AAH92463.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Lysophosphatidylcholine acyltransferase 4
NCBI Official Synonym Full Names
lysophosphatidylcholine acyltransferase 4
NCBI Official Synonym Symbols
AYTL3; AGPAT7; LPEAT2; LPAAT-eta [Similar Products]
NCBI Protein Information
lysophospholipid acyltransferase LPCAT4; 1-AGPAT 7; plasmalogen synthase; acyltransferase like 3; acyltransferase-like 3; 1-AGP acyltransferase 7; PLSC domain containing protein; 1-acylglycerophosphoserine O-acyltransferase; 1-acylglycerophosphocholine O-acyltransferase; lysophosphatidylethanolamine acyltransferase 2; 1-alkylglycerophosphocholine O-acetyltransferase; 1-alkenylglycerophosphoethanolamine O-acyltransferase; acyl-CoA:lysophosphatidylethanolamine acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)
UniProt Protein Name
Lysophospholipid acyltransferase LPCAT4
UniProt Synonym Protein Names
1-acylglycerol-3-phosphate O-acyltransferase 7; 1-AGP acyltransferase 7; 1-AGPAT 7; 1-acylglycerophosphocholine O-acyltransferase (EC:2.3.1.23); 1-acylglycerophosphoserine O-acyltransferase (EC:2.3.1.n6); 1-alkenylglycerophosphoethanolamine O-acyltransferase (EC:2.3.1.121); 1-alkylglycerophosphocholine O-acetyltransferase (EC:2.3.1.67); Acyltransferase-like 3; Lysophosphatidylcholine acyltransferase 4; Lysophosphatidylethanolamine acyltransferase 2 (EC:2.3.1.n7); Plasmalogen synthase
UniProt Synonym Gene Names
UniProt Entry Name
LPCT4_HUMAN
NCBI Summary for LPCAT4
Members of the 1-acylglycerol-3-phosphate O-acyltransferase (EC 2.3.1.51) family, such as AGPAT7, catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA), a precursor in the biosynthesis of all glycerolipids. Both LPA and PA are involved in signal transduction (Ye et al., 2005 [PubMed 16243729]).[supplied by OMIM, May 2008]
UniProt Comments for LPCAT4
AGPAT7: Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
Protein type: EC 2.3.1.23; Transferase; EC 2.3.1.n6; EC 2.3.1.n7; Membrane protein, multi-pass; Membrane protein, integral; EC 2.3.1.67; EC 2.3.1.121
Chromosomal Location of Human Ortholog: 15q14
Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane
Molecular Function: 1-alkylglycerophosphocholine O-acetyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-alkenylglycerophosphoethanolamine O-acyltransferase activity
Biological Process: phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidic acid biosynthetic process; triacylglycerol biosynthetic process; cellular lipid metabolic process
Research Articles on LPCAT4
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Products associated with anti-LPCAT4 antibody
Pathways associated with anti-LPCAT4 antibody
Diseases associated with anti-LPCAT4 antibody
Organs/Tissues associated with anti-LPCAT4 antibody
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