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anti-TFAP2B antibody :: Rabbit transcription factor AP-2 beta Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS711754 anti-TFAP2B antibody
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.15 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

transcription factor AP-2 beta (TFAP2B), Polyclonal Antibody

 Also Known As   

Rabbit anti-human transcription factor AP-2 beta (activating enhancer binding protein 2 beta) polyclonal Antibody

 Product Synonym Names    transcription factor AP-2 beta (activating enhancer binding protein 2 beta); TFAP2B; AP-2B; AP2-B; MGC21381
 Product Gene Name   

anti-TFAP2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601601
 3D Structure    ModBase 3D Structure for Q92481
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen Affinity Purified
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 Immunogen    Human TFAP2B
 Storage Buffer    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6310 / sc-31932 / sc-31933 / sc-8976
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 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-TFAP2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-TFAP2B antibody   

ELISA (EIA), Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for TFAP2B. It may not necessarily be applicable to this product.
 NCBI GI #    1743256
 NCBI GeneID    7021
 NCBI Accession #    CAA71047.1 [Other Products]
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 UniProt Primary Accession #    Q92481 [Other Products]
 UniProt Secondary Accession #    Q5JYX6; Q9NQ63; Q9NU99; Q9UJI7; Q9Y214; Q9Y3K3 [Other Products]
 UniProt Related Accession #    Q92481 [Other Products]
 Molecular Weight    51,524 Da [Similar Products]
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 NCBI Official Full Name    transcription factor AP-2 beta
 NCBI Official Synonym Full Names    transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
 NCBI Official Symbol    TFAP2B [Similar Products]
 NCBI Official Synonym Symbols   
AP-2B; AP2-B
[Similar Products]
 NCBI Protein Information    transcription factor AP-2-beta; AP2-beta; activating enhancer binding protein 2 beta; activating enhancer-binding protein 2-beta
 UniProt Protein Name    Transcription factor AP-2-beta
 UniProt Synonym Protein Names   
Activating enhancer-binding protein 2-beta
 Protein Family    Transcription factor
 UniProt Gene Name    TFAP2B [Similar Products]
 UniProt Synonym Gene Names    AP2-beta [Similar Products]
 UniProt Entry Name    AP2B_HUMAN
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 NCBI Summary for TFAP2B    This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members differ in their expression patterns and binding affinity for different promoters. This protein functions as both a transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting that this gene functions in the differentiation of neural crest cell derivatives. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TFAP2B    AP-2 beta: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Belongs to the AP-2 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: nucleus

Molecular Function: protein dimerization activity; protein binding; protein homodimerization activity; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; transcription coactivator activity; caspase inhibitor activity; chromatin binding; transcription corepressor activity; transcription factor activity

Biological Process: skin development; transcription from RNA polymerase II promoter; fat cell differentiation; hindlimb morphogenesis; response to lithium ion; positive regulation of transcription, DNA-dependent; regulation of BMP signaling pathway; negative regulation of caspase activity; negative regulation of transcription from RNA polymerase II promoter; glucose homeostasis; calcium ion homeostasis; forelimb morphogenesis; negative regulation of cell proliferation; sympathetic nervous system development; regulation of transcription, DNA-dependent; regulation of cell differentiation; positive regulation of neuron apoptosis; positive regulation of cell proliferation; sodium ion homeostasis; phosphate ion homeostasis; negative regulation of neuron apoptosis; kidney development; potassium ion homeostasis; response to drug; glucose metabolic process; renal water homeostasis; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; regulation of insulin secretion; negative regulation of apoptosis

Disease: Char Syndrome
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 Research Articles on TFAP2B    1. A haploinsufficiency effect of TFAP2B could be involved in familial isolated patent ductus arteriosus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TFAP2B antibodyPathways associated with anti-TFAP2B antibody
 Reference Product  PubMed Publications
 MYC antibody  >29 publications with TFAP2B and MYC
 CITED2 antibody  >14 publications with TFAP2B and CITED2
 TP53 antibody  >4 publications with TFAP2B and TP53
 CITED4 antibody  >2 publications with TFAP2B and CITED4
 SYT4 antibody  >1 publications with TFAP2B and SYT4
 KCTD1 antibody  >1 publications with TFAP2B and KCTD1
 YEATS4 antibody  >1 publications with TFAP2B and YEATS4
 Products by Pathway  Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram
Diseases associated with anti-TFAP2B antibodyOrgans/Tissues associated with anti-TFAP2B antibody
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >88 publications with TFAP2B and Breast Neoplasms
 Congenital Abnormalities Antibodies  >84 publications with TFAP2B and Congenital Abnormalities
 Chromosome Aberrations Antibodies  >59 publications with TFAP2B and Chromosome Aberrations
 Necrosis Antibodies  >54 publications with TFAP2B and Necrosis
 Craniofacial Abnormalities Antibodies  >37 publications with TFAP2B and Craniofacial Abnormalities
 Abnormalities, Multiple Antibodies  >36 publications with TFAP2B and Abnormalities, Multiple
 Neoplasm Metastasis Antibodies  >30 publications with TFAP2B and Neoplasm Metastasis
 Body Weight Antibodies  >28 publications with TFAP2B and Body Weight
 Brain Diseases Antibodies  >23 publications with TFAP2B and Brain Diseases
 Liver Diseases Antibodies  >21 publications with TFAP2B and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >148 publications with TFAP2B and Brain
 Bone Antibodies  >117 publications with TFAP2B and Bone
 Embryonic Tissue Antibodies  >100 publications with TFAP2B and Embryonic Tissue
 Muscle Antibodies  >68 publications with TFAP2B and Muscle
 Kidney Antibodies  >66 publications with TFAP2B and Kidney
 Skin Antibodies  >62 publications with TFAP2B and Skin
 Placenta Antibodies  >59 publications with TFAP2B and Placenta
 Lung Antibodies  >57 publications with TFAP2B and Lung
 Eye Antibodies  >55 publications with TFAP2B and Eye
 Heart Antibodies  >49 publications with TFAP2B and Heart
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