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anti-MAPK11 antibody :: Rabbit mitogen-activated protein kinase 11 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713101 anti-MAPK11 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

mitogen-activated protein kinase 11 (MAPK11), Polyclonal Antibody

 Also Known As   

Rabbit anti-human mitogen-activated protein kinase 11 polyclonal Antibody

 Product Synonym Names    mitogen-activated protein kinase 11; MAPK11; P38B; P38BETA2; PRKM11; SAPK2; SAPK2B; p38-2; p38Beta
 Product Gene Name   

anti-MAPK11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602898
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human MAPK11
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6176 / sc-15918 / sc-6187
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MAPK11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MAPK11 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for MAPK11. It may not necessarily be applicable to this product.
 NCBI GI #    20128774
 NCBI GeneID    5600
 NCBI Accession #    NP_002742.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_002751.6 [Other Products]
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 UniProt Secondary Accession #    O00284; O15472; Q2XNF2; A8K730; B0LPG1; B7Z630; E7ETQ1; L7RT27 [Other Products]
 UniProt Related Accession #    Q15759 [Other Products]
 Molecular Weight    23,603 Da [Similar Products]
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 NCBI Official Full Name    mitogen-activated protein kinase 11
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 11
 NCBI Official Symbol    MAPK11 [Similar Products]
 NCBI Official Synonym Symbols   
P38B; SAPK2; p38-2; PRKM11; SAPK2B; p38Beta; P38BETA2
[Similar Products]
 NCBI Protein Information    mitogen-activated protein kinase 11; MAP kinase 11; MAP kinase p38 beta; stress-activated protein kinase-2; stress-activated protein kinase-2b; mitogen-activated protein kinase p38-2; mitogen-activated protein kinase p38 beta
 UniProt Protein Name    Mitogen-activated protein kinase 11
 UniProt Synonym Protein Names   
Mitogen-activated protein kinase p38 beta; MAP kinase p38 beta; p38b; Stress-activated protein kinase 2b; SAPK2b; p38-2
 Protein Family    Mitogen-activated protein kinase
 UniProt Gene Name    MAPK11 [Similar Products]
 UniProt Synonym Gene Names    PRKM11; SAPK2; SAPK2B; MAP kinase 11; MAPK 11; MAP kinase p38 beta; p38b; SAPK2b [Similar Products]
 UniProt Entry Name    MK11_HUMAN
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 NCBI Summary for MAPK11    This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
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 UniProt Comments for MAPK11    P38B: a proline-directed ser/thr MAP kinase, and one of four p38 kinases that play important roles in cellular responses to inflammatory cytokines, DNA damage, oxidative stress, and some GPCRs, leading to direct activation of transcription factors and of other downstream kinases including MSK1, MSK2, eEF2K, MK2, and PRAK. MSK1 and -2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli. MK2 and -3 control gene expression mostly at the post-transcriptional level. eEF2K is important for the elongation of mRNA during translation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17, which then cleaves the ectodomain of TGF-alpha family ligands, a process leading to the activation of EGFR signaling and cell proliferation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, CHOPO, p53 and MEF2C and MEF2A. The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers. The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. Interacts directly with HDAC3 interacts directly and selectively to repress ATF2 transcriptional activity, and regulate TNF gene expression in LPS-stimulated cells. Inhibited by SB203580 and pyridinyl-imidazole related compounds.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC; Protein kinase, CMGC; Kinase, protein; CMGC group; MAPK family; p38 subfamily; MAPK/p38 subfamily

Chromosomal Location of Human Ortholog: 22q13.33

Cellular Component: nucleoplasm; cytosol

Molecular Function: MAP kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding

Biological Process: mitochondrion organization and biogenesis; transcription, DNA-dependent; nerve growth factor receptor signaling pathway; activation of MAPK activity; MyD88-independent toll-like receptor signaling pathway; organelle organization and biogenesis; stress-activated MAPK cascade; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; toll-like receptor 2 signaling pathway; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; muscle cell differentiation; regulation of transcription factor activity; Ras protein signal transduction; toll-like receptor signaling pathway; innate immune response; positive regulation of muscle cell differentiation; response to stress; gene expression; toll-like receptor 9 signaling pathway; vascular endothelial growth factor receptor signaling pathway; toll-like receptor 4 signaling pathway
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 Research Articles on MAPK11    1. Study identifies Hsp27 as a novel target of ILK-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPK11 antibodyPathways associated with anti-MAPK11 antibody
 Reference Product  PubMed Publications
 JUN antibody  >1 publications with MAPK11 and JUN
 ATF2 antibody  >1 publications with MAPK11 and ATF2
 Products by Pathway  Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway antibodies  Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway Diagram
 Activation Of The AP-1 Family Of Transcription Factors Pathway antibodies  Activation Of The AP-1 Family Of Transcription Factors Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 CD40/CD40L Signaling Pathway antibodies  CD40/CD40L Signaling Pathway Diagram
 CDO In Myogenesis Pathway antibodies  CDO In Myogenesis Pathway Diagram
Diseases associated with anti-MAPK11 antibodyOrgans/Tissues associated with anti-MAPK11 antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with MAPK11 and Adenocarcinoma
 Kidney Diseases Antibodies  >2 publications with MAPK11 and Kidney Diseases
 Inflammation Antibodies  >2 publications with MAPK11 and Inflammation
 Necrosis Antibodies  >2 publications with MAPK11 and Necrosis
 Liver Diseases Antibodies  >1 publications with MAPK11 and Liver Diseases
 Neoplasm Metastasis Antibodies  >1 publications with MAPK11 and Neoplasm Metastasis
 Carcinoma, Hepatocellular Antibodies  >1 publications with MAPK11 and Carcinoma, Hepatocellular
 Atherosclerosis Antibodies  >1 publications with MAPK11 and Atherosclerosis
 Neoplasms, Experimental Antibodies  >1 publications with MAPK11 and Neoplasms, Experimental
 Heart Diseases Antibodies  >1 publications with MAPK11 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with MAPK11 and Blood
 Placenta Antibodies  >3 publications with MAPK11 and Placenta
 Vascular Antibodies  >1 publications with MAPK11 and Vascular
 Liver Antibodies  >1 publications with MAPK11 and Liver
 Spleen Antibodies  >1 publications with MAPK11 and Spleen
 Brain Antibodies  >1 publications with MAPK11 and Brain
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