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anti-PDK2 antibody :: Rabbit pyruvate dehydrogenase kinase, isozyme 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS714040 anti-PDK2 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

pyruvate dehydrogenase kinase, isozyme 2 (PDK2), Polyclonal Antibody

 Also Known As   

Rabbit anti-human pyruvate dehydrogenase kinase, isozyme 2 polyclonal Antibody

 Product Synonym Names    pyruvate dehydrogenase kinase; isozyme 2; PDK2; PDHK2
 Product Gene Name   

anti-PDK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602525
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human PDK2
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-14484 / sc-14486
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-PDK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-PDK2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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NCBI/Uniprot data below describe general gene information for PDK2. It may not necessarily be applicable to this product.
 NCBI GI #    38649337
 NCBI GeneID    5164
 NCBI Accession #    AAH63137.1 [Other Products]
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 UniProt Secondary Accession #    Q6P515; Q9BS05; A8K3A7; B3KNW0 [Other Products]
 UniProt Related Accession #    Q15119 [Other Products]
 Molecular Weight    38,864 Da [Similar Products]
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 NCBI Official Full Name    Pyruvate dehydrogenase kinase, isozyme 2
 NCBI Official Synonym Full Names    pyruvate dehydrogenase kinase, isozyme 2
 NCBI Official Symbol    PDK2 [Similar Products]
 NCBI Official Synonym Symbols   
PDHK2; PDKII
[Similar Products]
 NCBI Protein Information    pyruvate dehydrogenase kinase, isozyme 2; PDH kinase 2; pyruvate dehydrogenase kinase, isoenzyme 2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial; [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
 UniProt Protein Name    [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
 UniProt Synonym Protein Names   
Pyruvate dehydrogenase kinase isoform 2; PDH kinase 2; PDKII
 UniProt Gene Name    PDK2 [Similar Products]
 UniProt Synonym Gene Names    PDHK2; PDH kinase 2; PDKII [Similar Products]
 UniProt Entry Name    PDK2_HUMAN
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 NCBI Summary for PDK2    This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for PDK2    PDHK2: an atypical protein kinase associated with the mitochondrial matrix. The PDHKs play crucial roles in switching metabolic flux from oxidative phosphorylation towards glycolysis. PDHK2 is expressed in all tissues. Contains a HATPase_c catalytic domain, found in several ATP-binding proteins including protein histidine kinases (PHKs), PHDKs, DNA gyrase B, topoisomerases, heat shock proteins, and DNA mismatch repair proteins. PDHK regulates glucose oxidation through inhibitory phosphorylation of the E1 alpha subunit of the mitochondrial pyruvate dehydrogenase complex (PDHC) at any one of 3 inhibitory serine residues. Inhibitory sites 1, 2, and 3 correspond to S293, S300, and S232 in human PDHA1, respectively. Four PDHK isoenzymes have been described, each with different site specificity: all four phosphorylate sites 1 and 2 but at different rates; for site 1 PDHK2 >PDHK4 >PDHK1 >PDHK3; for site 2, PDHK3> PDHK4 > PDHK2 > PDHK1. Only PDHK1 phosphorylates site 3. PDHKs are recruited to the PDHC by binding to a lipoyl group covalently attached to the inner lipoyl domain of the E2 component. PDHA1 deficiency is the most common enzyme defect in patients with primary lactic acidosis. Suppression of PDH by PDHK inhibits the conversion of pyruvate to acetyl-CoA, attenuates mitochondrial respiration, and may contribute to the increased lactate production observed in many tumors. The PDH pathway is repressed in a majority of non-small cell lung carcinomas. Inhibited by AZD7545, dichloroacetate (DCA), and radicicol. Radicicol inhibits kinase activity by binding directly to the ATP-binding pocket of PDHK, similar to HSP90 from the same ATPase/kinase superfamily.

Protein type: EC 2.7.11.2; Protein kinase, atypical; Mitochondrial; Kinase, protein; ATYPICAL group; PDHK family; PDHK subfamily

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm; mitochondrial pyruvate dehydrogenase complex

Molecular Function: protein homodimerization activity; pyruvate dehydrogenase (acetyl-transferring) kinase activity; ATP binding; protein kinase activity

Biological Process: cellular metabolic process; insulin receptor signaling pathway; glucose metabolic process; regulation of pH; regulation of gluconeogenesis; cellular response to nutrient; regulation of acetyl-CoA biosynthetic process from pyruvate; glucose homeostasis; pyruvate metabolic process; protein amino acid phosphorylation
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 Research Articles on PDK2    1. The final compound of this series, 2-[(2,4-dihydroxyphenyl)sulfonyl]isoindoline-4,6-diol, designated PS10, inhibits all four PDK isoforms with IC50 = 0.8 muM for PDK2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PDK2 antibodyPathways associated with anti-PDK2 antibody
 Reference Product  PubMed Publications
 PDK1 antibody  >52 publications with PDK2 and PDK1
 PDPK1 antibody  >17 publications with PDK2 and PDPK1
 AKT1 antibody  >11 publications with PDK2 and AKT1
 SGK1 antibody  >2 publications with PDK2 and SGK1
 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Pyruvate Metabolism Pathway antibodies  Pyruvate Metabolism Pathway Diagram
 Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway antibodies  Pyruvate Metabolism And Citric Acid (TCA) Cycle Pathway Diagram
 Regulation Of Pyruvate Dehydrogenase (PDH) Complex Pathway antibodies  Regulation Of Pyruvate Dehydrogenase (PDH) Complex Pathway Diagram
 The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway antibodies  The Citric Acid (TCA) Cycle And Respiratory Electron Transport Pathway Diagram
Diseases associated with anti-PDK2 antibodyOrgans/Tissues associated with anti-PDK2 antibody
 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >9 publications with PDK2 and Fatty Liver
 Liver Diseases Antibodies  >5 publications with PDK2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >5 publications with PDK2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >5 publications with PDK2 and Nervous System Diseases
 Atrophy Antibodies  >4 publications with PDK2 and Atrophy
 Hyperglycemia Antibodies  >4 publications with PDK2 and Hyperglycemia
 Carcinoma, Hepatocellular Antibodies  >3 publications with PDK2 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >3 publications with PDK2 and Kidney Diseases
 Hypertrophy Antibodies  >2 publications with PDK2 and Hypertrophy
 Inflammation Antibodies  >2 publications with PDK2 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >31 publications with PDK2 and Muscle
 Liver Antibodies  >19 publications with PDK2 and Liver
 Heart Antibodies  >17 publications with PDK2 and Heart
 Blood Antibodies  >15 publications with PDK2 and Blood
 Kidney Antibodies  >9 publications with PDK2 and Kidney
 Pancreas Antibodies  >7 publications with PDK2 and Pancreas
 Brain Antibodies  >6 publications with PDK2 and Brain
 Adipose Tissue Antibodies  >5 publications with PDK2 and Adipose Tissue
 Testis Antibodies  >3 publications with PDK2 and Testis
 Lung Antibodies  >3 publications with PDK2 and Lung
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