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anti-TNFSF11 antibody :: Rabbit sRANK Ligand Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150390
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

sRANK Ligand (TNFSF11), Polyclonal Antibody

★Popular Item★
 Also Known As   

sRANK Ligand Antibody

 Product Synonym Names    sRANK Ligand; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; tumor necrosis factor (ligand) superfamily, member 11
 Product Gene Name   

anti-TNFSF11 antibody

[Similar Products]
 Antibody/Peptide Pairs    sRANK-L peptide (MBS151892) is used for blocking the activity of sRANK Ligand antibody (MBS150390)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 602642
 3D Structure    ModBase 3D Structure for O14788
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    sRANK Ligand Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    sRANK-L antibody was raised against a 14 amino acid synthetic peptide from near the center of human sRANK-L.
 Buffer    sRANK Ligand Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    sRANK Ligand antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-TNFSF11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TNFSF11 antibody

   sRANK Ligand Antibody: The receptor activator of NF-κB ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.
 Applications Tested/Suitable for anti-TNFSF11 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TNFSF11 antibody    sRANK-L antibody can be used for detection of sRANK-L by Western blot at 0.25 - 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.
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 Western Blot (WB) of anti-TNFSF11 antibody    Western blot analysis of sRANK-L in rat liver tissue lysate with sRANK-L antibody at (A) 0.25 and (B) 0.5 μg/mL.
anti-TNFSF11 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-TNFSF11 antibody    Immunohistochemistry of sRANK-L in human liver tissue with sRANK-L antibody at 5 μg/mL.
anti-TNFSF11 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TNFSF11. It may not necessarily be applicable to this product.
 NCBI GI #    4507595
 NCBI GeneID    8600
 NCBI Accession #    NP_003692 [Other Products]
 NCBI GenBank Nucleotide #    NM_003701.3 [Other Products]
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 UniProt Primary Accession #    O14788 [Other Products]
 UniProt Secondary Accession #    O14723; Q96Q17; Q9P2Q3 [Other Products]
 UniProt Related Accession #    O14788 [Other Products]
 Molecular Weight    35 kDa
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 NCBI Official Full Name    tumor necrosis factor ligand superfamily member 11 isoform 1
 NCBI Official Synonym Full Names    tumor necrosis factor (ligand) superfamily, member 11
 NCBI Official Symbol    TNFSF11 [Similar Products]
 NCBI Official Synonym Symbols   
ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2
[Similar Products]
 NCBI Protein Information    tumor necrosis factor ligand superfamily member 11; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand
 UniProt Protein Name    Tumor necrosis factor ligand superfamily member 11
 UniProt Synonym Protein Names   
Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form
 Protein Family    Tumor necrosis factor ligand superfamily
 UniProt Gene Name    TNFSF11 [Similar Products]
 UniProt Synonym Gene Names    OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE [Similar Products]
 UniProt Entry Name    TNF11_HUMAN
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 NCBI Summary for TNFSF11    This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TNFSF11    TNFSF11: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Homotrimer. Up-regulated by T-cell receptor stimulation. Highest in the peripheral lymph nodes, weak in spleen, peripheral blood Leukocytes, bone marrow, heart, placenta, skeletal muscle, stomach and thyroid. Belongs to the tumor necrosis factor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q14

Cellular Component: extracellular space; integral to plasma membrane; cytoplasm; extracellular region

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding

Biological Process: ossification; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of osteoclast differentiation; cytokine and chemokine mediated signaling pathway; mammary gland epithelial cell proliferation; osteoclast differentiation; activation of JNK activity; positive regulation of homotypic cell-cell adhesion; positive regulation of corticotropin-releasing hormone secretion; activation of NF-kappaB transcription factor; calcium ion homeostasis; positive regulation of MAP kinase activity; monocyte chemotaxis; positive regulation of protein kinase B signaling cascade; organ morphogenesis; tumor necrosis factor-mediated signaling pathway; positive regulation of bone resorption; immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of T cell activation; protein homooligomerization; bone resorption

Disease: Osteopetrosis, Autosomal Recessive 2
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 Research Articles on TNFSF11    1. Below-knee arterial calcification severity is clearly correlated with peripheral neuropathy severity and with several usual cardiovascular risk factors, but not with serum RANKL level.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFSF11 antibodyPathways associated with anti-TNFSF11 antibody
 Reference Product  PubMed Publications
 TNFRSF11B antibody  >2336 publications with TNFSF11 and TNFRSF11B
 TNFRSF11A antibody  >1537 publications with TNFSF11 and TNFRSF11A
 NFATC1 antibody  >368 publications with TNFSF11 and NFATC1
 FOS antibody  >219 publications with TNFSF11 and FOS
 PTH antibody  >209 publications with TNFSF11 and PTH
 IL17A antibody  >81 publications with TNFSF11 and IL17A
 STAT3 antibody  >31 publications with TNFSF11 and STAT3
 IL6 antibody  >29 publications with TNFSF11 and IL6
 IL11 antibody  >19 publications with TNFSF11 and IL11
 IL1B antibody  >1 publications with TNFSF11 and IL1B
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL6-mediated Signaling Events Pathway antibodies  IL6-mediated Signaling Events Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Osteoblast Signaling Pathway antibodies  Osteoblast Signaling Pathway Diagram
 Osteoclast Signaling Pathway antibodies  Osteoclast Signaling Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
 Prolactin Signaling Pathway antibodies  Prolactin Signaling Pathway Diagram
Diseases associated with anti-TNFSF11 antibodyOrgans/Tissues associated with anti-TNFSF11 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >1562 publications with TNFSF11 and Necrosis
 Osteoporosis Antibodies  >1146 publications with TNFSF11 and Osteoporosis
 Inflammation Antibodies  >542 publications with TNFSF11 and Inflammation
 Osteolysis Antibodies  >355 publications with TNFSF11 and Osteolysis
 Cardiovascular Diseases Antibodies  >319 publications with TNFSF11 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >242 publications with TNFSF11 and Breast Neoplasms
 Alveolar Bone Loss Antibodies  >156 publications with TNFSF11 and Alveolar Bone Loss
 Pain Antibodies  >132 publications with TNFSF11 and Pain
 Osteopetrosis Antibodies  >124 publications with TNFSF11 and Osteopetrosis
 Neoplasm Metastasis Antibodies  >116 publications with TNFSF11 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >778 publications with TNFSF11 and Connective Tissue
 Brain Antibodies  >346 publications with TNFSF11 and Brain
 Liver Antibodies  >107 publications with TNFSF11 and Liver
 Lymph Node Antibodies  >89 publications with TNFSF11 and Lymph Node
 Pancreas Antibodies  >17 publications with TNFSF11 and Pancreas
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