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anti-MYH11 antibody :: Rabbit myosin, heavy chain 11, smooth muscle Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719273 anti-MYH11 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

myosin, heavy chain 11, smooth muscle (MYH11), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human myosin, heavy chain 11, smooth muscle polyclonal Antibody

 Product Synonym Names    myosin; heavy chain 11; smooth muscle; MYH11; AAT4; DKFZp686D10126; DKFZp686D19237; FAA4; FLJ35232; MGC126726; MGC32963; SMHC; SMMHC
 Product Gene Name   

anti-MYH11 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    160745
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human MYH11
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-79078 / sc-79079 / sc-98705
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-MYH11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-MYH11 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for MYH11. It may not necessarily be applicable to this product.
 NCBI GI #    219521495
 NCBI GeneID    4629
 NCBI Accession #    AAI43365.1 [Other Products]
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 UniProt Secondary Accession #    O00396; O94944; P78422; Q3MIV8; Q3MNF0; Q3MNF1; D2JYH7 [Other Products]
 UniProt Related Accession #    P35749 [Other Products]
 Molecular Weight    223,577 Da [Similar Products]
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 NCBI Official Full Name    Myosin, heavy chain 11, smooth muscle
 NCBI Official Synonym Full Names    myosin, heavy chain 11, smooth muscle
 NCBI Official Symbol    MYH11 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    myosin-11; myosin heavy chain 11; myosin heavy chain, smooth muscle isoform; myosin, heavy polypeptide 11, smooth muscle
 UniProt Protein Name    Myosin-11
 UniProt Synonym Protein Names   
Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC
 Protein Family    Myosin
 UniProt Gene Name    MYH11 [Similar Products]
 UniProt Synonym Gene Names    KIAA0866 [Similar Products]
 UniProt Entry Name    MYH11_HUMAN
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 NCBI Summary for MYH11    The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript that encodes a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MYH11    MYH11: Muscle contraction. A chromosomal aberration involving MYH11 is found in acute myeloid leukemia of M4EO subtype. Pericentric inversion inv(16)(p13;q22). The inversion produces a fusion protein consisting of the 165 N-terminal residues of CBF-beta (PEPB2) and the tail region of MYH11. Defects in MYH11 are the cause of familial aortic aneurysm thoracic type 4 (AAT4); also known as familial thoracic aortic aneurysm and dissection (TAAD). Aneurysms and dissections of the aorta usually result from degenerative changes in the aortic wall. Thoracic aortic aneurysms and dissections are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. Patients with AAT4 show marked aortic stiffness. Pathological aortas show large areas of medial degeneration with very low smooth muscle cells content. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motor; Oncoprotein; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.11

Cellular Component: smooth muscle contractile fiber; stress fiber; melanosome; muscle myosin complex; cytosol

Molecular Function: actin filament binding; calmodulin binding; protein binding; structural constituent of muscle; motor activity; ATP binding

Biological Process: muscle thick filament assembly; axon guidance; elastic fiber assembly; smooth muscle contraction; muscle contraction; cardiac muscle fiber development; metabolic process; ephrin receptor signaling pathway

Disease: Aortic Aneurysm, Familial Thoracic 4
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 Research Articles on MYH11    1. MYH11 gene mutation is associated with family history of thoracic aortic aneurysm dissection.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MYH11 antibodyPathways associated with anti-MYH11 antibody
 Reference Product  PubMed Publications
 ACTA2 antibody  >27 publications with MYH11 and ACTA2
 MYLK antibody  >7 publications with MYH11 and MYLK
 VCL antibody  >1 publications with MYH11 and VCL
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHA-mediated Growth Cone Collapse Pathway antibodies  EPHA-mediated Growth Cone Collapse Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Sema4D In Semaphorin Signaling Pathway antibodies  Sema4D In Semaphorin Signaling Pathway Diagram
 Sema4D Induced Cell Migration And Growth-cone Collapse Pathway antibodies  Sema4D Induced Cell Migration And Growth-cone Collapse Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
 Smooth Muscle Contraction Pathway antibodies  Smooth Muscle Contraction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
Diseases associated with anti-MYH11 antibodyOrgans/Tissues associated with anti-MYH11 antibody
 Disease Name  Pubmed Publications
 Leukemia, Myeloid, Acute Antibodies  >274 publications with MYH11 and Leukemia, Myeloid, Acute
 Leukemia, Myelomonocytic, Acute Antibodies  >53 publications with MYH11 and Leukemia, Myelomonocytic, Acute
 Cell Transformation, Neoplastic Antibodies  >9 publications with MYH11 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >8 publications with MYH11 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >6 publications with MYH11 and Neoplasms, Experimental
 Skin Diseases Antibodies  >6 publications with MYH11 and Skin Diseases
 Atherosclerosis Antibodies  >4 publications with MYH11 and Atherosclerosis
 Hyperplasia Antibodies  >4 publications with MYH11 and Hyperplasia
 Inflammation Antibodies  >3 publications with MYH11 and Inflammation
 Carcinoma Antibodies  >2 publications with MYH11 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >121 publications with MYH11 and Blood
 Bone Marrow Antibodies  >107 publications with MYH11 and Bone Marrow
 Muscle Antibodies  >75 publications with MYH11 and Muscle
 Vascular Antibodies  >26 publications with MYH11 and Vascular
 Heart Antibodies  >9 publications with MYH11 and Heart
 Intestine Antibodies  >6 publications with MYH11 and Intestine
 Testis Antibodies  >5 publications with MYH11 and Testis
 Lymph Antibodies  >5 publications with MYH11 and Lymph
 Lymph Node Antibodies  >5 publications with MYH11 and Lymph Node
 Nerve Antibodies  >4 publications with MYH11 and Nerve
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