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anti-PLOD2 antibody :: Rabbit procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713978 anti-PLOD2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 (PLOD2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 polyclonal Antibody

 Product Synonym Names    procollagen-lysine; 2-oxoglutarate 5-dioxygenase 2; PLOD2; LH2; TLH
 Product Gene Name   

anti-PLOD2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609220
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PLOD2
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50067 / sc-50068
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PLOD2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PLOD2 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PLOD2. It may not necessarily be applicable to this product.
 NCBI GI #    22713625
 NCBI GeneID    5352
 NCBI Accession #    AAH37169.1 [Other Products]
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 UniProt Secondary Accession #    Q59ED2; Q8N170 [Other Products]
 UniProt Related Accession #    O00469 [Other Products]
 Molecular Weight    87,098 Da [Similar Products]
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 NCBI Official Full Name    Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 NCBI Official Synonym Full Names    procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
 NCBI Official Symbol    PLOD2 [Similar Products]
 NCBI Official Synonym Symbols   
LH2; TLH
[Similar Products]
 NCBI Protein Information    procollagen-lysine,2-oxoglutarate 5-dioxygenase 2; lysyl hydroxlase 2; lysyl hydroxylase 2; lysine hydroxylase 2; telopeptide lysyl hydroxylase
 UniProt Protein Name    Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
 UniProt Synonym Protein Names   
Lysyl hydroxylase 2; LH2
 Protein Family    Procollagen-lysine,2-oxoglutarate 5-dioxygenase
 UniProt Gene Name    PLOD2 [Similar Products]
 UniProt Synonym Gene Names    LH2 [Similar Products]
 UniProt Entry Name    PLOD2_HUMAN
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 NCBI Summary for PLOD2    The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PLOD2    PLOD2: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. Defects in PLOD2 are the cause of Bruck syndrome type 2 (BRKS2). Bruck syndrome, also known as osteogenesis imperfecta with congenital joint contractures, is an autosomal recessive disease characterized by generalized osteopenia, joint contractures at birth, fragile bones and short stature. It can be distinguished from osteogenesis imperfecta by the absence of hearing loss and dentinogenesis imperfecta, and by the presence of clubfoot and congenital joint limitations. The molecular defect is an aberrant cross-linking of bone collagen, due to underhydroxylation of lysine residues within the telopeptides of type I collagen, whereas the lysine residues in the triple helix are normal. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Endoplasmic reticulum; Oxidoreductase; Amino Acid Metabolism - lysine degradation; EC 1.14.11.4

Chromosomal Location of Human Ortholog: 3q24

Cellular Component: endoplasmic reticulum membrane; endoplasmic reticulum; rough endoplasmic reticulum membrane

Molecular Function: L-ascorbic acid binding; iron ion binding; procollagen-lysine 5-dioxygenase activity

Biological Process: extracellular matrix organization and biogenesis; response to hypoxia; protein modification process

Disease: Bruck Syndrome 2
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 Research Articles on PLOD2    1. TGFbeta induced PLOD2/LH2 expression in human synovial osteoarthritic fibroblasts through ALK5 signaling.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLOD2 antibodyPathways associated with anti-PLOD2 antibody
 Reference Product  PubMed Publications
 PLOD3 antibody  >6 publications with PLOD2 and PLOD3
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
Diseases associated with anti-PLOD2 antibodyOrgans/Tissues associated with anti-PLOD2 antibody
 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >13 publications with PLOD2 and Fibrosis
 Congenital Abnormalities Antibodies  >9 publications with PLOD2 and Congenital Abnormalities
 Bruck syndrome 2 Antibodies  >8 publications with PLOD2 and Bruck syndrome 2
 Disease Models, Animal Antibodies  >3 publications with PLOD2 and Disease Models, Animal
 Neoplasms, Experimental Antibodies  >3 publications with PLOD2 and Neoplasms, Experimental
 Osteoarthritis Antibodies  >3 publications with PLOD2 and Osteoarthritis
 Liver Diseases Antibodies  >2 publications with PLOD2 and Liver Diseases
 Breast Neoplasms Antibodies  >2 publications with PLOD2 and Breast Neoplasms
 Necrosis Antibodies  >2 publications with PLOD2 and Necrosis
 Adenocarcinoma Antibodies  >2 publications with PLOD2 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >19 publications with PLOD2 and Bone
 Connective Tissue Antibodies  >14 publications with PLOD2 and Connective Tissue
 Skin Antibodies  >11 publications with PLOD2 and Skin
 Vascular Antibodies  >7 publications with PLOD2 and Vascular
 Muscle Antibodies  >6 publications with PLOD2 and Muscle
 Liver Antibodies  >4 publications with PLOD2 and Liver
 Brain Antibodies  >4 publications with PLOD2 and Brain
 Embryonic Tissue Antibodies  >3 publications with PLOD2 and Embryonic Tissue
 Adipose Tissue Antibodies  >3 publications with PLOD2 and Adipose Tissue
 Bone Marrow Antibodies  >2 publications with PLOD2 and Bone Marrow
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