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anti-SYN1 antibody :: Rabbit synapsin Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS856779
Testing Data
Unit / Price
0.05 mg  /  $180 +1 FREE 8GB USB
0.1 mg  /  $215 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

synapsin (SYN1), Polyclonal Antibody

 Also Known As   

synapsin (Ab-9) Antibody

 Product Synonym Names    SYN1; Synapsin-1
 Product Gene Name   

anti-SYN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    313440
 3D Structure    ModBase 3D Structure for P17600
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    synapsin (Ab-9) antibody detects endogenous levels of total synapsin protein.
 Purity/Purification    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    50ug/50ul (lot specific)
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 Immunogen    The antiserum was produced against synthesized non-phosphopeptide derived from human synapsin around the phosphorylation site of serine 9 (R-L-SP-D-S).
 All Sites    Human: Ser9; Mouse: Ser9; Rat: Ser9
 Pathway    Neuroscience, Cytoskeletal/Adhesion
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 Preparation and Storage    Store at -20 degree C for 1 year
 Other Notes    Small volumes of anti-SYN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-SYN1 antibody    Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody
 Applications Tested/Suitable for anti-SYN1 antibody   

Western Blot (WB)

 Application Notes for anti-SYN1 antibody    WB: 1:500~1:1000
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 Testing Data of anti-SYN1 antibody    Western blot analysis of extract from mouse brain tissue, using synapsin (Ab-9) antibody and synapsin (phospho-Ser9) antibody (E011278, Line 3 and 4).
anti-SYN1 antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for SYN1. It may not necessarily be applicable to this product.
 NCBI GI #    19924099
 NCBI GeneID    6853
 NCBI Accession #    NP_008881.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_006950.3 [Other Products]
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 UniProt Primary Accession #    P17600 [Other Products]
 UniProt Secondary Accession #    O75825; Q5H9A9; B1AJQ1 [Other Products]
 UniProt Related Accession #    P17600 [Other Products]
 Molecular Weight    70,033 Da [Similar Products]
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 NCBI Official Full Name    synapsin-1 isoform Ia
 NCBI Official Synonym Full Names    synapsin I
 NCBI Official Symbol    SYN1 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    synapsin-1; brain protein 4.1
 UniProt Protein Name    Synapsin-1
 UniProt Synonym Protein Names   
Brain protein 4.1; Synapsin I
 Protein Family    Synapsin
 UniProt Gene Name    SYN1 [Similar Products]
 UniProt Entry Name    SYN1_HUMAN
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 NCBI Summary for SYN1    This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein encoded serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations in this gene may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SYN1    SYN1: neuronal phosphoprotein which associates with the cytoplasmic surface of synaptic vesicles and binds to the cytoskeleton. May function in the regulation of neurotransmitter release and of axonogenesis and synaptogenesis. Mutations may be associated with X-linked disorders with primary neuronal degeneration such as Rett syndrome. Two differentially spiced isoforms have been reported.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xp11.23

Cellular Component: Golgi apparatus; synaptic vesicle; dendrite; cell junction; cytosol

Molecular Function: protein binding; transporter activity; actin binding; calcium-dependent protein binding; protein kinase binding; catalytic activity; ATP binding

Biological Process: synaptic transmission; metabolic process; neurotransmitter secretion; regulation of neurotransmitter secretion

Disease: Epilepsy, X-linked, With Variable Learning Disabilities And Behavior Disorders
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Product References and Citations for anti-SYN1 antibody

   Diviya Sinha, et,al. (2005) Am J Physiol Renal Physiol ; 288: F703 - F713.
Franco Onofri, et,al. (2000) J. Biol. Chem ; 275: 29857.
Dario Bonanomi, et,al. (2005) J. Neurosci; 25: 7299 - 7308.
Hiroshi Tokumitsu, et,al. (2005) J. Biol. Chem ; 280: 35108 - 35118.
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 Research Articles on SYN1    1. The implementation of the AlphaScreen pSYN1 assay and future development of additional primary neuronal HTS assays provides an attractive approach for discovery of novel classes of therapeutic candidates for a variety of CNS disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SYN1 antibodyPathways associated with anti-SYN1 antibody
 Reference Product  PubMed Publications
 BDNF antibody  >2 publications with SYN1 and BDNF
 CALM2 antibody  >1 publications with SYN1 and CALM2
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Dopamine Neurotransmitter Release Cycle Pathway antibodies  Dopamine Neurotransmitter Release Cycle Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Neurotransmitter Release Cycle Pathway antibodies  Neurotransmitter Release Cycle Pathway Diagram
 Serotonin Neurotransmitter Release Cycle Pathway antibodies  Serotonin Neurotransmitter Release Cycle Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
 Transmission Across Chemical Synapses Pathway antibodies  Transmission Across Chemical Synapses Pathway Diagram
Diseases associated with anti-SYN1 antibodyOrgans/Tissues associated with anti-SYN1 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >14 publications with SYN1 and Mental Disorders
 Brain Diseases Antibodies  >12 publications with SYN1 and Brain Diseases
 Central Nervous System Diseases Antibodies  >10 publications with SYN1 and Central Nervous System Diseases
 Cognition Disorders Antibodies  >4 publications with SYN1 and Cognition Disorders
 Neurobehavioral Manifestations Antibodies  >4 publications with SYN1 and Neurobehavioral Manifestations
 Necrosis Antibodies  >4 publications with SYN1 and Necrosis
 Seizures Antibodies  >3 publications with SYN1 and Seizures
 Learning Disorders Antibodies  >3 publications with SYN1 and Learning Disorders
 Chromosome Aberrations Antibodies  >3 publications with SYN1 and Chromosome Aberrations
 Child Behavior Disorders Antibodies  >3 publications with SYN1 and Child Behavior Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >31 publications with SYN1 and Brain
 Nerve Antibodies  >8 publications with SYN1 and Nerve
 Testis Antibodies  >3 publications with SYN1 and Testis
 Placenta Antibodies  >2 publications with SYN1 and Placenta
 Eye Antibodies  >2 publications with SYN1 and Eye
 Connective Tissue Antibodies  >1 publications with SYN1 and Connective Tissue
 Ganglia Antibodies  >1 publications with SYN1 and Ganglia
 Lung Antibodies  >1 publications with SYN1 and Lung
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