|
| Product Name
|
|
potassium inwardly-rectifying channel, subfamily J, member 10 (KCNJ10), Polyclonal Antibody ★Popular Item★
|
| Also Known As
|
|
Rabbit anti-human potassium inwardly-rectifying channel, subfamily J, member 10 polyclonal Antibody
|
| Product Synonym Names
|
|
potassium inwardly-rectifying channel; subfamily J; member 10; KCNJ10; BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1
|
| Product Gene Name
|
|
|
[Similar Products]
|
| Research Use Only
|
|
For Research Use Only. Not for use in diagnostic procedures.
|
 TOP
|
|
| OMIM
|
|
gene 612780
|
|
| Clonality
|
|
Polyclonal
|
| Isotype
|
|
IgG
|
| Host
|
|
Rabbit
|
| Species Reactivity
|
|
Human, Mouse, Rat
|
|
|
| Purity/Purification
|
|
Antigen Affinity Purified
|
|
|
| Immunogen
|
|
Human KCNJ10
|
| Storage Buffer
|
|
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
|
| Santa Cruz Alternative
|
|
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23637
|
|
|
| ISO Certification
|
|
Manufactured in an ISO 9001:2008 Certified Laboratory.
|
| Other Notes
|
|
Small volumes of anti-KCNJ10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
|
|
TOP
|
|
| Applications Tested/Suitable for anti-KCNJ10 antibody
|
|
ELISA (EIA), Western Blot (WB)
|
|
TOP
|
|
| NCBI/Uniprot data below describe general gene information for KCNJ10. It may not necessarily be applicable to this product. |
| NCBI GI #
|
|
119573134
|
| NCBI GeneID
|
|
3766
|
| NCBI Accession #
|
|
EAW52749.1
|
[Other Products]
|
|
|
| UniProt Secondary Accession #
|
|
Q5VUT9; Q8N4I7; Q92808; A3KME7
|
[Other Products]
|
| UniProt Related Accession #
|
|
P78508
|
[Other Products]
|
| Molecular Weight
|
|
42,508 Da
|
[Similar Products]
|
|
TOP
|
| NCBI Official Full Name
|
|
potassium inwardly-rectifying channel, subfamily J, member 10, isoform CRA_b
|
| NCBI Official Synonym Full Names
|
|
potassium inwardly-rectifying channel, subfamily J, member 10
|
| NCBI Official Symbol
|
|
KCNJ10
|
[Similar Products]
|
| NCBI Official Synonym Symbols
|
|
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN
|
[Similar Products]
|
| NCBI Protein Information
|
|
ATP-sensitive inward rectifier potassium channel 10; inward rectifier K+ channel KIR1.2; inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1
|
| UniProt Protein Name
|
|
ATP-sensitive inward rectifier potassium channel 10
|
| UniProt Synonym Protein Names
|
|
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
|
| Protein Family
|
|
ATP-sensitive inward rectifier potassium channel
|
| UniProt Gene Name
|
|
KCNJ10
|
[Similar Products]
|
| UniProt Entry Name
|
|
KCJ10_HUMAN
|
|
|
| NCBI Summary for KCNJ10
|
|
This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
|
|
|
| UniProt Comments for KCNJ10
|
|
Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.
Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 1q23.2
Cellular Component: microvillus; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane
Molecular Function: identical protein binding; protein binding; ATP-activated inward rectifier potassium channel activity; ATP binding; receptor binding
Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; response to glucocorticoid stimulus; membrane hyperpolarization; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; synaptic transmission; potassium ion import; visual perception; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; potassium ion homeostasis; potassium ion transport
Disease: Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct
|
|
TOP
|
|
| Research Articles on KCNJ10
|
|
1. No KIR4.1-specific antigen is detected in serum or cerebrospinal fluid of multiple sclerosis (MS) patients; the target antigen of MS remains elusive.
|
|
TOP
|
| Precautions
|
|
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
|
| Disclaimer
|
|
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
|
|
TOP
|
|
| Products associated with anti-KCNJ10 antibody | Pathways associated with anti-KCNJ10 antibody |
|
|
|
| Diseases associated with anti-KCNJ10 antibody | Organs/Tissues associated with anti-KCNJ10 antibody |
|
|
|
|
|
|
TOP
|
Antibody 
