NP_001171351.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
synaptotagmin-12
NCBI Official Synonym Full Names
synaptotagmin XII
NCBI Protein Information
synaptotagmin-12; synaptotagmin-XII
UniProt Protein Name
Synaptotagmin-12
UniProt Synonym Protein Names
Synaptotagmin XII; SytXII
UniProt Synonym Gene Names
UniProt Entry Name
SYT12_HUMAN
NCBI Summary for SYT12
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.[provided by RefSeq, Apr 2010]
UniProt Comments for SYT12
SYT12: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Belongs to the synaptotagmin family.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 11q13.2
Cellular Component: synaptic vesicle membrane; integral to membrane; cell junction
Research Articles on SYT12
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Diseases associated with anti-SYT12 antibody
Organs/Tissues associated with anti-SYT12 antibody
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