NP_571516.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
262,308 Da
NCBI Official Full Name
neurogenic locus notch homolog protein 1
NCBI Official Synonym Full Names
notch 1a
NCBI Official Synonym Symbols
des; n1a; wu:fc01e02; wu:fc37a05 [Similar Products]
NCBI Protein Information
neurogenic locus notch homolog protein 1
UniProt Protein Name
Neurogenic locus notch homolog protein 1
UniProt Synonym Gene Names
UniProt Comments for notch1a
Functions as a receptor for membrane-bound ligands jagged1, jagged2 and delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis (). Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO) ().
Research Articles on notch1a
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Pathways associated with anti-notch1a antibody
Diseases associated with anti-notch1a antibody
Organs/Tissues associated with anti-notch1a antibody
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