NP_004757.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
99,046 Da
NCBI Official Full Name
coatomer subunit beta'
NCBI Official Synonym Full Names
coatomer protein complex subunit beta 2
NCBI Official Synonym Symbols
NCBI Protein Information
coatomer subunit beta'
UniProt Protein Name
Coatomer subunit beta'
UniProt Synonym Protein Names
Beta'-coat protein; Beta'-COP; p102
UniProt Synonym Gene Names
UniProt Entry Name
COPB2_HUMAN
NCBI Summary for COPB2
The Golgi coatomer complex (see MIM 601924) constitutes the coat of nonclathrin-coated vesicles and is essential for Golgi budding and vesicular trafficking. It consists of 7 protein subunits, including COPB2.[supplied by OMIM, Jul 2002]
UniProt Comments for COPB2
COPB2: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Belongs to the WD repeat COPB2 family.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 3q23
Cellular Component: COPI vesicle coat; cytosol; endoplasmic reticulum membrane; Golgi membrane; transport vesicle
Molecular Function: protein binding; structural molecule activity
Biological Process: ER to Golgi vesicle-mediated transport; intra-Golgi vesicle-mediated transport; intracellular protein transport; retrograde vesicle-mediated transport, Golgi to ER
Research Articles on COPB2
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Pathways associated with anti-COPB2 antibody
Diseases associated with anti-COPB2 antibody
Organs/Tissues associated with anti-COPB2 antibody
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