AAH11057.2
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Leucine rich repeat and Ig domain containing 1
NCBI Official Synonym Full Names
leucine rich repeat and Ig domain containing 1
NCBI Protein Information
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1
UniProt Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
UniProt Synonym Gene Names
UniProt Entry Name
LIGO1_HUMAN
UniProt Comments for LINGO1
LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 15q24.3
Cellular Component: plasma membrane; integral to membrane
Molecular Function: epidermal growth factor receptor binding
Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
Research Articles on LINGO1
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Products associated with anti-LINGO1 antibody
Pathways associated with anti-LINGO1 antibody
Diseases associated with anti-LINGO1 antibody
Organs/Tissues associated with anti-LINGO1 antibody
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