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anti-NABP2 antibody :: Rabbit oligonucleotide/oligosaccharide-binding fold containing 2B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710629 anti-NABP2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

oligonucleotide/oligosaccharide-binding fold containing 2B (NABP2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human oligonucleotide/oligosaccharide-binding fold containing 2B polyclonal Antibody

 Product Synonym Names    oligonucleotide/oligosaccharide-binding fold containing 2B; OBFC2B; MGC2731; SSB1
 Product Gene Name   

anti-NABP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    612104
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human OBFC2B
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-168826
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-NABP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-NABP2 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for NABP2. It may not necessarily be applicable to this product.
 NCBI GI #    12654499
 NCBI GeneID    79035
 NCBI Accession #    AAH01079.1 [Other Products]
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 UniProt Secondary Accession #    Q6XYC8; A6NDF8 [Other Products]
 UniProt Related Accession #    Q9BQ15 [Other Products]
 Molecular Weight    11,493 Da [Similar Products]
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 NCBI Official Full Name    Oligonucleotide/oligosaccharide-binding fold containing 2B
 NCBI Official Synonym Full Names    nucleic acid binding protein 2
 NCBI Official Symbol    NABP2 [Similar Products]
 NCBI Official Synonym Symbols   
SSB1; hSSB1; OBFC2B; SOSS-B1
[Similar Products]
 NCBI Protein Information    SOSS complex subunit B1; LP3587; sensor of ssDNA subunit B1; nucleic acid-binding protein 2; single strand DNA-binding protein 1; single-stranded DNA-binding protein 1; sensor of single-strand DNA complex subunit B1; oligonucleotide/oligosaccharide-binding fold containing 2B; oligonucleotide/oligosaccharide-binding fold-containing protein 2B
 UniProt Protein Name    SOSS complex subunit B1
 UniProt Synonym Protein Names   
Nucleic acid-binding protein 2; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; SOSS-B1; Single-stranded DNA-binding protein 1; hSSB1
 Protein Family    SOSS complex
 UniProt Gene Name    NABP2 [Similar Products]
 UniProt Synonym Gene Names    OBFC2B; SSB1; SOSS-B1; hSSB1 [Similar Products]
 UniProt Entry Name    SOSB1_HUMAN
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 NCBI Summary for NABP2    Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
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 UniProt Comments for NABP2    OBFC2B: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. Component of the SOSS complex, composed of SOSS-B (SOSS- B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Directly interacts with ATM, SOSS-A/INTS3 and RAD51. Interacts with INTS7. Belongs to the SOSS-B family. SOSS-B1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA repair, damage; Cell cycle regulation

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; single-stranded DNA binding

Biological Process: mitotic cell cycle checkpoint; response to ionizing radiation; DNA repair; response to DNA damage stimulus; double-strand break repair via homologous recombination
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 Research Articles on NABP2    1. The findings demonstrate the importance of hSSB1 in maintaining and repairing DNA replication forks and for overall genomic stability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NABP2 antibodyOrgans/Tissues associated with anti-NABP2 antibody
 Reference Product  PubMed Publications
 RAD51 antibody  >1 publications with NABP2 and RAD51
 ATM antibody  >1 publications with NABP2 and ATM
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1 publications with NABP2 and Blood
 Thyroid Antibodies  >1 publications with NABP2 and Thyroid
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