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anti-THPO antibody :: anti-Mouse thrombopoietin IgG fraction, HRP labeled Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135139 anti-THPO antibody
Unit / Price
1 mg  /  $395 +1 FREE 8GB USB
10 mg  /  $2,700 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

thrombopoietin IgG fraction, HRP labeled (THPO), Polyclonal Antibody

 Also Known As   

Sheep anti mouse thrombopoietin IgG fraction, HRP labeled

 Product Gene Name   

anti-THPO antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000082.6 (20724454..20734511, complement). Location: 16 B1; 16 12.51 cM
 3D Structure    ModBase 3D Structure for P40226
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Host: Sheep; Source: Sheep serum
 Species Reactivity    Mouse
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    2.0 mg/ml (lot specific)
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 Immunogen    Recombinant full length wild-type mouse protein (Glycosylated).
 Target Information    Recognises Thrombopoietin
 Target Molecular Weight    38000
 Buffer    PBS, pH 7.4; 1% BSA, 0.01% Thimerosal
 Extinction Coefficient    1.36
 Preservative    Thimerosal
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 Preparation and Storage    Store at -70 degree C. Shelf Life: 5 years from delivery
 Other Notes    Small volumes of anti-THPO antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-THPO antibody

   Peroxidase labeled polyclonal antibody (host sheep) to mouse thrombopoietin. IgG fraction purified by immobilized Protein G.
 Product Categories/Family for anti-THPO antibody    Thrombopoietin (TPO); Polyclonal Antibodies to Mouse Thrombopoietin
 Applications Tested/Suitable for anti-THPO antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for THPO. It may not necessarily be applicable to this product.
 NCBI GI #    291045237
 NCBI GeneID    21832
 NCBI Accession #    NP_001166976.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001173505.1 [Other Products]
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 UniProt Primary Accession #    P40226 [Other Products]
 UniProt Related Accession #    P40226 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    thrombopoietin
 NCBI Official Synonym Full Names    thrombopoietin
 NCBI Official Symbol    Thpo [Similar Products]
 NCBI Official Synonym Symbols   
Ml; Tpo; Mgdf; Tpo1; Tpo2; Tpo3; Tpo4; Mpllg
[Similar Products]
 NCBI Protein Information    thrombopoietin; C-mpl ligand; megakaryocyte colony-stimulating factor; megakaryocyte growth and development factor; myeloproliferative leukemia virus oncogene ligand
 UniProt Protein Name    Thrombopoietin
 UniProt Synonym Protein Names   
C-mpl ligand; ML; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; MGDF; Myeloproliferative leukemia virus oncogene ligand
 Protein Family    Thrombopoietin
 UniProt Gene Name    Thpo [Similar Products]
 UniProt Synonym Gene Names    ML; MGDF [Similar Products]
 UniProt Entry Name    TPO_MOUSE
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 NCBI Summary for THPO    This gene encodes a humoral growth factor necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. The encoded protein is a ligand for the product of the myeloproliferative leukemia virus oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
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 UniProt Comments for THPO    THPO: Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. Defects in THPO are the cause of thrombocythemia type 1 (THCYT1). A myeloproliferative disorder characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications. Belongs to the EPO/TPO family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Cytokine; Secreted; Cell cycle regulation

Cellular Component: extracellular space; extracellular region

Molecular Function: hormone activity; cytokine activity; receptor binding

Biological Process: cell proliferation; positive regulation of protein kinase B signaling cascade; positive regulation of megakaryocyte differentiation; myeloid cell differentiation; positive regulation of protein amino acid phosphorylation
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 Research Articles on THPO    1. Findings establish that Clock regulates Thpo and Mpl expression in vivo, and demonstrate an important link between the body's circadian timing mechanisms and megakaryopoiesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Sheep anti mouse thrombopoietin IgG fraction, HRP labeled
 Catalog #  Product Name
 MBS135139  Sheep anti mouse thrombopoietin IgG fraction, HRP labeled
Pathways associated with anti-THPO antibodyDiseases associated with anti-THPO antibody
 Products by Pathway  Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Aggregation (Plug Formation) Pathway antibodies  Platelet Aggregation (Plug Formation) Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Disease Name  Pubmed Publications
 Hematologic Diseases Antibodies  >14 publications with THPO and Hematologic Diseases
 Neoplasms Antibodies  >9 publications with THPO and Neoplasms
 Thrombocytosis Antibodies  >8 publications with THPO and Thrombocytosis
 Drug Toxicity Antibodies  >4 publications with THPO and Drug Toxicity
 Anemia Antibodies  >4 publications with THPO and Anemia
 Lung Neoplasms Antibodies  >2 publications with THPO and Lung Neoplasms
 Carcinoma Antibodies  >2 publications with THPO and Carcinoma
 Thrombocythemia, Essential Antibodies  >2 publications with THPO and Thrombocythemia, Essential
 Heart Failure Antibodies  >1 publications with THPO and Heart Failure
 Hypertension Antibodies  >1 publications with THPO and Hypertension
Organs/Tissues associated with anti-THPO antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >38 publications with THPO and Brain
 Kidney Antibodies  >6 publications with THPO and Kidney
 Liver Antibodies  >5 publications with THPO and Liver
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