AAN06814.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
nephronophthisis 4
NCBI Official Synonym Full Names
nephronophthisis 4
NCBI Official Synonym Symbols
NCBI Protein Information
nephrocystin-4; nephroretinin; POC10 centriolar protein homolog
UniProt Protein Name
Nephrocystin-4
UniProt Synonym Protein Names
Nephroretinin
UniProt Synonym Gene Names
UniProt Entry Name
NPHP4_HUMAN
NCBI Summary for NPHP4
This gene encodes a protein involved in renal tubular development and function. This protein interacts with nephrocystin, and belongs to a multifunctional complex that is localized to actin- and microtubule-based structures. Mutations in this gene are associated with nephronophthisis type 4, a renal disease, and with Senior-Loken syndrome type 4, a combination of nephronophthisis and retinitis pigmentosa. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
UniProt Comments for NPHP4
NPHP4: Involved in the organization of apical junctions in kidney cells together with NPHP1 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in NPHP4 are the cause of nephronophthisis type 4 (NPHP4); also known as familial juvenile nephronophthisis 4. NPHP4 is an autosomal recessive inherited disease resulting in end-stage renal disease at age ranging between 6 and 35 years. It is a progressive tubulo-interstitial kidney disorder characterized by polydipsia, polyuria, anemia and growth retardation. The most prominent histological features are modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Ciliary dysfunction leads to a broad spectrum of disorders, collectively termed ciliopathies. Overlapping clinical features include retinal degeneration, renal cystic disease, skeletal abnormalities, fibrosis of various organ, and a complex range of anatomical and functional defects of the central and peripheral nervous system. The ciliopathy range of diseases includes Meckel-Gruber syndrome, Bardet-Biedl syndrome, Joubert syndrome, nephronophtisis, Senior-Loken syndrome, and Jeune asphyxiating thoracic dystrophy among others. Single-locus allelism is insufficient to explain the variable penetrance and expressivity of such disorders, leading to the suggestion that variations across multiple sites of the ciliary proteome, including NPHP4, influence the clinical outcome. Defects in NPHP4 are the cause of Senior-Loken syndrome type 4 (SLSN4). SLSN is a renal-retinal disorder characterized by progressive wasting of the filtering unit of the kidney, with or without medullary cystic renal disease, and progressive eye disease. Typically this disorder becomes apparent during the first year of life. Belongs to the NPHP4 family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: centrosome; tight junction; membrane; intercellular junction; cytosol; photoreceptor connecting cilium
Molecular Function: protein binding; structural molecule activity
Biological Process: cell-cell adhesion; sperm motility; retina development in camera-type eye; organelle organization and biogenesis; photoreceptor cell maintenance; actin cytoskeleton organization and biogenesis; signal transduction; visual behavior
Disease: Nephronophthisis 4; Senior-loken Syndrome 4
Research Articles on NPHP4
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Products associated with anti-NPHP4 antibody
Pathways associated with anti-NPHP4 antibody
Diseases associated with anti-NPHP4 antibody
Organs/Tissues associated with anti-NPHP4 antibody
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