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anti-PIAS3 antibody :: Rabbit protein inhibitor of activated STAT, 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711395 anti-PIAS3 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

protein inhibitor of activated STAT, 3 (PIAS3), Polyclonal Antibody

 Also Known As   

Rabbit anti-human protein inhibitor of activated STAT, 3 polyclonal Antibody

 Product Synonym Names    protein inhibitor of activated STAT; 3; PIAS3; FLJ14651; ZMIZ5
 Product Gene Name   

anti-PIAS3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605987
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PIAS3
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8154 / sc-14017
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PIAS3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PIAS3 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for PIAS3. It may not necessarily be applicable to this product.
 NCBI GI #    211827448
 NCBI GeneID    10401
 NCBI Accession #    AAH30556.2 [Other Products]
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 UniProt Secondary Accession #    Q9UFI3 [Other Products]
 UniProt Related Accession #    Q9Y6X2 [Other Products]
 Molecular Weight    68,017 Da [Similar Products]
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 NCBI Official Full Name    Protein inhibitor of activated STAT, 3
 NCBI Official Synonym Full Names    protein inhibitor of activated STAT, 3
 NCBI Official Symbol    PIAS3 [Similar Products]
 NCBI Official Synonym Symbols   
ZMIZ5
[Similar Products]
 NCBI Protein Information    E3 SUMO-protein ligase PIAS3; zinc finger, MIZ-type containing 5; protein inhibitor of activated STAT protein 3
 UniProt Protein Name    E3 SUMO-protein ligase PIAS3
 UniProt Synonym Protein Names   
Protein inhibitor of activated STAT protein 3
 Protein Family    E3 SUMO-protein ligase
 UniProt Gene Name    PIAS3 [Similar Products]
 UniProt Entry Name    PIAS3_HUMAN
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 NCBI Summary for PIAS3    This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PIAS3    PIAS3: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family.

Protein type: SUMO conjugating system; EC 6.3.2.-; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: dendrite; cytoplasm; synapse; nucleus

Molecular Function: protein C-terminus binding; protein binding; potassium channel regulator activity; enzyme binding; zinc ion binding; protein N-terminus binding; SUMO ligase activity; ligase activity

Biological Process: positive regulation of protein sumoylation; protein sumoylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; response to hormone stimulus; positive regulation of membrane potential
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 Research Articles on PIAS3    1. PIAS3 may be a potential biomarker target for early cancer detection and therapeutic of human colorectal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PIAS3 antibodyPathways associated with anti-PIAS3 antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >88 publications with PIAS3 and STAT3
 MITF antibody  >12 publications with PIAS3 and MITF
 IL6 antibody  >3 publications with PIAS3 and IL6
 JAK1 antibody  >3 publications with PIAS3 and JAK1
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 C-MYB Transcription Factor Network Pathway antibodies  C-MYB Transcription Factor Network Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 Interferon Type I Pathway antibodies  Interferon Type I Pathway Diagram
 Interleukin-11 Signaling Pathway antibodies  Interleukin-11 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Oncostatin M Signaling Pathway antibodies  Oncostatin M Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-PIAS3 antibodyOrgans/Tissues associated with anti-PIAS3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with PIAS3 and Inflammation
 Liver Diseases Antibodies  >7 publications with PIAS3 and Liver Diseases
 Prostatic Diseases Antibodies  >7 publications with PIAS3 and Prostatic Diseases
 Necrosis Antibodies  >7 publications with PIAS3 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with PIAS3 and Disease Models, Animal
 Adenocarcinoma Antibodies  >5 publications with PIAS3 and Adenocarcinoma
 Cardiovascular Diseases Antibodies  >4 publications with PIAS3 and Cardiovascular Diseases
 Liver Neoplasms Antibodies  >3 publications with PIAS3 and Liver Neoplasms
 Hepatitis Antibodies  >3 publications with PIAS3 and Hepatitis
 Kidney Diseases Antibodies  >2 publications with PIAS3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with PIAS3 and Blood
 Lung Antibodies  >13 publications with PIAS3 and Lung
 Brain Antibodies  >13 publications with PIAS3 and Brain
 Liver Antibodies  >11 publications with PIAS3 and Liver
 Bone Antibodies  >9 publications with PIAS3 and Bone
 Muscle Antibodies  >8 publications with PIAS3 and Muscle
 Prostate Antibodies  >7 publications with PIAS3 and Prostate
 Heart Antibodies  >6 publications with PIAS3 and Heart
 Bone Marrow Antibodies  >5 publications with PIAS3 and Bone Marrow
 Eye Antibodies  >4 publications with PIAS3 and Eye
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