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anti-PLIN3 antibody :: Goat perilipin 3/TIP47 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422908
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

perilipin 3/TIP47 (PLIN3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-perilipin 3/TIP47 (aa154-167) Antibody

 Product Synonym Names    PLIN3; perilipin 3; M6PRBP1; MGC11117; MGC2012; PP17; TIP47; 47 kDa MPR-binding protein; cargo selection protein TIP47; mannose-6-phosphate receptor-binding protein 1; perilipin-3; placental protein 17; tail-interacting protein, 47 kD; PLIN3 antibody; perilipin 3 antibody; M6PRBP1 antibody; MGC11117 antibody; MGC2012 antibody; PP17 antibody; TIP47 antibody; 47 kDa MPR-binding protein antibody; cargo selection protein TIP47 antibody; mannose-6-phosphate receptor-binding protein 1 antibody; perilipin-3 antibody; placental protein 17 antibody; tail-interacting protein; 47 kD antibody; perilipin 3; TIP47; perilipin 3 / TIP47 (aa154-167)
 Product Gene Name   

anti-PLIN3 antibody

[Similar Products]
 Antibody/Peptide Pairs    perilipin 3 / TIP47 peptide (MBS427778) is used for blocking the activity of perilipin 3/TIP47 antibody (MBS422908)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TRGAVQSGVD KTKS
 OMIM    602702
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
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 Immunogen    Peptide with sequence C-TRGAVQSGVDKTKS, from the internal region of the protein sequence according to NP_005808.3; NP_001157661.1; NP_001157666.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize all reported isoforms (NP_005808.3; NP_001157661.1; NP_001157666.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-PLIN3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLIN3 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-PLIN3 antibody    Peptide ELISA: Antibody detection limit dilution 1: 128000.
Western Blot: Approx 48kDa+45kDa double bands observed in lysates of cell line HeLa and of Human Colon cancer (calculated MW of 47.1kDa according to NP_NP_005808.3, 46.9kDa according to NP_001157661.1 and 45.8kDa according to NP_001157666.1). The observed bands represent the three different isoforms. Please note the difference in band pattern intensities between HeLa and Colon cancer lysates. Recommended concentration: 0. 03-0.1ug/ml.
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 Western Blot (WB) of anti-PLIN3 antibody    (0. 03ug/ml) staining of HeLa (lane 1) and Human Colon cancer (lane two) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-PLIN3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for PLIN3. It may not necessarily be applicable to this product.
 NCBI GI #    255958282
 NCBI GeneID    10226
 NCBI Accession #    NP_005808.3 [Other Products]
 NCBI Related Accession #    NP_001157661.1; NP_001157666.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005817.4 [Other Products]
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 UniProt Secondary Accession #    Q53G77; Q9BS03; Q9UBD7; Q9UP92; A8K4Y9; K7EQF4 [Other Products]
 UniProt Related Accession #    O60664 [Other Products]
 Molecular Weight    45,803 Da
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 NCBI Official Full Name    perilipin-3 isoform 1
 NCBI Official Synonym Full Names    perilipin 3
 NCBI Official Symbol    PLIN3 [Similar Products]
 NCBI Official Synonym Symbols   
PP17; TIP47; M6PRBP1
[Similar Products]
 NCBI Protein Information    perilipin-3
 UniProt Protein Name    Perilipin-3
 UniProt Synonym Protein Names   
47 kDa mannose 6-phosphate receptor-binding protein; 47 kDa MPR-binding protein; Cargo selection protein TIP47; Mannose-6-phosphate receptor-binding protein 1; Placental protein 17; PP17
 Protein Family    Perilipin
 UniProt Gene Name    PLIN3 [Similar Products]
 UniProt Synonym Gene Names    M6PRBP1; TIP47; 47 kDa MPR-binding protein; PP17 [Similar Products]
 UniProt Entry Name    PLIN3_HUMAN
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 NCBI Summary for PLIN3    Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
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 UniProt Comments for PLIN3    perilipin 3: a membrane-associated protein and a coat protein for lipid droplets (LDs). It has been described as a mannose-6-phosphate receptor (MPR) binding protein required for endosome-to-Golgi transport of MPRs, but this function has been disputed. Interacts with M6PR and IGF2R via their cytoplasmic domains. Affects hepatic lipid and glucose metabolism. Belongs to the perilipin family. 3 isoforms of the human protein are produced by alternative splicing. Isoform 2 may exist as a homodimer known as PP17C.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: cytoplasm; cytosol; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bound organelle; lipid particle; membrane; transport vesicle

Molecular Function: protein binding

Biological Process: vesicle-mediated transport
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 Research Articles on PLIN3    1. PLIN3 functions are intertwined with the lipogenic pathways implicated in sebaceous lipogenesis, such as desaturation and triglyceride synthesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-PLIN3 antibodyDiseases associated with anti-PLIN3 antibody
 Products by Pathway  Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway antibodies  Intra-Golgi And Retrograde Golgi-to-ER Traffic Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Retrograde Transport At The Trans-Golgi-Network Pathway antibodies  Retrograde Transport At The Trans-Golgi-Network Pathway Diagram
 Vesicle-mediated Transport Pathway antibodies  Vesicle-mediated Transport Pathway Diagram
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >13 publications with PLIN3 and Fatty Liver
 Liver Diseases Antibodies  >13 publications with PLIN3 and Liver Diseases
 Uterine Cervical Neoplasms Antibodies  >5 publications with PLIN3 and Uterine Cervical Neoplasms
 Kidney Diseases Antibodies  >4 publications with PLIN3 and Kidney Diseases
 Inflammation Antibodies  >4 publications with PLIN3 and Inflammation
 Liver Neoplasms Antibodies  >3 publications with PLIN3 and Liver Neoplasms
 Glucose Intolerance Antibodies  >2 publications with PLIN3 and Glucose Intolerance
 Nephritis Antibodies  >1 publications with PLIN3 and Nephritis
 Weight Loss Antibodies  >1 publications with PLIN3 and Weight Loss
 Prostatic Diseases Antibodies  >1 publications with PLIN3 and Prostatic Diseases
Organs/Tissues associated with anti-PLIN3 antibody
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >22 publications with PLIN3 and Muscle
 Liver Antibodies  >20 publications with PLIN3 and Liver
 Blood Antibodies  >14 publications with PLIN3 and Blood
 Bone Antibodies  >10 publications with PLIN3 and Bone
 Connective Tissue Antibodies  >9 publications with PLIN3 and Connective Tissue
 Kidney Antibodies  >5 publications with PLIN3 and Kidney
 Placenta Antibodies  >5 publications with PLIN3 and Placenta
 Bone Marrow Antibodies  >4 publications with PLIN3 and Bone Marrow
 Embryonic Tissue Antibodies  >4 publications with PLIN3 and Embryonic Tissue
 Heart Antibodies  >3 publications with PLIN3 and Heart
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