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anti-MYH10 antibody :: Rabbit myosin, heavy chain 10, non-muscle Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716460 anti-MYH10 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

myosin, heavy chain 10, non-muscle (MYH10), Polyclonal Antibody

 Also Known As   

Rabbit anti-human myosin, heavy chain 10, non-muscle polyclonal Antibody

 Product Synonym Names    myosin; heavy chain 10; non-muscle; MYH10; MGC134913; MGC134914; NMMHCB
 Product Gene Name   

anti-MYH10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    160776
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human MYH10
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47205 / sc-47204
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MYH10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYH10 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for MYH10. It may not necessarily be applicable to this product.
 NCBI GI #    109734615
 NCBI GeneID    4628
 NCBI Accession #    AAI17692.1 [Other Products]
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 UniProt Secondary Accession #    Q12989; Q149N3; Q149N4; Q16087; Q4LE45; Q6PK16; Q9BWG0; B2RWP9; D3DTS1; F8VTL3 [Other Products]
 UniProt Related Accession #    P35580 [Other Products]
 Molecular Weight    230,030 Da [Similar Products]
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 NCBI Official Full Name    Myosin, heavy chain 10, non-muscle
 NCBI Official Synonym Full Names    myosin, heavy chain 10, non-muscle
 NCBI Official Symbol    MYH10 [Similar Products]
 NCBI Official Synonym Symbols   
NMMHCB; NMMHC-IIB
[Similar Products]
 NCBI Protein Information    myosin-10; nonmuscle myosin heavy chain IIB; nonmuscle myosin II heavy chain-B; cellular myosin heavy chain, type B; myosin heavy chain, nonmuscle type B; myosin, heavy polypeptide 10, non-muscle
 UniProt Protein Name    Myosin-10
 UniProt Synonym Protein Names   
Cellular myosin heavy chain, type B; Myosin heavy chain 10; Myosin heavy chain, non-muscle IIb; Non-muscle myosin heavy chain B; NMMHC-B; Non-muscle myosin heavy chain IIb; NMMHC II-b; NMMHC-IIB
 Protein Family    Myosin
 UniProt Gene Name    MYH10 [Similar Products]
 UniProt Synonym Gene Names    NMMHC-B; NMMHC II-b; NMMHC-IIB [Similar Products]
 UniProt Entry Name    MYH10_HUMAN
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 NCBI Summary for MYH10    This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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 UniProt Comments for MYH10    MYH10: Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECM29. Interacts with KIF26B. Interacts with LARP6. Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: mitochondrion; myosin II complex; dendritic spine; actomyosin; cell cortex; actin cytoskeleton; growth cone; cell soma; lamellipodium; axon; cytoplasm; stress fiber; plasma membrane; spindle; midbody; neuromuscular junction; myosin complex; nucleus; cleavage furrow

Molecular Function: calmodulin binding; actin filament binding; microfilament motor activity; protein binding; ADP binding; actin binding; actin-dependent ATPase activity; ATP binding

Biological Process: adult heart development; axon guidance; exocytosis; actin filament-based movement; metabolic process; in utero embryonic development; ventricular cardiac muscle cell development; actomyosin structure organization and biogenesis; fourth ventricle development; neuron migration; cerebellar Purkinje cell layer development; cardiac myofibril assembly; third ventricle development; substrate-bound cell migration, cell extension; cell proliferation; regulation of cell shape; cytokinesis after mitosis; plasma membrane repair; retina development in camera-type eye; ephrin receptor signaling pathway; neuromuscular process controlling balance; cell adhesion; nuclear migration; lateral ventricle development
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 Research Articles on MYH10    1. Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYH10 antibodyPathways associated with anti-MYH10 antibody
 Reference Product  PubMed Publications
 MYH9 antibody  >11 publications with MYH10 and MYH9
 MYL9 antibody  >2 publications with MYH10 and MYL9
 MYL12A antibody  >1 publications with MYH10 and MYL12A
 MYH11 antibody  >1 publications with MYH10 and MYH11
 MYL6 antibody  >1 publications with MYH10 and MYL6
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Salmonella Infection Pathway antibodies  Salmonella Infection Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
Diseases associated with anti-MYH10 antibodyOrgans/Tissues associated with anti-MYH10 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with MYH10 and Nervous System Diseases
 Heart Diseases Antibodies  >2 publications with MYH10 and Heart Diseases
 Cardiovascular Diseases Antibodies  >2 publications with MYH10 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with MYH10 and Kidney Diseases
 Glomerulosclerosis, Focal Segmental Antibodies  >2 publications with MYH10 and Glomerulosclerosis, Focal Segmental
 Hypertension Antibodies  >1 publications with MYH10 and Hypertension
 Atrophy Antibodies  >1 publications with MYH10 and Atrophy
 Atherosclerosis Antibodies  >1 publications with MYH10 and Atherosclerosis
 Disease Models, Animal Antibodies  >1 publications with MYH10 and Disease Models, Animal
 Hyperplasia Antibodies  >1 publications with MYH10 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >12 publications with MYH10 and Muscle
 Brain Antibodies  >8 publications with MYH10 and Brain
 Heart Antibodies  >7 publications with MYH10 and Heart
 Blood Antibodies  >5 publications with MYH10 and Blood
 Lung Antibodies  >3 publications with MYH10 and Lung
 Kidney Antibodies  >2 publications with MYH10 and Kidney
 Vascular Antibodies  >2 publications with MYH10 and Vascular
 Embryonic Tissue Antibodies  >2 publications with MYH10 and Embryonic Tissue
 Prostate Antibodies  >1 publications with MYH10 and Prostate
 Testis Antibodies  >1 publications with MYH10 and Testis
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