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anti-LINGO1 antibody :: Rabbit leucine rich repeat and Ig domain containing 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711412 anti-LINGO1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

leucine rich repeat and Ig domain containing 1 (LINGO1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human leucine rich repeat and Ig domain containing 1 polyclonal Antibody

 Product Synonym Names    leucine rich repeat and Ig domain containing 1; LINGO1; FLJ14594; LERN1; LRRN6A; MGC17422; UNQ201
 Product Gene Name   

anti-LINGO1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609791
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human LINGO1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LINGO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LINGO1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for LINGO1. It may not necessarily be applicable to this product.
 NCBI GI #    51512605
 NCBI GeneID    84894
 NCBI Accession #    AAH11057.2 [Other Products]
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 UniProt Secondary Accession #    Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80 [Other Products]
 UniProt Related Accession #    Q96FE5 [Other Products]
 Molecular Weight    69,146 Da [Similar Products]
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 NCBI Official Full Name    Leucine rich repeat and Ig domain containing 1
 NCBI Official Synonym Full Names    leucine rich repeat and Ig domain containing 1
 NCBI Official Symbol    LINGO1 [Similar Products]
 NCBI Official Synonym Symbols   
LERN1; LRRN6A; UNQ201
[Similar Products]
 NCBI Protein Information    leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
 UniProt Protein Name    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
 UniProt Synonym Protein Names   
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
 Protein Family    Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
 UniProt Gene Name    LINGO1 [Similar Products]
 UniProt Synonym Gene Names    LERN1; LRRN6A [Similar Products]
 UniProt Entry Name    LIGO1_HUMAN
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 UniProt Comments for LINGO1    LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
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 Research Articles on LINGO1    1. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-LINGO1 antibodyPathways associated with anti-LINGO1 antibody
 Reference Product  PubMed Publications
 RTN4R antibody  >11 publications with LINGO1 and RTN4R
 TNFRSF19 antibody  >9 publications with LINGO1 and TNFRSF19
 OMG antibody  >3 publications with LINGO1 and OMG
 EGFR antibody  >2 publications with LINGO1 and EGFR
 HS1BP3 antibody  >1 publications with LINGO1 and HS1BP3
 LINGO3 antibody  >1 publications with LINGO1 and LINGO3
 DRD3 antibody  >1 publications with LINGO1 and DRD3
 NGFR antibody  >1 publications with LINGO1 and NGFR
 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 P75NTR Regulates Axonogenesis Pathway antibodies  P75NTR Regulates Axonogenesis Pathway Diagram
Diseases associated with anti-LINGO1 antibodyOrgans/Tissues associated with anti-LINGO1 antibody
 Disease Name  Pubmed Publications
 Essential Tremor Antibodies  >35 publications with LINGO1 and Essential Tremor
 Disease Models, Animal Antibodies  >14 publications with LINGO1 and Disease Models, Animal
 Necrosis Antibodies  >9 publications with LINGO1 and Necrosis
 Inflammation Antibodies  >3 publications with LINGO1 and Inflammation
 Abnormalities, Multiple Antibodies  >1 publications with LINGO1 and Abnormalities, Multiple
 Neoplasms, Experimental Antibodies  >1 publications with LINGO1 and Neoplasms, Experimental
 Cognition Disorders Antibodies  >1 publications with LINGO1 and Cognition Disorders
 Learning Disorders Antibodies  >1 publications with LINGO1 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with LINGO1 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with LINGO1 and Brain
 Ganglia Antibodies  >10 publications with LINGO1 and Ganglia
 Embryonic Tissue Antibodies  >7 publications with LINGO1 and Embryonic Tissue
 Eye Antibodies  >6 publications with LINGO1 and Eye
 Ovary Antibodies  >1 publications with LINGO1 and Ovary
 Uncharacterized Tissue Antibodies  >1 publications with LINGO1 and Uncharacterized Tissue
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