BAP74121.1
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NCBI Official Full Name
polo-like kinase 4
NCBI Summary for polo-like kinase 4
This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Comments for polo-like kinase 4
PLK4: a kinase of the PLK family. Localizes to centrosomes and the cleavage furrow during cytokinesis. Interacts with the protein kinase Tec.
Protein type: Protein kinase, Other; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.21; Nucleolus; Other group; PLK family
Chromosomal Location of Human Ortholog: 4q28
Cellular Component: centriole; centrosome; nucleolus; cytosol; cleavage furrow
Molecular Function: identical protein binding; protein serine/threonine kinase activity; protein binding; ATP binding
Biological Process: organelle organization and biogenesis; positive regulation of centriole replication; centriole replication; mitotic cell cycle; G2/M transition of mitotic cell cycle; protein amino acid phosphorylation
Disease: Microcephaly And Chorioretinopathy, Autosomal Recessive, 2
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