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| Product Name
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proprotein convertase subtilisin/kexin type 5 (PCSK5), Polyclonal Antibody
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| Also Known As
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Rabbit anti-human proprotein convertase subtilisin/kexin type 5 polyclonal Antibody
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| Product Synonym Names
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proprotein convertase subtilisin/kexin type 5; PCSK5; PC5; PC6; PC6A; SPC6
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| Product Gene Name
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[Similar Products]
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| OMIM
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600488
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| Clonality
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Polyclonal
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| Isotype
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IgG
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| Host
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Rabbit
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| Species Reactivity
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Human, Mouse, Rat
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| Purity/Purification
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Antigen Affinity Purified
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| Immunogen
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Human PCSK5
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| Storage Buffer
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PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
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| Santa Cruz Alternative
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Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22900 / sc-22901
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| ISO Certification
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Manufactured in an ISO 9001:2008 Certified Laboratory.
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| Other Notes
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Small volumes of anti-PCSK5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for anti-PCSK5 antibody
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ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
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TOP
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| NCBI/Uniprot data below describe general gene information for PCSK5. It may not necessarily be applicable to this product. |
| NCBI GI #
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357529585
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| NCBI GeneID
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5125
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| NCBI Accession #
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Q92824.4
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[Other Products]
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| UniProt Secondary Accession #
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Q13527; Q96EP4; F5H2G7
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[Other Products]
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| UniProt Related Accession #
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Q92824
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[Other Products]
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| Molecular Weight
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101,649 Da
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[Similar Products]
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TOP
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| NCBI Official Full Name
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Proprotein convertase subtilisin/kexin type 5
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| NCBI Official Synonym Full Names
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proprotein convertase subtilisin/kexin type 5
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| NCBI Official Symbol
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PCSK5
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[Similar Products]
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| NCBI Official Synonym Symbols
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PC5; PC6; PC6A; SPC6
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[Similar Products]
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| NCBI Protein Information
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proprotein convertase subtilisin/kexin type 5; subtilase; protease PC6; prohormone convertase 5; proprotein convertase 6; subtilisin/kexin-like protease PC5
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| UniProt Protein Name
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Proprotein convertase subtilisin/kexin type 5
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| UniProt Synonym Protein Names
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Proprotein convertase 5; PC5; Proprotein convertase 6; PC6; hPC6; Subtilisin/kexin-like protease PC5
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| Protein Family
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Proprotein convertase subtilisin/kexin
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| UniProt Gene Name
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PCSK5
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[Similar Products]
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| UniProt Synonym Gene Names
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PC5; PC6; PC5; PC6; hPC6
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[Similar Products]
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| UniProt Entry Name
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PCSK5_HUMAN
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| NCBI Summary for PCSK5
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This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014]
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| UniProt Comments for PCSK5
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PCSK5: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2 and CALD1. Belongs to the peptidase S8 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; EC 3.4.21.-; Protease
Chromosomal Location of Human Ortholog: 9q21.3
Cellular Component: Golgi apparatus; extracellular space; Golgi lumen; integral to membrane; secretory granule
Molecular Function: peptidase activity; serine-type endopeptidase activity; peptide binding
Biological Process: signal peptide processing; nerve growth factor receptor signaling pathway; heart development; respiratory tube development; cytokine biosynthetic process; embryonic skeletal development; peptide hormone processing; viral infectious cycle; proteolysis; limb morphogenesis; peptide biosynthetic process; anterior/posterior pattern formation; nerve growth factor processing; cell-cell signaling; renin secretion into blood stream; protein processing; kidney development; embryonic gut development; embryo implantation
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TOP
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| Research Articles on PCSK5
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1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner
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TOP
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-PCSK5 antibody | Pathways associated with anti-PCSK5 antibody |
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| Diseases associated with anti-PCSK5 antibody | Organs/Tissues associated with anti-PCSK5 antibody |
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Antibody 
