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anti-KATNA1 antibody :: Rabbit katanin p60 (ATPase-containing) subunit A 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712442 anti-KATNA1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

katanin p60 (ATPase-containing) subunit A 1 (KATNA1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human katanin p60 (ATPase-containing) subunit A 1 polyclonal Antibody

 Product Synonym Names    katanin p60 (ATPase-containing) subunit A 1;
 Product Gene Name   

anti-KATNA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606696
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human KATNA1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-109299 / sc-109298 / sc-109302
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KATNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KATNA1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for KATNA1. It may not necessarily be applicable to this product.
 NCBI GI #    5901990
 NCBI GeneID    11104
 NCBI Accession #    NP_008975.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007044.3 [Other Products]
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 UniProt Secondary Accession #    Q5TFA8; Q5TFA9; Q86VN2; Q9NU52; E1P5A3 [Other Products]
 UniProt Related Accession #    O75449 [Other Products]
 Molecular Weight    35,319 Da [Similar Products]
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 NCBI Official Full Name    katanin p60 ATPase-containing subunit A1 isoform 1
 NCBI Official Synonym Full Names    katanin p60 (ATPase containing) subunit A 1
 NCBI Official Symbol    KATNA1 [Similar Products]
 NCBI Protein Information    katanin p60 ATPase-containing subunit A1; KATNA1; p60 katanin; katanin p60 subunit A1; katanin p60 (ATPase-containing) subunit A 1
 UniProt Protein Name    Katanin p60 ATPase-containing subunit A1
 UniProt Synonym Protein Names   
p60 katanin
 UniProt Gene Name    KATNA1 [Similar Products]
 UniProt Synonym Gene Names    Katanin p60 subunit A1 [Similar Products]
 UniProt Entry Name    KTNA1_HUMAN
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 NCBI Summary for KATNA1    Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2011]
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 UniProt Comments for KATNA1    KATNA1: Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth. Belongs to the AAA ATPase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; Motility/polarity/chemotaxis; EC 3.6.4.3

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: nucleoplasm; spindle pole; centrosome; microtubule; growth cone; cell soma; axon; cytoplasm; plasma membrane; microtubule organizing center; spindle; lipid particle; midbody; nucleus

Molecular Function: dynein binding; protein binding; protein heterodimerization activity; microtubule binding; microtubule-severing ATPase activity; ATP binding

Biological Process: mitosis; protein localization; cell division; metabolic process; microtubule severing; neuron migration; microtubule bundle formation; cytoplasmic microtubule organization and biogenesis
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 Research Articles on KATNA1    1. analysis of spastin's microtubule-binding properties and comparison with katanin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KATNA1 antibodyPathways associated with anti-KATNA1 antibody
 Reference Product  PubMed Publications
 KATNB1 antibody  >1 publications with KATNA1 and KATNB1
 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
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