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anti-RPS6KB1 antibody :: Rabbit p70 S6 Kinase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9406738
Unit / Price
0.05 mL  /  $200 +1 FREE 8GB USB
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

p70 S6 Kinase (RPS6KB1), Polyclonal Antibody

★Popular Item★
 Also Known As   

p70 S6 Kinase (Phospho-Ser424) Antibody

 Product Synonym Names    KS6B1; P70-S6K; RPS6KB1; S6K
 Product Gene Name   

anti-RPS6KB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    608938
 3D Structure    ModBase 3D Structure for P23443
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    The antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 424.
 Purity/Purification    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
 Form/Format    Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen Type    Peptide-KLH
 Immunogen Description    Peptide sequence around phosphorylation site of serine 424 (P-V-S(p)-P-V) derived from Human p70 S6 Kinase.
 Modification    Phospho-Ser424
 Target Name    p70 S6 Kinase
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 Preparation and Storage    Store at -20 degree C for long term preservation (recommended). Store at 4 degree C for short term use.
 Other Notes    Small volumes of anti-RPS6KB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPS6KB1 antibody

   Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.
 Product Categories/Family for anti-RPS6KB1 antibody    Phospho-specific Ab
 Applications Tested/Suitable for anti-RPS6KB1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-RPS6KB1 antibody    Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200
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 Western Blot (WB) of anti-RPS6KB1 antibody    Western blot analysis of extracts from MCF cells untreated or treated with EGF using p70 S6 Kinase(Phospho-Ser424) Antibody.
anti-RPS6KB1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-RPS6KB1 antibody    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase(Phospho-Ser424) Antibody (left) or the same antibody preincubated with blocking peptide(right).
anti-RPS6KB1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-RPS6KB1 antibody    Immunofluorescence staining of methanol-fixed Hela cells showing cytoplasmic, centrosomal and nuclear staining using p70 S6 Kinase(Phospho-Ser424) Antibody.
anti-RPS6KB1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for RPS6KB1. It may not necessarily be applicable to this product.
 NCBI GI #    440546395
 NCBI GeneID    6198
 NCBI Accession #    NP_001258971.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001272042.1 [Other Products]
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 UniProt Primary Accession #    P23443 [Other Products]
 UniProt Secondary Accession #    Q7Z721; B2R779; B4DLT4; B4DTG1; E7ESB8; F6UYM1 [Other Products]
 UniProt Related Accession #    P23443 [Other Products]
 Molecular Weight    51,016 Da [Similar Products]
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 NCBI Official Full Name    ribosomal protein S6 kinase beta-1 isoform b
 NCBI Official Synonym Full Names    ribosomal protein S6 kinase, 70kDa, polypeptide 1
 NCBI Official Symbol    RPS6KB1 [Similar Products]
 NCBI Official Synonym Symbols   
S6K; PS6K; S6K1; STK14A; p70-S6K; p70 S6KA; p70-alpha; S6K-beta-1; p70(S6K)-alpha
[Similar Products]
 NCBI Protein Information    ribosomal protein S6 kinase beta-1
 UniProt Protein Name    Ribosomal protein S6 kinase beta-1
 UniProt Synonym Protein Names   
70 kDa ribosomal protein S6 kinase 1; P70S6K1; p70-S6K 1; Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA
 Protein Family    Ribosomal protein S6 kinase
 UniProt Gene Name    RPS6KB1 [Similar Products]
 UniProt Synonym Gene Names    STK14A; S6K-beta-1; S6K1; P70S6K1; p70-S6K 1; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA [Similar Products]
 UniProt Entry Name    KS6B1_HUMAN
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 NCBI Summary for RPS6KB1    This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
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 UniProt Comments for RPS6KB1    p70S6K: an AGC kinase of the RSK family that is required for cell growth and G1 cell cycle progression. Is phosphorylated and activated by mTOR in mitogenic pathways downstream of phosphoinositide 3 kinase (PI3K). Phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs. Activity is controlled by multiple phosphorylation events located within the catalytic, linker and pseudosubstrate domains. Mouse knockout shows symptoms of insulin resistance, and increased insulin senstivity, resulting in protection against diet-induced obesity. Protein expression and activation upregulated in colon adenocarcinoma cell lines. Increased expression in breast cancer correlated with poor survival. Selectively amplified and overexpressed within the 17q23 breast cancer amplicon. Two isoforms produced by alternative initiation have been reported.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, AGC; Translation; AGC group; RSK family; p70 subfamily

Chromosomal Location of Human Ortholog: 17q23.1
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 Research Articles on RPS6KB1    1. Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-RPS6KB1 antibodyPathways associated with anti-RPS6KB1 antibody
 Reference Product  PubMed Publications
 MTOR antibody  >45 publications with RPS6KB1 and MTOR
 AKT1 antibody  >9 publications with RPS6KB1 and AKT1
 RPS6 antibody  >8 publications with RPS6KB1 and RPS6
 RHEB antibody  >4 publications with RPS6KB1 and RHEB
 IRS1 antibody  >4 publications with RPS6KB1 and IRS1
 RICTOR antibody  >3 publications with RPS6KB1 and RICTOR
 RAC1 antibody  >1 publications with RPS6KB1 and RAC1
 RPTOR antibody  >1 publications with RPS6KB1 and RPTOR
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Acute Myeloid Leukemia Pathway antibodies  Acute Myeloid Leukemia Pathway Diagram
 Angiopoietin Receptor Tie2-mediated Signaling Pathway antibodies  Angiopoietin Receptor Tie2-mediated Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 Choline Metabolism In Cancer Pathway antibodies  Choline Metabolism In Cancer Pathway Diagram
Diseases associated with anti-RPS6KB1 antibodyOrgans/Tissues associated with anti-RPS6KB1 antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >13 publications with RPS6KB1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >8 publications with RPS6KB1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >6 publications with RPS6KB1 and Neoplasms, Experimental
 Inflammation Antibodies  >5 publications with RPS6KB1 and Inflammation
 Liver Neoplasms Antibodies  >3 publications with RPS6KB1 and Liver Neoplasms
 Liver Diseases Antibodies  >3 publications with RPS6KB1 and Liver Diseases
 Insulin Resistance Antibodies  >3 publications with RPS6KB1 and Insulin Resistance
 Ovarian Neoplasms Antibodies  >3 publications with RPS6KB1 and Ovarian Neoplasms
 Lung Neoplasms Antibodies  >2 publications with RPS6KB1 and Lung Neoplasms
 Heart Diseases Antibodies  >2 publications with RPS6KB1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with RPS6KB1 and Brain
 Muscle Antibodies  >6 publications with RPS6KB1 and Muscle
 Liver Antibodies  >5 publications with RPS6KB1 and Liver
 Prostate Antibodies  >3 publications with RPS6KB1 and Prostate
 Heart Antibodies  >3 publications with RPS6KB1 and Heart
 Blood Antibodies  >3 publications with RPS6KB1 and Blood
 Lung Antibodies  >2 publications with RPS6KB1 and Lung
 Pancreas Antibodies  >2 publications with RPS6KB1 and Pancreas
 Intestine Antibodies  >2 publications with RPS6KB1 and Intestine
 Kidney Antibodies  >2 publications with RPS6KB1 and Kidney
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