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anti-n-NOS antibody :: Rabbit n-NOS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS859762
Unit / Price
0.1 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

n-NOS, Polyclonal Antibody

★Popular Item★
 Also Known As   

n-NOS (Phospho-Ser852) Antibody

 Product Synonym Names    BNOS; Constitutive NOS; EC 1.14.13.39; N-NOS; NC-NOS; NOS; type I; NOS1; Neuronal NOS; Nitric-oxide synthase; brain; bNOS
 Product Gene Name   

anti-n-NOS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    163731
 3D Structure    ModBase 3D Structure for P29476
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    n-NOS (Phospho-Ser852) antibody detects endogenous levels of n-NOS only when phosphorylated at serine 847.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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 Immunogen    The antiserum was produced against synthesized phosphopeptide derived from human n-NOS around the phosphorylation site of serine 847 (F-N-SP-V-S).
 All Sites    Human: Ser852; Mouse: Ser847; Rat: Ser847
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-n-NOS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-n-NOS antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-n-NOS antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA (EIA)

 Application Notes for anti-n-NOS antibody    WB: 1:500~1:1000, IHC: 1:50~1:100, IF: 1:100~1:500, ELISA: 1:1000
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 Testing Data of anti-n-NOS antibody    P-peptide - +
anti-n-NOS antibody Testing Data image
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 Testing Data #2 of anti-n-NOS antibody    Immunohistochemistry analysis of paraffin-embedded human brain tissue using n-NOS (Phospho-Ser852) antibody.
Western blot analysis of extracts from A549 cells, using n-NOS (Phospho-Ser852) antibody.
anti-n-NOS antibody Testing Data #2 image
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 Testing Data #3 of anti-n-NOS antibody    P-peptide - +
Immunofluorescence analysis of HeLa cells, using n-NOS (Phospho-Ser852) antibody.
anti-n-NOS antibody Testing Data #3 image
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NCBI/Uniprot data below describe general gene information for n-NOS. It may not necessarily be applicable to this product.
 NCBI GI #    10835173
 NCBI GeneID    4842
 NCBI Accession #    NP_000611.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000620.4 [Other Products]
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 UniProt Primary Accession #    P29476 [Other Products]
 UniProt Secondary Accession #    O75713; E9PH30 [Other Products]
 UniProt Related Accession #    P29475 [Other Products]
 Molecular Weight    164,779 Da
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 NCBI Official Full Name    nitric oxide synthase, brain isoform 1
 NCBI Official Synonym Full Names    nitric oxide synthase 1 (neuronal)
 NCBI Official Symbol    NOS1 [Similar Products]
 NCBI Official Synonym Symbols   
NOS; bNOS; nNOS; IHPS1; N-NOS; NC-NOS
[Similar Products]
 NCBI Protein Information    nitric oxide synthase, brain; NOS type I; neuronal NOS; constitutive NOS; peptidyl-cysteine S-nitrosylase NOS1
 UniProt Protein Name    Nitric oxide synthase, brain
 UniProt Synonym Protein Names   
Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS; N-NOS; nNOS; Peptidyl-cysteine S-nitrosylase NOS1; bNOS
 UniProt Gene Name    NOS1 [Similar Products]
 UniProt Synonym Gene Names    N-NOS; nNOS [Similar Products]
 UniProt Entry Name    NOS1_HUMAN
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 NCBI Summary for n-NOS    The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]
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 UniProt Comments for n-NOS    nNOS: nitric oxide synthase 1, neuronal form. Produces nitric oxide which is a messenger molecule with diverse functions and displays many properties of a neurotransmitter in the brain and peripheral nervous system. May be an effector enzyme for the dystrophin complex. Four alternatively spliced isoforms have been described.

Protein type: Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.14.13.39

Chromosomal Location of Human Ortholog: 12q24.22

Cellular Component: photoreceptor inner segment; cytoskeleton; protein complex; mitochondrion; sarcoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm; dendritic spine; synapse; cytosol; sarcolemma; lipid raft

Molecular Function: calmodulin binding; protein binding; sodium channel regulator activity; FAD binding; NADPH-hemoprotein reductase activity; nitric-oxide synthase activity; FMN binding; iron ion binding; heme binding; oxidoreductase activity; NADP binding; cadmium ion binding

Biological Process: negative regulation of serotonin uptake; interaction with host; negative regulation of calcium ion transport; striated muscle contraction; negative regulation of potassium ion transport; positive regulation of transcription, DNA-dependent; positive regulation of guanylate cyclase activity; regulation of sodium ion transport; positive regulation of vasodilation; response to heat; negative regulation of hydrolase activity; exogenous drug catabolic process; peptidyl-cysteine S-nitrosylation; response to hypoxia; arginine catabolic process; positive regulation of histone acetylation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of blood pressure; nitric oxide biosynthetic process; blood coagulation; nitric oxide mediated signal transduction; multicellular organismal response to stress; myoblast fusion; neurotransmitter biosynthetic process

Disease: Pyloric Stenosis, Infantile Hypertrophic, 1
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Product References and Citations for anti-n-NOS antibody

   George D. Webb, J. Thorac. Cardiovasc. Surg., Nov 2006; 132: 1131 - 1136.
Montserrat Garc-a -Vitoria, J. Histochem. Cytochem., Aug 2000; 48: 1111.
Peter J. Reiser, J Appl Physiol, Apr 1997; 82: 1250.
VL Dawson, J. Neurosci., Apr 1996; 16: 2479.
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 Research Articles on n-NOS    1. The resukts of this study demonistrated that the risk allele significantly decreases expression of NOS1 in the prefrontal cortex in patient with schizophrenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-n-NOS antibodyPathways associated with anti-n-NOS antibody
 Reference Product  PubMed Publications
 CAV3 antibody  >7 publications with n-NOS and CAV3
 ARG1 antibody  >6 publications with n-NOS and ARG1
 UBC antibody  >3 publications with n-NOS and UBC
 DLG4 antibody  >2 publications with n-NOS and DLG4
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies  Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-n-NOS antibodyOrgans/Tissues associated with anti-n-NOS antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >493 publications with n-NOS and Nervous System Diseases
 Brain Diseases Antibodies  >261 publications with n-NOS and Brain Diseases
 Disease Models, Animal Antibodies  >232 publications with n-NOS and Disease Models, Animal
 Hypertension Antibodies  >160 publications with n-NOS and Hypertension
 Mental Disorders Antibodies  >154 publications with n-NOS and Mental Disorders
 Inflammation Antibodies  >130 publications with n-NOS and Inflammation
 Brain Ischemia Antibodies  >105 publications with n-NOS and Brain Ischemia
 Heart Diseases Antibodies  >95 publications with n-NOS and Heart Diseases
 Pain Antibodies  >92 publications with n-NOS and Pain
 Kidney Diseases Antibodies  >60 publications with n-NOS and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1103 publications with n-NOS and Brain
 Muscle Antibodies  >484 publications with n-NOS and Muscle
 Kidney Antibodies  >213 publications with n-NOS and Kidney
 Lung Antibodies  >79 publications with n-NOS and Lung
 Uterus Antibodies  >15 publications with n-NOS and Uterus
 Ovary Antibodies  >13 publications with n-NOS and Ovary
 Prostate Antibodies  >7 publications with n-NOS and Prostate
 Uncharacterized Tissue Antibodies  >3 publications with n-NOS and Uncharacterized Tissue
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