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anti-SERPINA3 antibody :: Rabbit anti-Human serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS713724 anti-SERPINA3 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 (SERPINA3), Polyclonal Antibody

 Also Known As   

Rabbit anti-human serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 polyclonal Antibody

 Product Synonym Names    serpin peptidase inhibitor; clade A (alpha-1 antiproteinase; antitrypsin); member 3; SERPINA3; AACT; ACT; GIG24; GIG25; MGC88254A1-Antichymotrypsin
 Product Gene Name   

anti-SERPINA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    107280
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SERPINA3,AACT
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-22142 / sc-22747
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SERPINA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SERPINA3 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SERPINA3. It may not necessarily be applicable to this product.
 NCBI GI #    127795956
 NCBI GeneID    12
 NCBI Accession #    AAH03559.3 [Other Products]
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 UniProt Secondary Accession #    Q13703; Q2TU87; Q2TU88; Q59GP9; Q6LBY8; Q6LDT7; Q6NSC9; Q8N177; Q96DW8; Q9UC47; B3KVQ7 [Other Products]
 UniProt Related Accession #    P01011 [Other Products]
 Molecular Weight    10,717 Da [Similar Products]
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 NCBI Official Full Name    Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
 NCBI Official Symbol    SERPINA3 [Similar Products]
 NCBI Official Synonym Symbols   
ACT; AACT; GIG24; GIG25
[Similar Products]
 NCBI Protein Information    alpha-1-antichymotrypsin; serpin A3; growth-inhibiting protein 24; growth-inhibiting protein 25; cell growth-inhibiting gene 24/25 protein; serine (or cysteine) proteinase inhibitor, clade A, member 3
 UniProt Protein Name    Alpha-1-antichymotrypsin
 UniProt Synonym Protein Names   
Cell growth-inhibiting gene 24/25 protein; Serpin A3Cleaved into the following chain:Alpha-1-antichymotrypsin His-Pro-less
 Protein Family    Alpha-1-antichymotrypsin
 UniProt Gene Name    SERPINA3 [Similar Products]
 UniProt Synonym Gene Names    AACT; ACT [Similar Products]
 UniProt Entry Name    AACT_HUMAN
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 NCBI Summary for SERPINA3    The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SERPINA3    SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 14q32.1

Cellular Component: extracellular space; extracellular region; intracellular; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding

Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response
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 Research Articles on SERPINA3    1. ACT-17 variation presents a risk factor for Alzheimer's disease in the worldwide population, especially in the Caucasian population.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SERPINA3 antibodyDiseases associated with anti-SERPINA3 antibody
 Products by Pathway  Pathway Diagram
 Selenium Pathway antibodies  Selenium Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with SERPINA3 and Inflammation
 Cardiovascular Diseases Antibodies  >14 publications with SERPINA3 and Cardiovascular Diseases
 Mental Disorders Antibodies  >8 publications with SERPINA3 and Mental Disorders
 Breast Neoplasms Antibodies  >5 publications with SERPINA3 and Breast Neoplasms
 Hypertension Antibodies  >4 publications with SERPINA3 and Hypertension
 Heart Diseases Antibodies  >4 publications with SERPINA3 and Heart Diseases
 Necrosis Antibodies  >4 publications with SERPINA3 and Necrosis
 Liver Diseases Antibodies  >4 publications with SERPINA3 and Liver Diseases
 Heart Failure Antibodies  >1 publications with SERPINA3 and Heart Failure
 Seizures Antibodies  >1 publications with SERPINA3 and Seizures
Organs/Tissues associated with anti-SERPINA3 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >15 publications with SERPINA3 and Blood
 Brain Antibodies  >11 publications with SERPINA3 and Brain
 Liver Antibodies  >7 publications with SERPINA3 and Liver
 Muscle Antibodies  >6 publications with SERPINA3 and Muscle
 Lung Antibodies  >4 publications with SERPINA3 and Lung
 Uterus Antibodies  >4 publications with SERPINA3 and Uterus
 Placenta Antibodies  >3 publications with SERPINA3 and Placenta
 Skin Antibodies  >2 publications with SERPINA3 and Skin
 Eye Antibodies  >2 publications with SERPINA3 and Eye
 Adrenal Gland Antibodies  >2 publications with SERPINA3 and Adrenal Gland
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