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anti-OCRL antibody :: Rabbit oculocerebrorenal syndrome of Lowe Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716943 anti-OCRL antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

oculocerebrorenal syndrome of Lowe (OCRL), Polyclonal Antibody

 Also Known As   

Rabbit anti-human oculocerebrorenal syndrome of Lowe polyclonal Antibody

 Product Synonym Names    oculocerebrorenal syndrome of Lowe; OCRL; INPP5F; LOCR; NPHL2; OCRL1
 Product Gene Name   

anti-OCRL antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    309000
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human OCRL
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12088 / sc-12090 / sc-12087 / sc-12089
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-OCRL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-OCRL antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for OCRL. It may not necessarily be applicable to this product.
 NCBI GI #    219518136
 NCBI GeneID    4952
 NCBI Accession #    AAI44107.1 [Other Products]
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 UniProt Secondary Accession #    O60800; Q15684; Q15774; Q4VY09; Q4VY10; Q5JQF1; Q5JQF2; Q9UJG5; A6NKI1; A8KAP2; B7ZLX2 [Other Products]
 UniProt Related Accession #    Q01968 [Other Products]
 Molecular Weight    103,227 Da [Similar Products]
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 NCBI Official Full Name    Oculocerebrorenal syndrome of Lowe
 NCBI Official Synonym Full Names    oculocerebrorenal syndrome of Lowe
 NCBI Official Symbol    OCRL [Similar Products]
 NCBI Official Synonym Symbols   
LOCR; NPHL2; OCRL1; INPP5F; OCRL-1
[Similar Products]
 NCBI Protein Information    inositol polyphosphate 5-phosphatase OCRL-1; Lowe oculocerebrorenal syndrome protein; phosphatidylinositol polyphosphate 5-phosphatase
 UniProt Protein Name    Inositol polyphosphate 5-phosphatase OCRL-1
 UniProt Synonym Protein Names   
Lowe oculocerebrorenal syndrome protein
 Protein Family    Inositol polyphosphate 5-phosphatase
 UniProt Gene Name    OCRL [Similar Products]
 UniProt Synonym Gene Names    INPP5F; OCRL1 [Similar Products]
 UniProt Entry Name    OCRL_HUMAN
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 NCBI Summary for OCRL    This gene encodes a phosphatase enzyme that is involved in actin polymerization and is found in the trans-Golgi network. Mutations in this gene cause oculocerebrorenal syndrome of Lowe and also Dent disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for OCRL    OCRL: Converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Also converts inositol 1,4,5- trisphosphate to inositol 1,4-bisphosphate and inositol 1,3,4,5- tetrakisphosphate to inositol 1,3,4-trisphosphate. May function in lysosomal membrane trafficking by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with lysosomes. Belongs to the inositol-1,4,5-trisphosphate 5- phosphatase type II family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.36; Carbohydrate Metabolism - inositol phosphate; Motility/polarity/chemotaxis; Phosphatase (non-protein)

Chromosomal Location of Human Ortholog: Xq25

Cellular Component: phagocytic vesicle membrane; Golgi stack; photoreceptor outer segment; clathrin-coated vesicle; early endosome membrane; cytoplasm; early endosome; plasma membrane; Golgi-associated vesicle; coated pit; trans-Golgi network; nucleus; cytosol

Molecular Function: protein binding; phosphoinositide 5-phosphatase activity; Rac GTPase binding

Biological Process: regulation of small GTPase mediated signal transduction; inositol phosphate metabolic process; in utero embryonic development; small GTPase mediated signal transduction; phospholipid metabolic process; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; cilium biogenesis; lipid metabolic process

Disease: Lowe Oculocerebrorenal Syndrome; Dent Disease 2
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 Research Articles on OCRL    1. Dent disease is caused by mutations in at least two genes, i.e. CLCN5 and OCRL1, and its genetic background and phenotypes are common among European countries and the USA.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-OCRL antibodyDiseases associated with anti-OCRL antibody
 Products by Pathway  Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies  1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies  D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway antibodies  D-myo-inositol (1,4,5)-trisphosphate Degradation Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 Disease Name  Pubmed Publications
 Oculocerebrorenal Syndrome Antibodies  >142 publications with OCRL and Oculocerebrorenal Syndrome
 Kidney Diseases Antibodies  >131 publications with OCRL and Kidney Diseases
 Nervous System Diseases Antibodies  >121 publications with OCRL and Nervous System Diseases
 Proteinuria Antibodies  >23 publications with OCRL and Proteinuria
 Dent Disease 2 Antibodies  >7 publications with OCRL and Dent Disease 2
 Disease Models, Animal Antibodies  >6 publications with OCRL and Disease Models, Animal
 Developmental Disabilities Antibodies  >4 publications with OCRL and Developmental Disabilities
 Dent disease 1 Antibodies  >4 publications with OCRL and Dent disease 1
 Weight Loss Antibodies  >3 publications with OCRL and Weight Loss
 Insulin Resistance Antibodies  >2 publications with OCRL and Insulin Resistance
Organs/Tissues associated with anti-OCRL antibody
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >45 publications with OCRL and Kidney
 Brain Antibodies  >18 publications with OCRL and Brain
 Eye Antibodies  >14 publications with OCRL and Eye
 Muscle Antibodies  >8 publications with OCRL and Muscle
 Bone Antibodies  >7 publications with OCRL and Bone
 Skin Antibodies  >6 publications with OCRL and Skin
 Intestine Antibodies  >2 publications with OCRL and Intestine
 Embryonic Tissue Antibodies  >2 publications with OCRL and Embryonic Tissue
 Testis Antibodies  >2 publications with OCRL and Testis
 Placenta Antibodies  >1 publications with OCRL and Placenta
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