Names
UniProt Entry Name
IMA1_HUMAN
NCBI Summary for KPNA2
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008]
UniProt Comments for KPNA2
KPNA2: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family.
Protein type: Nuclear import; Nucleoporin; Karyopherin
Chromosomal Location of Human Ortholog: 17q24.2
Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol
Molecular Function: protein binding; histone deacetylase binding; nuclear localization sequence binding; protein transporter activity
Biological Process: viral reproduction; regulation of DNA recombination; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus; DNA metabolic process
Research Articles on KPNA2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-KPNA2 antibody
Pathways associated with anti-KPNA2 antibody
Diseases associated with anti-KPNA2 antibody
Organs/Tissues associated with anti-KPNA2 antibody
|