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anti-PRCP antibody :: Rabbit prolylcarboxypeptidase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710952
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

prolylcarboxypeptidase (PRCP), Polyclonal Antibody

 Also Known As   

Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody

 Product Synonym Names    prolylcarboxypeptidase (angiotensinase C); PRCP; HUMPCP; MGC2202; PCP
 Product Gene Name   

anti-PRCP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176785
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PRCP
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-49272 / sc-49274
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PRCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PRCP antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 SDS-PAGE of anti-PRCP antibody    Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
human brain tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400
anti-PRCP antibody SDS-PAGE image
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 SDS-PAGE of anti-PRCP antibody    Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
human liver tissue were subjected to SDS PAGE followed by western blot with PRCP antibody at dilution of 1:400
anti-PRCP antibody SDS-PAGE image
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 Immunohistochemical of paraffin of anti-PRCP antibody    Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 10x lens)
anti-PRCP antibody Immunohistochemical of paraffin image
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 Immunohistochemical of paraffin of anti-PRCP antibody    Rabbit anti-human prolylcarboxypeptidase (angiotensinase C) polyclonal Antibody
IgG
Non-conjugated
Antigen Affinity Purified
Positive WB detected in : Human brain tissue, human liver tissue
Positive IHC detected in :human lung cancer
Immunohistochemical of paraffin-embedded human lung cancer using PRCP antibody at dilution of 1:50 (under 40x lens)
anti-PRCP antibody Immunohistochemical of paraffin image
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NCBI/Uniprot data below describe general gene information for PRCP. It may not necessarily be applicable to this product.
 NCBI GI #    431321
 NCBI GeneID    5547
 NCBI Accession #    AAA99891.1 [Other Products]
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 UniProt Secondary Accession #    A8MU24; B2R7B7; B3KRK5; B5BU34 [Other Products]
 UniProt Related Accession #    P42785 [Other Products]
 Molecular Weight    58,100 Da [Similar Products]
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 NCBI Official Full Name    prolylcarboxypeptidase
 NCBI Official Synonym Full Names    prolylcarboxypeptidase (angiotensinase C)
 NCBI Official Symbol    PRCP [Similar Products]
 NCBI Official Synonym Symbols   
PCP; HUMPCP
[Similar Products]
 NCBI Protein Information    lysosomal Pro-X carboxypeptidase; angiotensinase C; proline carboxypeptidase; lysosomal carboxypeptidase C; prolylcarboxypeptidase isoform 1 preproprotein
 UniProt Protein Name    Lysosomal Pro-X carboxypeptidase
 UniProt Synonym Protein Names   
Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP
 Protein Family    Lysosomal Pro-X carboxypeptidase
 UniProt Gene Name    PRCP [Similar Products]
 UniProt Synonym Gene Names    PCP; PRCP [Similar Products]
 UniProt Entry Name    PCP_HUMAN
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 NCBI Summary for PRCP    The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRCP    PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family.

Protein type: EC 3.4.16.2; Protease

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: lysosome; plasma membrane

Molecular Function: serine carboxypeptidase activity; protein binding

Biological Process: negative regulation of systemic arterial blood pressure; plasma kallikrein-kinin cascade; glucose homeostasis; blood coagulation; proteolysis; regulation of blood vessel endothelial cell migration; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway
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 Research Articles on PRCP    1. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PRCP antibodyPathways associated with anti-PRCP antibody
 Reference Product  PubMed Publications
 PREP antibody  >2 publications with PRCP and PREP
 LRPAP1 antibody  >1 publications with PRCP and LRPAP1
 DPP4 antibody  >1 publications with PRCP and DPP4
 GBE1 antibody  >1 publications with PRCP and GBE1
 Products by Pathway  Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
Diseases associated with anti-PRCP antibodyOrgans/Tissues associated with anti-PRCP antibody
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >13 publications with PRCP and Hypertension
 Thrombosis Antibodies  >4 publications with PRCP and Thrombosis
 Inflammation Antibodies  >4 publications with PRCP and Inflammation
 Weight Loss Antibodies  >4 publications with PRCP and Weight Loss
 Brain Diseases Antibodies  >3 publications with PRCP and Brain Diseases
 Kidney Diseases Antibodies  >3 publications with PRCP and Kidney Diseases
 Hypertrophy Antibodies  >2 publications with PRCP and Hypertrophy
 Nervous System Malformations Antibodies  >1 publications with PRCP and Nervous System Malformations
 Fatty Liver Antibodies  >1 publications with PRCP and Fatty Liver
 Fibrosis Antibodies  >1 publications with PRCP and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >21 publications with PRCP and Blood
 Brain Antibodies  >19 publications with PRCP and Brain
 Vascular Antibodies  >11 publications with PRCP and Vascular
 Heart Antibodies  >7 publications with PRCP and Heart
 Kidney Antibodies  >5 publications with PRCP and Kidney
 Muscle Antibodies  >3 publications with PRCP and Muscle
 Lung Antibodies  >3 publications with PRCP and Lung
 Liver Antibodies  >3 publications with PRCP and Liver
 Embryonic Tissue Antibodies  >3 publications with PRCP and Embryonic Tissue
 Thyroid Antibodies  >2 publications with PRCP and Thyroid
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