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anti-NUMA1 antibody :: Rabbit nuclear mitotic apparatus protein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS719074 anti-NUMA1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nuclear mitotic apparatus protein 1 (NUMA1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human nuclear mitotic apparatus protein 1 polyclonal Antibody

 Product Synonym Names    nuclear mitotic apparatus protein 1; NUMA1; NUMA
 Product Gene Name   

anti-NUMA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    164009
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human NUMA1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-18555 / sc-18557 / sc-48773
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NUMA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NUMA1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for NUMA1. It may not necessarily be applicable to this product.
 NCBI GI #    145559510
 NCBI GeneID    4926
 NCBI Accession #    Q14980.2 [Other Products]
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 UniProt Secondary Accession #    Q14981; Q9BTE9; H0YH75 [Other Products]
 UniProt Related Accession #    Q14980 [Other Products]
 Molecular Weight    109,279 Da [Similar Products]
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 NCBI Official Full Name    Nuclear mitotic apparatus protein 1
 NCBI Official Synonym Full Names    nuclear mitotic apparatus protein 1
 NCBI Official Symbol    NUMA1 [Similar Products]
 NCBI Official Synonym Symbols   
NUMA
[Similar Products]
 NCBI Protein Information    nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells
 UniProt Protein Name    Nuclear mitotic apparatus protein 1
 UniProt Synonym Protein Names   
Nuclear matrix protein-22
 Protein Family    Nuclear mitotic apparatus protein
 UniProt Gene Name    NUMA1 [Similar Products]
 UniProt Synonym Gene Names    NMP-22 [Similar Products]
 UniProt Entry Name    NUMA1_HUMAN
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 NCBI Summary for NUMA1    This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
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 UniProt Comments for NUMA1    NuMA-1: a coiled-coil nuclear protein that is required to establish and maintain mammalian spindle poles. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. Two human splice-variant isoforms have been described.

Protein type: Cell cycle regulation; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: spindle pole; nuclear matrix; dendrite; chromosome; cytosol; nucleoplasm; Golgi membrane; cell soma; apical part of cell; spindle microtubule; cytoplasm; spindle; nucleus

Molecular Function: protein binding; microtubule binding; structural molecule activity

Biological Process: mitosis; meiotic cell cycle; establishment of mitotic spindle orientation; cell division; mitotic cell cycle; G2/M transition of mitotic cell cycle; nuclear organization and biogenesis

Disease: Acute Promyelocytic Leukemia
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 Research Articles on NUMA1    1. NuMA interacts with phosphoinositides and links the mitotic spindle with the plasma membrane.During anaphase correct NuMA localization is mediated by direct membrane phospholipid binding.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NUMA1 antibodyPathways associated with anti-NUMA1 antibody
 Reference Product  PubMed Publications
 CASP3 antibody  >8 publications with NUMA1 and CASP3
 CDK1 antibody  >5 publications with NUMA1 and CDK1
 CASP6 antibody  >2 publications with NUMA1 and CASP6
 EPB41L1 antibody  >2 publications with NUMA1 and EPB41L1
 YEATS4 antibody  >2 publications with NUMA1 and YEATS4
 CCNB1 antibody  >1 publications with NUMA1 and CCNB1
 DCTN1 antibody  >1 publications with NUMA1 and DCTN1
 NEDD1 antibody  >1 publications with NUMA1 and NEDD1
 Products by Pathway  Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Recruitment Of NuMA To Mitotic Centrosomes Pathway antibodies  Recruitment Of NuMA To Mitotic Centrosomes Pathway Diagram
 Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway antibodies  Recruitment Of Mitotic Centrosome Proteins And Complexes Pathway Diagram
Diseases associated with anti-NUMA1 antibodyOrgans/Tissues associated with anti-NUMA1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >11 publications with NUMA1 and Breast Neoplasms
 Nervous System Diseases Antibodies  >7 publications with NUMA1 and Nervous System Diseases
 Prostatic Neoplasms Antibodies  >4 publications with NUMA1 and Prostatic Neoplasms
 Prostatic Diseases Antibodies  >4 publications with NUMA1 and Prostatic Diseases
 Adenocarcinoma Antibodies  >4 publications with NUMA1 and Adenocarcinoma
 Brain Diseases Antibodies  >4 publications with NUMA1 and Brain Diseases
 Lung Diseases Antibodies  >3 publications with NUMA1 and Lung Diseases
 Ovarian Diseases Antibodies  >2 publications with NUMA1 and Ovarian Diseases
 Ovarian Neoplasms Antibodies  >2 publications with NUMA1 and Ovarian Neoplasms
 Liver Neoplasms Antibodies  >1 publications with NUMA1 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >20 publications with NUMA1 and Blood
 Nerve Antibodies  >11 publications with NUMA1 and Nerve
 Bone Antibodies  >8 publications with NUMA1 and Bone
 Lung Antibodies  >7 publications with NUMA1 and Lung
 Brain Antibodies  >7 publications with NUMA1 and Brain
 Skin Antibodies  >6 publications with NUMA1 and Skin
 Connective Tissue Antibodies  >6 publications with NUMA1 and Connective Tissue
 Bone Marrow Antibodies  >6 publications with NUMA1 and Bone Marrow
 Kidney Antibodies  >6 publications with NUMA1 and Kidney
 Muscle Antibodies  >4 publications with NUMA1 and Muscle
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