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anti-PIDD1 antibody :: Rabbit leucine-rich repeats and death domain containing Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716209 anti-PIDD1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

leucine-rich repeats and death domain containing (PIDD1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human leucine-rich repeats and death domain containing polyclonal Antibody

 Product Synonym Names    leucine-rich repeats and death domain containing; LRDD; DKFZp434D229; MGC16925; PIDD
 Product Gene Name   

anti-PIDD1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605247
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human LRDD
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32161 / sc-32163 / sc-67032
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PIDD1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PIDD1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for PIDD1. It may not necessarily be applicable to this product.
 NCBI GI #    15928880
 NCBI GeneID    55367
 NCBI Accession #    AAH14904.1 [Other Products]
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 UniProt Secondary Accession #    Q59FD1; Q59H10; Q59HC7; Q7Z4P8; Q8NC89; Q8NDL2; Q96C25; Q9NRE6 [Other Products]
 UniProt Related Accession #    Q9HB75 [Other Products]
 Molecular Weight    33,375 Da [Similar Products]
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 NCBI Official Full Name    Leucine-rich repeats and death domain containing
 NCBI Official Synonym Full Names    p53-induced death domain protein 1
 NCBI Official Symbol    PIDD1 [Similar Products]
 NCBI Official Synonym Symbols   
LRDD; PIDD
[Similar Products]
 NCBI Protein Information    p53-induced death domain-containing protein 1; p53-induced protein with a death domain; leucine-rich repeats and death domain containing; leucine-rich repeat and death domain-containing protein
 UniProt Protein Name    p53-induced death domain-containing protein 1
 UniProt Synonym Protein Names   
Leucine-rich repeat and death domain-containing protein
 Protein Family    p53-induced death domain-containing protein
 UniProt Gene Name    PIDD1 [Similar Products]
 UniProt Synonym Gene Names    LRDD; PIDD [Similar Products]
 UniProt Entry Name    PIDD1_HUMAN
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 NCBI Summary for PIDD1    The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
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 UniProt Comments for PIDD1    PIDD: Promotes apoptosis downstream of the tumor suppressor as component of the DNA damage/stress response pathway that connects p53/TP53 to apoptosis. Associates with NEMO/IKBKG and RIP1 and enhances sumoylation and ubiquitination of NEMO/IKBKG which is important for activation of the transcription factor NF-kappa-B. Associates with CASP2/caspase-2 and CRADD/RAIDD, and induces activation of CASP2 which an important regulator in apoptotic pathways. 7 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: Golgi apparatus; cytoplasm; nucleus

Molecular Function: protein binding; death receptor binding

Biological Process: caspase activation; positive regulation of apoptosis; signal transduction; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; response to DNA damage stimulus; activation of NF-kappaB transcription factor; negative regulation of apoptosis
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 Research Articles on PIDD1    1. The ATM phosphorylation of the PIDD DD enables a binary switch through which cells elect to survive or die upon DNA injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PIDD1 antibodyOrgans/Tissues associated with anti-PIDD1 antibody
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 DNA Damage Response Pathway antibodies  DNA Damage Response Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 MiRNA Regulation Of DNA Damage Response Pathway antibodies  MiRNA Regulation Of DNA Damage Response Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with PIDD1 and Muscle
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