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anti-proBNP antibody :: Rabbit proBNP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540055 anti-proBNP antibody
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

proBNP, Polyclonal Antibody

★Popular Item★
 Also Known As   

proBNP Antibody

 Product Synonym Names    BNP 32; BNP; BNP(1-32); BNP(5-29); Brain Natriuretic Peptide 32; Gamma brain natriuretic peptide; Natriuretic peptide precursor type B; NPPB antibody
 Product Gene Name   

anti-proBNP antibody

[Similar Products]
 Matching Pairs    Antibody: proBNP (MBS540055)
Positive Control: proBNP (MBS543049)
 Antibody/Peptide Pairs    proBNP peptide (MBS544138) is used for blocking the activity of proBNP antibody (MBS540055)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600295
 3D Structure    ModBase 3D Structure for P16860
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Specificity    No cross reactivity with proANP.
 Form/Format    Affinity Purified
 Concentration    0.8 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 100-150 on human proBNP.
 Expression    Is expressed in the brain and atria, however it is expressed at much lower levels than ANP.
 Molecular Function    Diuretic hormone activity, Hormone, Vasoactive
 Subcellular Location    Secreted
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-proBNP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-proBNP antibody

   Affinity Purified Gamma-brain natriuretic peptide Antibody
A cardiac hormone that may also serve as a paracrine antifibrotic factor in the heart. Also functions in cardiovascular homeostasis via natriuresis, diuresis, vasorelaxation, and the inhibition of renin and aldosterone secretion.
 Product Categories/Family for anti-proBNP antibody    Primary Antibodies; Neuroscience; Neuropeptides & Hormones; proBNP Antibody
 Applications Tested/Suitable for anti-proBNP antibody   

Confocal Microscopy (CM), ELISA (EIA), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

 Application Notes for anti-proBNP antibody    Confocal Microscopy||1:200
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunocytochemistry: 1:200
Immunofluorescence: 1:200
Immunohistochemistry: 1:200
Immunoprecipitation: 1:200
Western Blot: 1:500
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NCBI/Uniprot data below describe general gene information for proBNP. It may not necessarily be applicable to this product.
 NCBI GI #    113836
 NCBI GeneID    4879
 NCBI Accession #    P16860.1 [Other Products]
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 UniProt Primary Accession #    P16860 [Other Products]
 UniProt Secondary Accession #    Q6FGY0; Q9P2Q7; B0ZBE9 [Other Products]
 UniProt Related Accession #    P16860 [Other Products]
 Molecular Weight    14,726 Da
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 NCBI Official Full Name    Natriuretic peptides B
 NCBI Official Synonym Full Names    natriuretic peptide B
 NCBI Official Symbol    NPPB [Similar Products]
 NCBI Official Synonym Symbols   
BNP
[Similar Products]
 NCBI Protein Information    natriuretic peptides B
 UniProt Protein Name    Natriuretic peptides B
 UniProt Synonym Protein Names   
Gamma-brain natriuretic peptide
 UniProt Gene Name    NPPB [Similar Products]
 UniProt Synonym Gene Names    BNP(1-32); BNP-32 [Similar Products]
 UniProt Entry Name    ANFB_HUMAN
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 NCBI Summary for proBNP    This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
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 UniProt Comments for proBNP    NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Secreted; Hormone; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.2

Cellular Component: extracellular region; extracellular space; protein complex

Molecular Function: diuretic hormone activity; hormone activity; protein binding; receptor binding

Biological Process: body fluid secretion; cell surface receptor linked signal transduction; cGMP biosynthetic process; negative regulation of angiogenesis; negative regulation of cell growth; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; regulation of vasodilation
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 Research Articles on proBNP    1. Low serum sodium was associated with an increased risk of cardiovascular and all-cause mortality in type 2 diabetes, but association was not explained by NT-proBNP.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-proBNP antibodyPathways associated with anti-proBNP antibody
 Reference Product  PubMed Publications
 NPPA antibody  >57 publications with proBNP and NPPA
 NPR3 antibody  >9 publications with proBNP and NPR3
 NPR1 antibody  >8 publications with proBNP and NPR1
 NPR2 antibody  >5 publications with proBNP and NPR2
 CYP1A2 antibody  >1 publications with proBNP and CYP1A2
 ATF2 antibody  >1 publications with proBNP and ATF2
 IDE antibody  >1 publications with proBNP and IDE
 Products by Pathway  Pathway Diagram
 MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies  MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
 CGMP-PKG Signaling Pathway antibodies  CGMP-PKG Signaling Pathway Diagram
Diseases associated with anti-proBNP antibodyOrgans/Tissues associated with anti-proBNP antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >145 publications with proBNP and Fibrosis
 Cardiovascular Diseases Antibodies  >88 publications with proBNP and Cardiovascular Diseases
 Heart Diseases Antibodies  >48 publications with proBNP and Heart Diseases
 Hypertension Antibodies  >30 publications with proBNP and Hypertension
 Heart Failure Antibodies  >25 publications with proBNP and Heart Failure
 Hypertrophy Antibodies  >24 publications with proBNP and Hypertrophy
 Edema Antibodies  >17 publications with proBNP and Edema
 Inflammation Antibodies  >16 publications with proBNP and Inflammation
 Myocardial Infarction Antibodies  >14 publications with proBNP and Myocardial Infarction
 Necrosis Antibodies  >14 publications with proBNP and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >148 publications with proBNP and Kidney
 Heart Antibodies  >106 publications with proBNP and Heart
 Lung Antibodies  >65 publications with proBNP and Lung
 Liver Antibodies  >44 publications with proBNP and Liver
 Pancreas Antibodies  >29 publications with proBNP and Pancreas
 Embryonic Tissue Antibodies  >16 publications with proBNP and Embryonic Tissue
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