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anti-PITRM1 antibody :: Rabbit pitrilysin metallopeptidase 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716856 anti-PITRM1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

pitrilysin metallopeptidase 1 (PITRM1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human pitrilysin metallopeptidase 1 polyclonal Antibody

 Product Synonym Names    pitrilysin metallopeptidase 1; PITRM1; KIAA1104; MGC138192; MGC141929; MP1; PreP; hMP1
 Product Gene Name   

anti-PITRM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PITRM1
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-82316
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PITRM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PITRM1 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PITRM1. It may not necessarily be applicable to this product.
 NCBI GI #    109731666
 NCBI GeneID    10531
 NCBI Accession #    AAI13370.1 [Other Products]
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 UniProt Secondary Accession #    O95204; Q2M2G6; Q4VBR1; Q5JRW7; Q7L5Z7; Q9BSI6; Q9BVJ5; B3KMJ6; B4E0J8; C9JSL2; E7ES23 [Other Products]
 UniProt Related Accession #    Q5JRX3 [Other Products]
 Molecular Weight    106,065 Da [Similar Products]
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 NCBI Official Full Name    Pitrilysin metallopeptidase 1
 NCBI Official Synonym Full Names    pitrilysin metallopeptidase 1
 NCBI Official Symbol    PITRM1 [Similar Products]
 NCBI Official Synonym Symbols   
MP1; PreP
[Similar Products]
 NCBI Protein Information    presequence protease, mitochondrial; PreP peptidasome; pitrilysin metalloproteinase 1; metalloprotease 1 (pitrilysin family)
 UniProt Protein Name    Presequence protease, mitochondrial
 UniProt Synonym Protein Names   
Pitrilysin metalloproteinase 1; Metalloprotease 1; hMP1
 UniProt Gene Name    PITRM1 [Similar Products]
 UniProt Synonym Gene Names    KIAA1104; MP1; hPreP; Metalloprotease 1; hMP1 [Similar Products]
 UniProt Entry Name    PREP_HUMAN
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 UniProt Comments for PITRM1    PITRM1: ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference. Belongs to the peptidase M16 family. PreP subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Activator; Mitochondrial; Protease

Chromosomal Location of Human Ortholog: 10p15.2

Cellular Component: mitochondrion; mitochondrial matrix

Molecular Function: metal ion binding; metalloendopeptidase activity; enzyme activator activity

Biological Process: positive regulation of catalytic activity; proteolysis
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 Research Articles on PITRM1    1. Data show that the hPreP presequence only targets GFP to the matrix of mammalian and yeast mitochondria.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-PITRM1 antibodyOrgans/Tissues associated with anti-PITRM1 antibody
 Disease Name  Pubmed Publications
 Embryo Loss Antibodies  >1 publications with PITRM1 and Embryo Loss
 Kidney Diseases Antibodies  >1 publications with PITRM1 and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with PITRM1 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with PITRM1 and Muscle
 Liver Antibodies  >2 publications with PITRM1 and Liver
 Placenta Antibodies  >2 publications with PITRM1 and Placenta
 Lung Antibodies  >2 publications with PITRM1 and Lung
 Brain Antibodies  >2 publications with PITRM1 and Brain
 Pancreas Antibodies  >1 publications with PITRM1 and Pancreas
 Heart Antibodies  >1 publications with PITRM1 and Heart
 Embryonic Tissue Antibodies  >1 publications with PITRM1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with PITRM1 and Kidney
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