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anti-REN antibody :: anti-Rat, mouse prorenin/renin IgG fraction, HRP labeled Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135147 anti-REN antibody
Unit / Price
1 mg  /  $395 +1 FREE 8GB USB
10 mg  /  $2,700 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

prorenin/renin IgG fraction, HRP labeled, Polyclonal Antibody

 Also Known As   

Sheep anti rat & mouse prorenin/renin IgG fraction, HRP labeled

 Product Gene Name   

anti-REN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 13; NC_005112.3 (55555583..55566812, complement). Location: 13q13
 3D Structure    ModBase 3D Structure for P08424
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Host: Sheep; Source: Sheep serum
 Species Reactivity    Rat, mouse
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    2.0 mg/ml (lot specific)
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 Immunogen    Recombinant full length rat protein fused to a His tag at C-terminal end (Glycosylated).
 Target Information    Recognises Renin/Prorenin
 Target Molecular Weight    44000
 Buffer    PBS, pH 7.4; 1% BSA, 0.01% Thimerosal
 Extinction Coefficient    1.36
 Preservative    Thimerosal
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-REN antibody

   Horseradish peroxidase labeled polyclonal antibody (host sheep) to rat prorenin. IgG fraction purified by immobilized Protein G.
 Product Categories/Family for anti-REN antibody    Renin/Prorenin; Polyclonal Antibodies to Rat and Mouse Prorenin/Renin
 Applications Tested/Suitable for anti-REN antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
 NCBI GI #    148747255
 NCBI GeneID    24715
 NCBI Accession #    NP_036774.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_012642.4 [Other Products]
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 UniProt Primary Accession #    P08424 [Other Products]
 UniProt Secondary Accession #    Q63497 [Other Products]
 UniProt Related Accession #    P08424 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    renin
 NCBI Official Synonym Full Names    renin
 NCBI Official Symbol    Ren [Similar Products]
 NCBI Official Synonym Symbols   
Ren1; RENAA; RATRENAA
[Similar Products]
 NCBI Protein Information    renin; angiotensinogenase; renin 1 structural
 UniProt Protein Name    Renin
 UniProt Synonym Protein Names   
Angiotensinogenase
 Protein Family    Protein
 UniProt Gene Name    Ren1 [Similar Products]
 UniProt Synonym Gene Names    Ren [Similar Products]
 UniProt Entry Name    RENI_RAT
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 NCBI Summary for REN    catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]
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 UniProt Comments for REN    REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.23.15; Protease

Cellular Component: extracellular space; membrane; cytoplasm; intracellular

Molecular Function: peptidase activity; insulin-like growth factor receptor binding; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to drug; response to cAMP; establishment of blood-nerve barrier; hormone-mediated signaling; renin-angiotensin regulation of aldosterone production; male gonad development; cell maturation; drinking behavior; response to lipopolysaccharide; angiotensin maturation; proteolysis; response to organic substance; regulation of MAPKKK cascade; regulation of blood pressure; beta-amyloid metabolic process; renin-angiotensin regulation of blood volume; mesonephros development; kidney development
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 Research Articles on REN    1. at least 4 BP loci reside within the 30-cM chromosome 13 BP quantitative trait locus that includes Renin
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-REN antibodyDiseases associated with anti-REN antibody
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin - Angiotensin System Pathway antibodies  Renin - Angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >711 publications with REN and Heart Diseases
 Hypertension Antibodies  >569 publications with REN and Hypertension
 Drug Toxicity Antibodies  >558 publications with REN and Drug Toxicity
 Necrosis Antibodies  >471 publications with REN and Necrosis
 Kidney Diseases Antibodies  >336 publications with REN and Kidney Diseases
 Myocardial Ischemia Antibodies  >316 publications with REN and Myocardial Ischemia
 Ischemia Antibodies  >301 publications with REN and Ischemia
 Fibrosis Antibodies  >285 publications with REN and Fibrosis
 Myocardial Infarction Antibodies  >198 publications with REN and Myocardial Infarction
 Hemorrhage Antibodies  >175 publications with REN and Hemorrhage
Organs/Tissues associated with anti-REN antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >1223 publications with REN and Brain
 Kidney Antibodies  >749 publications with REN and Kidney
 Eye Antibodies  >398 publications with REN and Eye
 Uncharacterized Tissue Antibodies  >5 publications with REN and Uncharacterized Tissue
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