NP_067045.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
protein prune homolog
NCBI Official Synonym Full Names
prune exopolyphosphatase
NCBI Protein Information
protein prune homolog; Drosophila-related expressed sequence 17
UniProt Protein Name
Protein prune homolog
UniProt Synonym Protein Names
Drosophila-related expressed sequence 17; DRES-17; DRES17; HTcD37
UniProt Synonym Gene Names
UniProt Entry Name
PRUNE_HUMAN
NCBI Summary for PRUNE
This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
UniProt Comments for PRUNE
PRUNE: Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. Belongs to the PPase class C family. Prune subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.6.1.1; Hydrolase; Nucleotide Metabolism - purine
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: focal adhesion; cytoplasm; nucleus
Molecular Function: protein binding; inorganic diphosphatase activity; metal ion binding
Biological Process: metabolic process
Research Articles on PRUNE
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Pathways associated with anti-PRUNE antibody
Diseases associated with anti-PRUNE antibody
Organs/Tissues associated with anti-PRUNE antibody
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