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anti-SCARB1 antibody :: Rabbit scavenger receptor class B, member 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711158 anti-SCARB1 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

scavenger receptor class B, member 1 (SCARB1), Polyclonal Antibody

 Also Known As   

Rabbit anti-human scavenger receptor class B, member 1 polyclonal Antibody

 Product Synonym Names    scavenger receptor class B; member 1; SCARB1; CD36L1; CLA-1; CLA1; MGC138242; SR-BI; SRB1
 Product Gene Name   

anti-SCARB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 610762
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SCARB1
 Storage Buffer    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-32342 / sc-32350 / sc-67099 / sc-67098
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SCARB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SCARB1 antibody   

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

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NCBI/Uniprot data below describe general gene information for SCARB1. It may not necessarily be applicable to this product.
 NCBI GI #    51593659
 NCBI GeneID    949
 NCBI Accession #    AAH80647.1 [Other Products]
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 UniProt Secondary Accession #    Q14016; Q52LZ5; Q6KFX4; F8W8N0 [Other Products]
 UniProt Related Accession #    Q8WTV0 [Other Products]
 Molecular Weight    56,170 Da [Similar Products]
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 NCBI Official Full Name    Scavenger receptor class B, member 1
 NCBI Official Synonym Full Names    scavenger receptor class B, member 1
 NCBI Official Symbol    SCARB1 [Similar Products]
 NCBI Official Synonym Symbols   
CLA1; SRB1; CLA-1; SR-BI; CD36L1; HDLQTL6
[Similar Products]
 NCBI Protein Information    scavenger receptor class B member 1; CD36 and LIMPII analogous 1; scavenger receptor class B type III; CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
 UniProt Protein Name    Scavenger receptor class B member 1
 UniProt Synonym Protein Names   
CD36 and LIMPII analogous 1; CLA-1; CD36 antigen-like 1; Collagen type I receptor, thrombospondin receptor-like 1; SR-BI; CD_antigen: CD36
 Protein Family    Scavenger receptor
 UniProt Gene Name    SCARB1 [Similar Products]
 UniProt Synonym Gene Names    CD36L1; CLA1; SRB1; CLA-1 [Similar Products]
 UniProt Entry Name    SCRB1_HUMAN
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 NCBI Summary for SCARB1    The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
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 UniProt Comments for SCARB1    SCARB1: Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. Belongs to the CD36 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: cell surface; lysosomal membrane; integral to plasma membrane; microvillus membrane; plasma membrane; caveola

Molecular Function: apolipoprotein A-I binding; protein binding; protein homodimerization activity; lipopolysaccharide binding; phosphatidylserine binding; transporter activity; low-density lipoprotein binding; apolipoprotein binding; lipopolysaccharide receptor activity; high-density lipoprotein binding; phosphatidylinositol binding

Biological Process: receptor-mediated endocytosis; blood vessel endothelial cell migration; viral reproduction; wound healing; positive regulation of nitric-oxide synthase activity; lipoprotein metabolic process; cholesterol efflux; androgen biosynthetic process; regulation of phagocytosis; recognition of apoptotic cell; lipopolysaccharide transport; cholesterol homeostasis; reverse cholesterol transport; endothelial cell proliferation; detection of lipopolysaccharide; lipopolysaccharide-mediated signaling pathway; adhesion to host; phospholipid transport; cell adhesion; cholesterol catabolic process

Disease: High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 6
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 Research Articles on SCARB1    1. In patients with coronary heart disease, HDL levels were negatively correlated with white blood cells count and hematopoietic stem cell (HSPC) frequency in peripheral blood. SR-BI expression was detected on human HSPC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SCARB1 antibodyPathways associated with anti-SCARB1 antibody
 Reference Product  PubMed Publications
 APOE antibody  >112 publications with SCARB1 and APOE
 CD81 antibody  >43 publications with SCARB1 and CD81
 PPARG antibody  >30 publications with SCARB1 and PPARG
 APOA1 antibody  >26 publications with SCARB1 and APOA1
 PDZK1 antibody  >20 publications with SCARB1 and PDZK1
 AKT1 antibody  >5 publications with SCARB1 and AKT1
 TLR4 antibody  >2 publications with SCARB1 and TLR4
 INS antibody  >1 publications with SCARB1 and INS
 Products by Pathway  Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Binding And Uptake Of Ligands By Scavenger Receptors Pathway antibodies  Binding And Uptake Of Ligands By Scavenger Receptors Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Folate Metabolism Pathway antibodies  Folate Metabolism Pathway Diagram
 HDL-mediated Lipid Transport Pathway antibodies  HDL-mediated Lipid Transport Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Lipid Digestion, Mobilization, And Transport Pathway antibodies  Lipid Digestion, Mobilization, And Transport Pathway Diagram
Diseases associated with anti-SCARB1 antibodyOrgans/Tissues associated with anti-SCARB1 antibody
 Disease Name  Pubmed Publications
 Atherosclerosis Antibodies  >322 publications with SCARB1 and Atherosclerosis
 Cardiovascular Diseases Antibodies  >278 publications with SCARB1 and Cardiovascular Diseases
 Inflammation Antibodies  >86 publications with SCARB1 and Inflammation
 Liver Diseases Antibodies  >81 publications with SCARB1 and Liver Diseases
 Disease Models, Animal Antibodies  >68 publications with SCARB1 and Disease Models, Animal
 Dyslipidemias Antibodies  >64 publications with SCARB1 and Dyslipidemias
 Hepatitis C Antibodies  >63 publications with SCARB1 and Hepatitis C
 Hyperlipidemias Antibodies  >51 publications with SCARB1 and Hyperlipidemias
 Necrosis Antibodies  >51 publications with SCARB1 and Necrosis
 Hypercholesterolemia Antibodies  >49 publications with SCARB1 and Hypercholesterolemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >482 publications with SCARB1 and Blood
 Liver Antibodies  >397 publications with SCARB1 and Liver
 Ovary Antibodies  >107 publications with SCARB1 and Ovary
 Muscle Antibodies  >82 publications with SCARB1 and Muscle
 Kidney Antibodies  >71 publications with SCARB1 and Kidney
 Heart Antibodies  >69 publications with SCARB1 and Heart
 Adrenal Gland Antibodies  >65 publications with SCARB1 and Adrenal Gland
 Intestine Antibodies  >54 publications with SCARB1 and Intestine
 Brain Antibodies  >51 publications with SCARB1 and Brain
 Lung Antibodies  >45 publications with SCARB1 and Lung
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