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anti-REN antibody :: anti-Human renin IgG fraction, FITC labeled Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135187 anti-REN antibody
Unit / Price
1 mg  /  $395 +1 FREE 8GB USB
10 mg  /  $2,700 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

renin IgG fraction, FITC labeled, Polyclonal Antibody

 Also Known As   

Sheep anti human renin IgG fraction, FITC labeled

 Product Gene Name   

anti-REN antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (204123944..204135465, complement). Location: 1q32
 OMIM    179820
 3D Structure    ModBase 3D Structure for P00797
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Host: Sheep; Source: Sheep serum
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    10.0 mg/ml (lot specific)
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 Immunogen    Recombinant full length wild-type human protein (Glycosylated).
 Target Information    Recognises Renin/Prorenin
 Target Molecular Weight    40000
 Buffer    0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
 Extinction Coefficient    1.36
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 Preparation and Storage    Store at -70 degree C; Protect from light. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-REN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-REN antibody

   FITC labeled polyclonal antibody (host sheep) to human renin. IgG fraction purified by immobilized Protein G.
 Product Categories/Family for anti-REN antibody    Renin/Prorenin; Polyclonal Antibodies to Human Renin
 Applications Tested/Suitable for anti-REN antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for REN. It may not necessarily be applicable to this product.
 NCBI GI #    4506475
 NCBI GeneID    5972
 NCBI Accession #    NP_000528.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000537.3 [Other Products]
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 UniProt Primary Accession #    P00797 [Other Products]
 UniProt Secondary Accession #    Q6FI38; Q6T5C2 [Other Products]
 UniProt Related Accession #    P00797 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    renin preproprotein
 NCBI Official Synonym Full Names    renin
 NCBI Official Symbol    REN [Similar Products]
 NCBI Official Synonym Symbols   
HNFJ2
[Similar Products]
 NCBI Protein Information    renin; angiotensinogenase; renin precursor, renal; angiotensin-forming enzyme
 UniProt Protein Name    Renin
 UniProt Synonym Protein Names   
Angiotensinogenase
 Protein Family    Renin
 UniProt Gene Name    REN [Similar Products]
 UniProt Entry Name    RENI_HUMAN
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 NCBI Summary for REN    Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
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 UniProt Comments for REN    REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; Secreted; Secreted, signal peptide; EC 3.4.23.15

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: extracellular space; cytoplasm; plasma membrane; extracellular region

Molecular Function: peptidase activity; insulin-like growth factor receptor binding; aspartic-type endopeptidase activity; receptor binding

Biological Process: response to cAMP; hormone-mediated signaling; cell maturation; drinking behavior; male gonad development; renin-angiotensin regulation of aldosterone production; response to lipopolysaccharide; angiotensin maturation; proteolysis; cellular protein metabolic process; regulation of blood pressure; beta-amyloid metabolic process; regulation of MAPKKK cascade; mesonephros development; kidney development

Disease: Renal Tubular Dysgenesis; Hyperuricemic Nephropathy, Familial Juvenile, 2
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 Research Articles on REN    1. Aldosterone rise that often occurs during prolonged renin-angiotensin system blockade is rather due to the angiotensin II 'escape' during such blockade.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-REN antibodyPathways associated with anti-REN antibody
 Reference Product  PubMed Publications
 ATP6AP2 antibody  >4 publications with REN and ATP6AP2
 RENBP antibody  >2 publications with REN and RENBP
 PCSK5 antibody  >1 publications with REN and PCSK5
 PCSK1 antibody  >1 publications with REN and PCSK1
 KCTD15 antibody  >1 publications with REN and KCTD15
 Products by Pathway  Pathway Diagram
 ACE Inhibitor Pathway antibodies  ACE Inhibitor Pathway Diagram
 Metabolism Of Angiotensinogen To Angiotensins Pathway antibodies  Metabolism Of Angiotensinogen To Angiotensins Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
 Renin-angiotensin System Pathway antibodies  Renin-angiotensin System Pathway Diagram
Diseases associated with anti-REN antibodyOrgans/Tissues associated with anti-REN antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >711 publications with REN and Heart Diseases
 Hypertension Antibodies  >569 publications with REN and Hypertension
 Drug Toxicity Antibodies  >558 publications with REN and Drug Toxicity
 Necrosis Antibodies  >471 publications with REN and Necrosis
 Kidney Diseases Antibodies  >336 publications with REN and Kidney Diseases
 Myocardial Ischemia Antibodies  >316 publications with REN and Myocardial Ischemia
 Ischemia Antibodies  >301 publications with REN and Ischemia
 Fibrosis Antibodies  >285 publications with REN and Fibrosis
 Myocardial Infarction Antibodies  >198 publications with REN and Myocardial Infarction
 Hemorrhage Antibodies  >175 publications with REN and Hemorrhage
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >749 publications with REN and Kidney
 Lung Antibodies  >737 publications with REN and Lung
 Skin Antibodies  >353 publications with REN and Skin
 Intestine Antibodies  >243 publications with REN and Intestine
 Embryonic Tissue Antibodies  >186 publications with REN and Embryonic Tissue
 Testis Antibodies  >105 publications with REN and Testis
 Pancreas Antibodies  >95 publications with REN and Pancreas
 Ovary Antibodies  >93 publications with REN and Ovary
 Bladder Antibodies  >80 publications with REN and Bladder
 Placenta Antibodies  >63 publications with REN and Placenta
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