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anti-NDE1 antibody :: Rabbit nudE nuclear distribution gene E homolog 1 (A. nidulans) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710201 anti-NDE1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

nudE nuclear distribution gene E homolog 1 (A. nidulans) (NDE1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human nudE nuclear distribution gene E homolog 1 (A. nidulans) polyclonal Antibody

 Product Synonym Names    nudE nuclear distribution gene E homolog 1 (A. nidulans); NDE1; FLJ20101; HOM-TES-87; NUDE; NUDE1
 Product Gene Name   

anti-NDE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614019
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human NDE1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NDE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NDE1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for NDE1. It may not necessarily be applicable to this product.
 NCBI GI #    12655137
 NCBI GeneID    54820
 NCBI Accession #    AAH01421.1 [Other Products]
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 UniProt Secondary Accession #    Q49AQ2 [Other Products]
 UniProt Related Accession #    Q9NXR1 [Other Products]
 Molecular Weight    37,721 Da [Similar Products]
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 NCBI Official Full Name    NudE nuclear distribution gene E homolog 1 (A. nidulans)
 NCBI Official Synonym Full Names    nudE neurodevelopment protein 1
 NCBI Official Symbol    NDE1 [Similar Products]
 NCBI Official Synonym Symbols   
NDE; LIS4; MHAC; NUDE; NUDE1; HOM-TES-87
[Similar Products]
 NCBI Protein Information    nuclear distribution protein nudE homolog 1; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; LIS1-interacting protein NUDE1, rat homolog
 UniProt Protein Name    Nuclear distribution protein nudE homolog 1
 Protein Family    Nuclear distribution protein
 UniProt Gene Name    NDE1 [Similar Products]
 UniProt Synonym Gene Names    NUDE; NudE [Similar Products]
 UniProt Entry Name    NDE1_HUMAN
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 NCBI Summary for NDE1    This gene encodes a member of the nuclear distribution E (NudE) family of proteins. The encoded protein is localized at the centrosome and interacts with other centrosome components as part of a multiprotein complex that regulates dynein function. This protein plays an essential role in microtubule organization, mitosis and neuronal migration. Mutations in this gene cause lissencephaly 4, a disorder characterized by lissencephaly, severe brain atrophy, microcephaly, and severe mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
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 UniProt Comments for NDE1    NUDE1: a microtubule-associated protein required for centrosome duplication, and the formation and function of the mitotic spindle. Associated with the centrosome, kinetochore, and spindle. Specifically phosphorylated during M phase, inducing its association with mitotic spindles. Appears to participate in dynein-mediated transport of kinetochore proteins to spindle poles along microtubules. Interacts with gamma tubulin, dynactin, CEP110, dynein,TCP1. PAFAH1B1, PCM-1 and PCNT. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase, and at the cleavage furrow during cytokinesis.Two alternatively spliced human isoforms have been described.

Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding

Chromosomal Location of Human Ortholog: 16p13.11

Cellular Component: kinetochore; microtubule; kinesin complex; centrosome; membrane; spindle pole centrosome; cytosol; cleavage furrow

Molecular Function: protein domain specific binding; identical protein binding; protein binding; microtubule binding

Biological Process: cell migration; organelle organization and biogenesis; neuron migration; establishment of chromosome localization; microtubule nucleation; chromosome segregation; mitotic centrosome separation; establishment of mitotic spindle orientation; centrosome localization; cell division; neuroblast proliferation; vesicle transport along microtubule; cerebral cortex development; mitotic cell cycle; G2/M transition of mitotic cell cycle; centrosome duplication

Disease: Lissencephaly 4; Microhydranencephaly
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 Research Articles on NDE1    1. Description of a severe microcephaly syndrome where an autosomal recessive condition combines an inherited segmental duplication mediated deletion with a mutation in the NDE1 gene within the non-deleted homolog.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NDE1 antibodyPathways associated with anti-NDE1 antibody
 Reference Product  PubMed Publications
 PAFAH1B1 antibody  >15 publications with NDE1 and PAFAH1B1
 CDK1 antibody  >1 publications with NDE1 and CDK1
 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Centrosome Maturation Pathway antibodies  Centrosome Maturation Pathway Diagram
 G2/M Transition Pathway antibodies  G2/M Transition Pathway Diagram
 Loss Of Nlp From Mitotic Centrosomes Pathway antibodies  Loss Of Nlp From Mitotic Centrosomes Pathway Diagram
 Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway antibodies  Loss Of Proteins Required For Interphase Microtubule Organization From The Centrosome Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic Anaphase Pathway antibodies  Mitotic Anaphase Pathway Diagram
 Mitotic G2-G2/M Phases Pathway antibodies  Mitotic G2-G2/M Phases Pathway Diagram
 Mitotic Metaphase And Anaphase Pathway antibodies  Mitotic Metaphase And Anaphase Pathway Diagram
Diseases associated with anti-NDE1 antibodyOrgans/Tissues associated with anti-NDE1 antibody
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >12 publications with NDE1 and Congenital Abnormalities
 Disease Models, Animal Antibodies  >4 publications with NDE1 and Disease Models, Animal
 Seizures Antibodies  >2 publications with NDE1 and Seizures
 Heart Diseases Antibodies  >1 publications with NDE1 and Heart Diseases
 Breast Neoplasms Antibodies  >1 publications with NDE1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with NDE1 and Kidney Diseases
 Liver Neoplasms Antibodies  >1 publications with NDE1 and Liver Neoplasms
 Liver Diseases Antibodies  >1 publications with NDE1 and Liver Diseases
 Kidney Neoplasms Antibodies  >1 publications with NDE1 and Kidney Neoplasms
 Carcinoma Antibodies  >1 publications with NDE1 and Carcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with NDE1 and Brain
 Nerve Antibodies  >17 publications with NDE1 and Nerve
 Eye Antibodies  >2 publications with NDE1 and Eye
 Spinal Cord Antibodies  >1 publications with NDE1 and Spinal Cord
 Embryonic Tissue Antibodies  >1 publications with NDE1 and Embryonic Tissue
 Liver Antibodies  >1 publications with NDE1 and Liver
 Heart Antibodies  >1 publications with NDE1 and Heart
 Kidney Antibodies  >1 publications with NDE1 and Kidney
 Prostate Antibodies  >1 publications with NDE1 and Prostate
 Skin Antibodies  >1 publications with NDE1 and Skin
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