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anti-KCNJ10 antibody :: Rabbit potassium inwardly-rectifying channel, subfamily J, member 10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS716317 anti-KCNJ10 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

potassium inwardly-rectifying channel, subfamily J, member 10 (KCNJ10), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human potassium inwardly-rectifying channel, subfamily J, member 10 polyclonal Antibody

 Product Synonym Names    potassium inwardly-rectifying channel; subfamily J; member 10; KCNJ10; BIRK-10; KCNJ13-PEN; KIR1.2; KIR4.1
 Product Gene Name   

anti-KCNJ10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612780
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human KCNJ10
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-23637
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KCNJ10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KCNJ10 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for KCNJ10. It may not necessarily be applicable to this product.
 NCBI GI #    119573134
 NCBI GeneID    3766
 NCBI Accession #    EAW52749.1 [Other Products]
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 UniProt Secondary Accession #    Q5VUT9; Q8N4I7; Q92808; A3KME7 [Other Products]
 UniProt Related Accession #    P78508 [Other Products]
 Molecular Weight    42,508 Da [Similar Products]
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 NCBI Official Full Name    potassium inwardly-rectifying channel, subfamily J, member 10, isoform CRA_b
 NCBI Official Synonym Full Names    potassium inwardly-rectifying channel, subfamily J, member 10
 NCBI Official Symbol    KCNJ10 [Similar Products]
 NCBI Official Synonym Symbols   
KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 10; inward rectifier K+ channel KIR1.2; inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1; potassium channel, inwardly rectifying subfamily J member 10; glial ATP-dependent inwardly rectifying potassium channel KIR4.1
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 10
 UniProt Synonym Protein Names   
ATP-dependent inwardly rectifying potassium channel Kir4.1; Inward rectifier K(+) channel Kir1.2; Potassium channel, inwardly rectifying subfamily J member 10
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ10 [Similar Products]
 UniProt Entry Name    KCJ10_HUMAN
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 NCBI Summary for KCNJ10    This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNJ10    Kir4.1: May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Defects in KCNJ10 are the cause of seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SESAMES). A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ10 subfamily.

Protein type: Channel, potassium; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 1q23.2

Cellular Component: microvillus; integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: identical protein binding; protein binding; ATP-activated inward rectifier potassium channel activity; ATP binding; receptor binding

Biological Process: regulation of long-term neuronal synaptic plasticity; myelination in the central nervous system; response to glucocorticoid stimulus; membrane hyperpolarization; response to blue light; glutamate uptake during transmission of nerve impulse; response to mineralocorticoid stimulus; adult walking behavior; protein homotetramerization; synaptic transmission; potassium ion import; visual perception; optic nerve development; regulation of resting membrane potential; regulation of sensory perception of pain; inflammatory response; potassium ion homeostasis; potassium ion transport

Disease: Pendred Syndrome; Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance; Deafness, Autosomal Recessive 4, With Enlarged Vestibular Aqueduct
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 Research Articles on KCNJ10    1. No KIR4.1-specific antigen is detected in serum or cerebrospinal fluid of multiple sclerosis (MS) patients; the target antigen of MS remains elusive.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNJ10 antibodyPathways associated with anti-KCNJ10 antibody
 Reference Product  PubMed Publications
 SLC26A4 antibody  >20 publications with KCNJ10 and SLC26A4
 KCNJ16 antibody  >6 publications with KCNJ10 and KCNJ16
 AQP4 antibody  >1 publications with KCNJ10 and AQP4
 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 GABA B Receptor Activation Pathway antibodies  GABA B Receptor Activation Pathway Diagram
 GABA Receptor Activation Pathway antibodies  GABA Receptor Activation Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway antibodies  Inhibition Of Voltage Gated Ca2+ Channels Via Gbeta/gamma Subunits Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
Diseases associated with anti-KCNJ10 antibodyOrgans/Tissues associated with anti-KCNJ10 antibody
 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >13 publications with KCNJ10 and Neurobehavioral Manifestations
 Kidney Diseases Antibodies  >8 publications with KCNJ10 and Kidney Diseases
 SeSAME syndrome Antibodies  >8 publications with KCNJ10 and SeSAME syndrome
 Aneuploidy Antibodies  >2 publications with KCNJ10 and Aneuploidy
 Nervous System Malformations Antibodies  >1 publications with KCNJ10 and Nervous System Malformations
 Heart Diseases Antibodies  >1 publications with KCNJ10 and Heart Diseases
 Inflammation Antibodies  >1 publications with KCNJ10 and Inflammation
 Birth Weight Antibodies  >1 publications with KCNJ10 and Birth Weight
 Hypertrophy Antibodies  >1 publications with KCNJ10 and Hypertrophy
 Weight Gain Antibodies  >1 publications with KCNJ10 and Weight Gain
 Organ/Tissue Name  Pubmed Publications
 Ear Antibodies  >35 publications with KCNJ10 and Ear
 Kidney Antibodies  >21 publications with KCNJ10 and Kidney
 Brain Antibodies  >19 publications with KCNJ10 and Brain
 Nerve Antibodies  >6 publications with KCNJ10 and Nerve
 Blood Antibodies  >5 publications with KCNJ10 and Blood
 Eye Antibodies  >4 publications with KCNJ10 and Eye
 Ganglia Antibodies  >3 publications with KCNJ10 and Ganglia
 Spleen Antibodies  >1 publications with KCNJ10 and Spleen
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