AAH31265.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Tetraspanin 12
NCBI Official Synonym Full Names
tetraspanin 12
NCBI Protein Information
tetraspanin-12; tspan-12; tetraspan NET-2; transmembrane 4 superfamily member 12
UniProt Protein Name
Tetraspanin-12
UniProt Synonym Protein Names
Tetraspan NET-2; Transmembrane 4 superfamily member 12
UniProt Synonym Gene Names
UniProt Entry Name
TSN12_HUMAN
NCBI Summary for TSPAN12
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. [provided by RefSeq, Jul 2008]
UniProt Comments for TSPAN12
TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q31.31
Cellular Component: membrane; integral to plasma membrane; integral to membrane
Molecular Function: Wnt receptor activity
Biological Process: cell surface receptor linked signal transduction; angiogenesis; regulation of angiogenesis
Disease: Exudative Vitreoretinopathy 5
Research Articles on TSPAN12
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Products associated with anti-TSPAN12 antibody
Diseases associated with anti-TSPAN12 antibody
Organs/Tissues associated with anti-TSPAN12 antibody
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