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anti-MBD3 antibody :: Rabbit methyl-CpG binding domain protein 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711747 anti-MBD3 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

methyl-CpG binding domain protein 3 (MBD3), Polyclonal Antibody

 Also Known As   

Rabbit anti-human methyl-CpG binding domain protein 3 polyclonal Antibody

 Product Synonym Names    methyl-CpG binding domain protein 3;
 Product Gene Name   

anti-MBD3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603573
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human MBD3
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9400 / sc-9402 / sc-28743
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MBD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MBD3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for MBD3. It may not necessarily be applicable to this product.
 NCBI GI #    50400820
 NCBI GeneID    53615
 NCBI Accession #    O95983.1 [Other Products]
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 UniProt Secondary Accession #    Q6PIL9; Q6PJZ9; Q86XF4; A8K4B7; D6W5Z2 [Other Products]
 UniProt Related Accession #    O95983 [Other Products]
 Molecular Weight    29,014 Da [Similar Products]
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 NCBI Official Full Name    Methyl-CpG-binding domain protein 3
 NCBI Official Synonym Full Names    methyl-CpG binding domain protein 3
 NCBI Official Symbol    MBD3 [Similar Products]
 NCBI Protein Information    methyl-CpG-binding domain protein 3
 UniProt Protein Name    Methyl-CpG-binding domain protein 3
 UniProt Synonym Protein Names   
Methyl-CpG-binding protein MBD3
 Protein Family    Methyl-CpG-binding domain protein
 UniProt Gene Name    MBD3 [Similar Products]
 UniProt Entry Name    MBD3_HUMAN
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 NCBI Summary for MBD3    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
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 UniProt Comments for MBD3    MBD3: methyl-CpG binding (MBD) proteins appear to bind differentially methylated domains (DMDs) of DNA, to recruit repression complexes, and to silence the locus. The methyl CpG binding domain of human MBD3 may not directly bind mCpG but does interact with the NuRD/Mi2 components HDAC1 and MTA2. Plays a role in histone deacetylation and nucleosome remodeling. Increased levels have been reported in lung cancer and glioblastomas and may be a therapeutic target.

Protein type: Gene silencing; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; heterochromatin; protein complex; nuclear chromatin; cytoplasm; NuRD complex

Molecular Function: protein binding; nucleosomal DNA binding; DNA binding; methyl-CpG binding

Biological Process: tissue development; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; methylation-dependent chromatin silencing; in utero embryonic development; ATP-dependent chromatin remodeling; histone acetylation; negative regulation of transcription from RNA polymerase II promoter
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 Research Articles on MBD3    1. These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MBD3 antibodyPathways associated with anti-MBD3 antibody
 Reference Product  PubMed Publications
 MBD2 antibody  >68 publications with MBD3 and MBD2
 HDAC1 antibody  >19 publications with MBD3 and HDAC1
 HDAC2 antibody  >9 publications with MBD3 and HDAC2
 CHD4 antibody  >8 publications with MBD3 and CHD4
 MTA1 antibody  >7 publications with MBD3 and MTA1
 MTA2 antibody  >7 publications with MBD3 and MTA2
 RBBP7 antibody  >3 publications with MBD3 and RBBP7
 GATAD2A antibody  >2 publications with MBD3 and GATAD2A
 RBBP4 antibody  >2 publications with MBD3 and RBBP4
 GATAD2B antibody  >2 publications with MBD3 and GATAD2B
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 HDACs Deacetylate Histones Pathway antibodies  HDACs Deacetylate Histones Pathway Diagram
 RNA Polymerase I Promoter Clearance Pathway antibodies  RNA Polymerase I Promoter Clearance Pathway Diagram
 RNA Polymerase I Transcription Pathway antibodies  RNA Polymerase I Transcription Pathway Diagram
 RNA Polymerase I Transcription Initiation Pathway antibodies  RNA Polymerase I Transcription Initiation Pathway Diagram
 RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway antibodies  RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
Diseases associated with anti-MBD3 antibodyOrgans/Tissues associated with anti-MBD3 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >8 publications with MBD3 and Disease Models, Animal
 Nervous System Diseases Antibodies  >6 publications with MBD3 and Nervous System Diseases
 Carcinoma Antibodies  >5 publications with MBD3 and Carcinoma
 Lung Neoplasms Antibodies  >4 publications with MBD3 and Lung Neoplasms
 Liver Neoplasms Antibodies  >2 publications with MBD3 and Liver Neoplasms
 Carcinoma, Hepatocellular Antibodies  >2 publications with MBD3 and Carcinoma, Hepatocellular
 Breast Neoplasms Antibodies  >2 publications with MBD3 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with MBD3 and Neoplasm Metastasis
 Inflammation Antibodies  >2 publications with MBD3 and Inflammation
 Autistic Disorder Antibodies  >2 publications with MBD3 and Autistic Disorder
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >14 publications with MBD3 and Brain
 Blood Antibodies  >12 publications with MBD3 and Blood
 Skin Antibodies  >11 publications with MBD3 and Skin
 Lung Antibodies  >7 publications with MBD3 and Lung
 Liver Antibodies  >7 publications with MBD3 and Liver
 Embryonic Tissue Antibodies  >5 publications with MBD3 and Embryonic Tissue
 Nerve Antibodies  >5 publications with MBD3 and Nerve
 Testis Antibodies  >4 publications with MBD3 and Testis
 Connective Tissue Antibodies  >2 publications with MBD3 and Connective Tissue
 Spleen Antibodies  >2 publications with MBD3 and Spleen
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