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anti-NPHS2 antibody :: Rabbit nephrosis 2, idiopathic, steroid-resistant Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712021 anti-NPHS2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nephrosis 2, idiopathic, steroid-resistant (NPHS2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human nephrosis 2, idiopathic, steroid-resistant (podocin) polyclonal Antibody

 Product Synonym Names    nephrosis 2; idiopathic; steroid-resistant (podocin); NPHS2; PDCN; SRN1
 Product Gene Name   

anti-NPHS2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    604766
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human NPHS2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22296 / sc-22294 / sc-21009
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NPHS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NPHS2 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for NPHS2. It may not necessarily be applicable to this product.
 NCBI GI #    119611455
 NCBI GeneID    7827
 NCBI Accession #    EAW91049.1 [Other Products]
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 UniProt Secondary Accession #    Q8N6Q5; B1AM32; B1AM33 [Other Products]
 UniProt Related Accession #    Q9NP85 [Other Products]
 Molecular Weight    34,421 Da [Similar Products]
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 NCBI Official Full Name    nephrosis 2, idiopathic, steroid-resistant (podocin), isoform CRA_a
 NCBI Official Synonym Full Names    nephrosis 2, idiopathic, steroid-resistant (podocin)
 NCBI Official Symbol    NPHS2 [Similar Products]
 NCBI Official Synonym Symbols   
PDCN; SRN1
[Similar Products]
 NCBI Protein Information    podocin
 UniProt Protein Name    Podocin
 Protein Family    Podocin
 UniProt Gene Name    NPHS2 [Similar Products]
 UniProt Entry Name    PODO_HUMAN
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 NCBI Summary for NPHS2    This gene encodes a protein that plays a role in the regulation of glomerular permeability. Mutations in this gene cause steroid-resistant nephrotic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
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 UniProt Comments for NPHS2    NPHS2: Plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. Defects in NPHS2 are the cause of nephrotic syndrome type 2 (NPHS2). It is a renal disorder characterized clinically by childhood onset of proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Kidney biopsies show non-specific histologic changes such as focal segmental glomerulosclerosis and diffuse mesangial proliferation. The disorder is resistant to steroid treatment and progresses to end-stage renal failure in the first or second decades. Some patients show later onset of the disorder. Belongs to the band 7/mec-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q25.2

Cellular Component: protein complex; integral to plasma membrane; endoplasmic reticulum; plasma membrane; intercellular junction; lipid raft

Molecular Function: protein binding

Biological Process: actin cytoskeleton reorganization; excretion

Disease: Nephrotic Syndrome, Type 2
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 Research Articles on NPHS2    1. Case Report: novel NPHS2 sequence variant in a girl with steroid-resistant nephrotic syndrome and focal and segmental glomerulosclerosis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NPHS2 antibodyPathways associated with anti-NPHS2 antibody
 Reference Product  PubMed Publications
 CD2AP antibody  >61 publications with NPHS2 and CD2AP
 TRPC6 antibody  >29 publications with NPHS2 and TRPC6
 KIRREL antibody  >8 publications with NPHS2 and KIRREL
 FYN antibody  >2 publications with NPHS2 and FYN
 KIRREL3 antibody  >1 publications with NPHS2 and KIRREL3
 GRB2 antibody  >1 publications with NPHS2 and GRB2
 Products by Pathway  Pathway Diagram
 Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway antibodies  Nephrin/Neph1 Signaling In The Kidney Podocyte Pathway Diagram
Diseases associated with anti-NPHS2 antibodyOrgans/Tissues associated with anti-NPHS2 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >369 publications with NPHS2 and Kidney Diseases
 Nephrotic Syndrome Antibodies  >248 publications with NPHS2 and Nephrotic Syndrome
 Proteinuria Antibodies  >234 publications with NPHS2 and Proteinuria
 Nephrosis Antibodies  >215 publications with NPHS2 and Nephrosis
 Glomerulosclerosis, Focal Segmental Antibodies  >141 publications with NPHS2 and Glomerulosclerosis, Focal Segmental
 Glomerulonephritis Antibodies  >139 publications with NPHS2 and Glomerulonephritis
 Renal Insufficiency Antibodies  >51 publications with NPHS2 and Renal Insufficiency
 Albuminuria Antibodies  >49 publications with NPHS2 and Albuminuria
 Kidney Failure, Chronic Antibodies  >42 publications with NPHS2 and Kidney Failure, Chronic
 Hypertension Antibodies  >23 publications with NPHS2 and Hypertension
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >379 publications with NPHS2 and Kidney
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