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anti-SERPINB6 antibody :: Rabbit serpin peptidase inhibitor, clade B (ovalbumin), member 6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS712162 anti-SERPINB6 antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

serpin peptidase inhibitor, clade B (ovalbumin), member 6 (SERPINB6), Polyclonal Antibody

 Also Known As   

Rabbit anti-human serpin peptidase inhibitor, clade B (ovalbumin), member 6 polyclonal Antibody

 Product Synonym Names    serpin peptidase inhibitor; clade B (ovalbumin); member 6; SERPINB6; CAP; DKFZp686I04222; MGC111370; MSTP057; PI6; PTI; SPI3
 Product Gene Name   

anti-SERPINB6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613453
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human SERPINB6
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-21135 / sc-21143 / sc-292536
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-SERPINB6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SERPINB6 antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for SERPINB6. It may not necessarily be applicable to this product.
 NCBI GI #    119575510
 NCBI GeneID    5269
 NCBI Accession #    EAW55106.1 [Other Products]
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 UniProt Secondary Accession #    Q59F97; Q5TD06; Q7Z2Y7; Q96J44; Q9UDI7; B2RBA8 [Other Products]
 UniProt Related Accession #    P35237 [Other Products]
 Molecular Weight    42,622 Da [Similar Products]
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 NCBI Official Full Name    serpin peptidase inhibitor, clade B (ovalbumin), member 6, isoform CRA_f
 NCBI Official Synonym Full Names    serpin peptidase inhibitor, clade B (ovalbumin), member 6
 NCBI Official Symbol    SERPINB6 [Similar Products]
 NCBI Official Synonym Symbols   
CAP; PI6; PTI; PI-6; SPI3; DFNB91; MSTP057
[Similar Products]
 NCBI Protein Information    serpin B6; cytoplasmic antiproteinase; protease inhibitor 6 (placental thrombin inhibitor); serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6
 UniProt Protein Name    Serpin B6
 UniProt Synonym Protein Names   
Cytoplasmic antiproteinase; CAP; Peptidase inhibitor 6; PI-6; Placental thrombin inhibitor
 Protein Family    Serpin
 UniProt Gene Name    SERPINB6 [Similar Products]
 UniProt Synonym Gene Names    PI6; PTI; CAP; PI-6 [Similar Products]
 UniProt Entry Name    SPB6_HUMAN
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 NCBI Summary for SERPINB6    The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
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 UniProt Comments for SERPINB6    SERPINB6: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood. Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. Defects in SERPINB6 are the cause of deafness autosomal recessive type 91 (DFNB91). It is a form of non- syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. Belongs to the serpin family. Ov-serpin subfamily.

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: extracellular space; protein complex; cytoplasm; cytosol; nucleus

Molecular Function: serine-type endopeptidase inhibitor activity; protease binding

Biological Process: sensory perception of sound

Disease: Deafness, Autosomal Recessive 91
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 Research Articles on SERPINB6    1. A truncating mutation in SERPINB6 is associated with autosomal-recessive nonsyndromic sensorineural hearing loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-SERPINB6 antibodyDiseases associated with anti-SERPINB6 antibody
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with SERPINB6 and Inflammation
 Intestinal Diseases Antibodies  >1 publications with SERPINB6 and Intestinal Diseases
 Recurrence Antibodies  >1 publications with SERPINB6 and Recurrence
Organs/Tissues associated with anti-SERPINB6 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with SERPINB6 and Blood
 Ovary Antibodies  >2 publications with SERPINB6 and Ovary
 Embryonic Tissue Antibodies  >2 publications with SERPINB6 and Embryonic Tissue
 Placenta Antibodies  >2 publications with SERPINB6 and Placenta
 Brain Antibodies  >2 publications with SERPINB6 and Brain
 Nerve Antibodies  >1 publications with SERPINB6 and Nerve
 Skin Antibodies  >1 publications with SERPINB6 and Skin
 Uterus Antibodies  >1 publications with SERPINB6 and Uterus
 Testis Antibodies  >1 publications with SERPINB6 and Testis
 Lung Antibodies  >1 publications with SERPINB6 and Lung
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