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anti-PCSK5 antibody :: Rabbit proprotein convertase subtilisin/kexin type 5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS710997 anti-PCSK5 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

proprotein convertase subtilisin/kexin type 5 (PCSK5), Polyclonal Antibody

 Also Known As   

Rabbit anti-human proprotein convertase subtilisin/kexin type 5 polyclonal Antibody

 Product Synonym Names    proprotein convertase subtilisin/kexin type 5; PCSK5; PC5; PC6; PC6A; SPC6
 Product Gene Name   

anti-PCSK5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600488
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PCSK5
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22900 / sc-22901
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PCSK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PCSK5 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for PCSK5. It may not necessarily be applicable to this product.
 NCBI GI #    357529585
 NCBI GeneID    5125
 NCBI Accession #    Q92824.4 [Other Products]
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 UniProt Secondary Accession #    Q13527; Q96EP4; F5H2G7 [Other Products]
 UniProt Related Accession #    Q92824 [Other Products]
 Molecular Weight    101,649 Da [Similar Products]
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 NCBI Official Full Name    Proprotein convertase subtilisin/kexin type 5
 NCBI Official Synonym Full Names    proprotein convertase subtilisin/kexin type 5
 NCBI Official Symbol    PCSK5 [Similar Products]
 NCBI Official Synonym Symbols   
PC5; PC6; PC6A; SPC6
[Similar Products]
 NCBI Protein Information    proprotein convertase subtilisin/kexin type 5; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5
 UniProt Protein Name    Proprotein convertase subtilisin/kexin type 5
 UniProt Synonym Protein Names   
Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5
 Protein Family    Proprotein convertase subtilisin/kexin
 UniProt Gene Name    PCSK5 [Similar Products]
 UniProt Synonym Gene Names    PC5; PC6; PC5; PC6; hPC6 [Similar Products]
 UniProt Entry Name    PCSK5_HUMAN
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 NCBI Summary for PCSK5    This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
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 UniProt Comments for PCSK5    PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; EC 3.4.21.-; Protease

Chromosomal Location of Human Ortholog: 9q21.3

Cellular Component: Golgi apparatus; extracellular space; Golgi lumen; integral to membrane; secretory granule

Molecular Function: peptidase activity; serine-type endopeptidase activity; peptide binding

Biological Process: signal peptide processing; nerve growth factor receptor signaling pathway; heart development; respiratory tube development; cytokine biosynthetic process; embryonic skeletal development; peptide hormone processing; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; nerve growth factor processing; cell-cell signaling; renin secretion into blood stream; protein processing; kidney development; embryonic gut development; embryo implantation
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 Research Articles on PCSK5    1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PCSK5 antibodyPathways associated with anti-PCSK5 antibody
 Reference Product  PubMed Publications
 FURIN antibody  >8 publications with PCSK5 and FURIN
 PCSK9 antibody  >4 publications with PCSK5 and PCSK9
 MBTPS1 antibody  >3 publications with PCSK5 and MBTPS1
 GDF11 antibody  >3 publications with PCSK5 and GDF11
 AMH antibody  >1 publications with PCSK5 and AMH
 REN antibody  >1 publications with PCSK5 and REN
 Products by Pathway  Pathway Diagram
 NGF Processing Pathway antibodies  NGF Processing Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
Diseases associated with anti-PCSK5 antibodyOrgans/Tissues associated with anti-PCSK5 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >3 publications with PCSK5 and Disease Models, Animal
 Heart Defects, Congenital Antibodies  >2 publications with PCSK5 and Heart Defects, Congenital
 Anus, Imperforate Antibodies  >2 publications with PCSK5 and Anus, Imperforate
 Cell Transformation, Neoplastic Antibodies  >1 publications with PCSK5 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with PCSK5 and Inflammation
 Liver Diseases Antibodies  >1 publications with PCSK5 and Liver Diseases
 Necrosis Antibodies  >1 publications with PCSK5 and Necrosis
 Lung Diseases Antibodies  >1 publications with PCSK5 and Lung Diseases
 Kidney Diseases Antibodies  >1 publications with PCSK5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >5 publications with PCSK5 and Heart
 Bone Antibodies  >5 publications with PCSK5 and Bone
 Intestine Antibodies  >4 publications with PCSK5 and Intestine
 Ovary Antibodies  >3 publications with PCSK5 and Ovary
 Kidney Antibodies  >3 publications with PCSK5 and Kidney
 Blood Antibodies  >3 publications with PCSK5 and Blood
 Embryonic Tissue Antibodies  >2 publications with PCSK5 and Embryonic Tissue
 Liver Antibodies  >2 publications with PCSK5 and Liver
 Lung Antibodies  >1 publications with PCSK5 and Lung
 Trachea Antibodies  >1 publications with PCSK5 and Trachea
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