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anti-LPIN2 antibody :: Rabbit anti-Human lipin 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714958 anti-LPIN2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

lipin 2 (LPIN2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human lipin 2 polyclonal Antibody

 Product Synonym Names    lipin 2; LPIN2; KIAA0249
 Product Gene Name   

anti-LPIN2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609628
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human LPIN2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50053 / sc-50054
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-LPIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-LPIN2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for LPIN2. It may not necessarily be applicable to this product.
 NCBI GI #    156230164
 NCBI GeneID    9663
 NCBI Accession #    AAI52449.1 [Other Products]
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 UniProt Secondary Accession #    A7MD25; D3DUH3 [Other Products]
 UniProt Related Accession #    Q92539 [Other Products]
 Molecular Weight    99,399 Da [Similar Products]
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 NCBI Official Full Name    Lipin 2
 NCBI Official Synonym Full Names    lipin 2
 NCBI Official Symbol    LPIN2 [Similar Products]
 NCBI Protein Information    phosphatidate phosphatase LPIN2; lipin-2
 UniProt Protein Name    Phosphatidate phosphatase LPIN2
 UniProt Synonym Protein Names   
Lipin-2
 Protein Family    Phosphatidate phosphatase
 UniProt Gene Name    LPIN2 [Similar Products]
 UniProt Synonym Gene Names    KIAA0249 [Similar Products]
 UniProt Entry Name    LPIN2_HUMAN
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 NCBI Summary for LPIN2    Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
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 UniProt Comments for LPIN2    LPIN2: Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism. Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS). An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration). Belongs to the lipin family.

Protein type: Transcription, coactivator/corepressor; EC 3.1.3.4; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: 18p11.31

Cellular Component: endoplasmic reticulum membrane; nucleus; cytosol

Molecular Function: phosphatidate phosphatase activity; transcription coactivator activity

Biological Process: transcription, DNA-dependent; dephosphorylation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylethanolamine biosynthetic process; phosphatidylcholine biosynthetic process; triacylglycerol biosynthetic process; positive regulation of transcription from RNA polymerase II promoter; fatty acid catabolic process; lipid metabolic process; cellular lipid metabolic process

Disease: Majeed Syndrome
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 Research Articles on LPIN2    1. We describe two brothers with Majeed syndrome, homozygous novel 2-base pair deletion in LPIN2 (c.1312_1313delCT; p.Leu438fs+16X)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Rabbit anti-human lipin 2 polyclonal Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS418919  Anti-Lipin 2 Antibody  MBS146187  Recombinant Human Perilipin 2
 MBS9322384  Mouse Phosphatidate phosphatase LPIN2, LPIN2 ELISA Kit  MBS9342232  Human Phosphatidate phosphatase LPIN2, LPIN2 ELISA Kit
 MBS714958  Rabbit anti-human lipin 2 polyclonal Antibody  MBS9322972  Mouse Mucolipin-2, MCOLN2 ELISA Kit
 MBS843590  Lipin 2 Blocking Peptide  MBS9328505  Human Mucolipin-2, MCOLN2 ELISA Kit
 MBS426576  Lipin 2 Immunizing Peptide  MBS421303  Goat anti-Lipin 2 Antibody
Products associated with anti-LPIN2 antibodyPathways associated with anti-LPIN2 antibody
 Reference Product  PubMed Publications
 AGPAT2 antibody  >1 publications with LPIN2 and AGPAT2
 DGAT1 antibody  >1 publications with LPIN2 and DGAT1
 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Depolymerisation Of The Nuclear Lamina Pathway antibodies  Depolymerisation Of The Nuclear Lamina Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
 Glycerophospholipid Metabolism Pathway antibodies  Glycerophospholipid Metabolism Pathway Diagram
Diseases associated with anti-LPIN2 antibodyOrgans/Tissues associated with anti-LPIN2 antibody
 Disease Name  Pubmed Publications
 Majeed syndrome Antibodies  >14 publications with LPIN2 and Majeed syndrome
 Inflammation Antibodies  >11 publications with LPIN2 and Inflammation
 Fatty Liver Antibodies  >6 publications with LPIN2 and Fatty Liver
 Disease Models, Animal Antibodies  >4 publications with LPIN2 and Disease Models, Animal
 Liver Diseases Antibodies  >3 publications with LPIN2 and Liver Diseases
 Necrosis Antibodies  >3 publications with LPIN2 and Necrosis
 Lung Diseases Antibodies  >2 publications with LPIN2 and Lung Diseases
 Weight Loss Antibodies  >1 publications with LPIN2 and Weight Loss
 Poisoning Antibodies  >1 publications with LPIN2 and Poisoning
 Weight Gain Antibodies  >1 publications with LPIN2 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >12 publications with LPIN2 and Bone
 Liver Antibodies  >12 publications with LPIN2 and Liver
 Blood Antibodies  >9 publications with LPIN2 and Blood
 Muscle Antibodies  >8 publications with LPIN2 and Muscle
 Skin Antibodies  >8 publications with LPIN2 and Skin
 Connective Tissue Antibodies  >5 publications with LPIN2 and Connective Tissue
 Lung Antibodies  >5 publications with LPIN2 and Lung
 Heart Antibodies  >3 publications with LPIN2 and Heart
 Kidney Antibodies  >3 publications with LPIN2 and Kidney
 Eye Antibodies  >2 publications with LPIN2 and Eye
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